JPS61277618A - 自閉症治療剤 - Google Patents

自閉症治療剤

Info

Publication number
JPS61277618A
JPS61277618A JP60121347A JP12134785A JPS61277618A JP S61277618 A JPS61277618 A JP S61277618A JP 60121347 A JP60121347 A JP 60121347A JP 12134785 A JP12134785 A JP 12134785A JP S61277618 A JPS61277618 A JP S61277618A
Authority
JP
Japan
Prior art keywords
active ingredient
formula
autism
administration
tetrahydrobiopterin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60121347A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0380127B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Hiroshi Naruse
浩 成瀬
Masashi Takesada
武貞 昌志
Osamu Hayaishi
早石 修
Yasuyoshi Watanabe
恭良 渡辺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Priority to JP60121347A priority Critical patent/JPS61277618A/ja
Priority to DE8686107614T priority patent/DE3684190D1/de
Priority to EP86107614A priority patent/EP0209689B1/en
Priority to AT86107614T priority patent/ATE73331T1/de
Priority to US06/870,495 priority patent/US4778794A/en
Publication of JPS61277618A publication Critical patent/JPS61277618A/ja
Priority to US07/210,312 priority patent/US4920122A/en
Publication of JPH0380127B2 publication Critical patent/JPH0380127B2/ja
Granted legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP60121347A 1985-06-04 1985-06-04 自閉症治療剤 Granted JPS61277618A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP60121347A JPS61277618A (ja) 1985-06-04 1985-06-04 自閉症治療剤
DE8686107614T DE3684190D1 (de) 1985-06-04 1986-06-04 Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
EP86107614A EP0209689B1 (en) 1985-06-04 1986-06-04 Use of tetrahydrobiopterins in the preparation of a medicament for the treatment of infantile autism
AT86107614T ATE73331T1 (de) 1985-06-04 1986-06-04 Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
US06/870,495 US4778794A (en) 1985-06-04 1986-06-04 Pharmaceutical composition for the treatment of infantile autism
US07/210,312 US4920122A (en) 1985-06-04 1988-06-23 Pharmaceutical composition and method for the treatment of infantile autism

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60121347A JPS61277618A (ja) 1985-06-04 1985-06-04 自閉症治療剤

Publications (2)

Publication Number Publication Date
JPS61277618A true JPS61277618A (ja) 1986-12-08
JPH0380127B2 JPH0380127B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-12-24

Family

ID=14809022

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60121347A Granted JPS61277618A (ja) 1985-06-04 1985-06-04 自閉症治療剤

Country Status (5)

Country Link
US (2) US4778794A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0209689B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS61277618A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE73331T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3684190D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (7)

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JPH02262517A (ja) * 1982-03-03 1990-10-25 Kanegafuchi Chem Ind Co Ltd プテリン誘導体からなる精神疾患症状の治療剤
WO1996003989A1 (fr) * 1994-08-05 1996-02-15 Suntory Limited Remede contre la degenerescence spino-cerebelleuse
WO1999043325A1 (fr) * 1998-02-27 1999-09-02 Suntory Limited Remedes preventifs ou therapeutiques contre les maladies associees a une anomalie fonctionnelle vasculaire en relation avec la resistance a l'insuline
WO1999043324A1 (fr) * 1998-02-27 1999-09-02 Suntory Limited Agents prophylactiques ou remedes contre les troubles renaux d'origine medicamenteuse
WO2007119367A1 (ja) * 2006-03-20 2007-10-25 Kaneka Corporation ビオプテリンを含む組成物及びその使用方法
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ
US7820667B2 (en) 1996-08-30 2010-10-26 Daiichi Sankyo Company, Limited Methods of treating hypertension

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DE3853711T2 (de) * 1987-11-30 1996-01-11 Vitamin Kenkyusho Kk Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.
US4994467A (en) * 1989-05-31 1991-02-19 Zimmerman Andrew W Treating autism and other developmental disorders in children with NMDA receptor antagonists
WO1998052593A1 (en) 1997-05-19 1998-11-26 Repligen Corporation Method for assisting in differential diagnosis and treatment of autistic syndromes
US6197746B1 (en) * 1998-05-19 2001-03-06 Repligen Corporation Method of using secretin for treating autism
US6365593B2 (en) * 2000-04-12 2002-04-02 Repligen Corporation Methylxanthines in the diagnosis and treatment of autistic disorder
WO2003079886A2 (en) * 2002-03-21 2003-10-02 Hinz Martin C Serotonin and catecholamine system segment optimization techonology
US20060110325A1 (en) * 2003-02-21 2006-05-25 Hinz Martin C Serotonin and catecholamine segment optimization technology
US20090311795A1 (en) * 2002-03-21 2009-12-17 Hinz Martin C Bilateral control of functions traditionally regulated by only serotonin or only dopamine
US20070293571A1 (en) * 2006-06-08 2007-12-20 Hinz Martin C Adminstration of dopa precursors with sources of dopa to effectuate optimal catecholamine neurotransmitter outcomes
DE10260263A1 (de) * 2002-12-20 2004-07-15 Biocrates Life Sciences Gmbh Verwendung von Tetrahydrobiopterinderivaten zur Behandlung und Ernährung von Patienten mit Aminosäurestoffwechselstörungen
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
PT1708690T (pt) * 2003-11-17 2016-09-19 Biomarin Pharm Inc Tratamento de fenilcetonúria com bh4
AU2012200512C1 (en) * 2003-11-17 2020-04-30 Merck & Cie Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
US7585627B2 (en) * 2004-05-21 2009-09-08 Duke University Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis
AU2005259961B2 (en) * 2004-06-25 2012-05-17 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia
EP1845952A2 (en) * 2004-11-17 2007-10-24 Biomarin Pharmaceutical Inc. Stable tablet formulation of tetrahydrobiopterin
EP1819340A2 (en) * 2004-12-08 2007-08-22 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
US20070034214A1 (en) * 2005-08-12 2007-02-15 Dochniak Michael J Method to affect the development of autism spectrum disorders
EP1965803A1 (en) * 2005-12-05 2008-09-10 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of disease
US20100009997A1 (en) * 2007-01-12 2010-01-14 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiarty disorder with a bh4 derivative prodrug
PL2139485T3 (pl) 2007-04-11 2013-03-29 Biomarin Pharm Inc Metoda podawania tetrahydrobiopteryny, powiązane kompozycje i sposoby pomiaru
WO2009088530A1 (en) 2008-01-03 2009-07-16 Biomarin Pharmaceutical Inc. Pterin analog for treating bh4 responsive condition
US20110104074A1 (en) * 2008-06-18 2011-05-05 University Of Louisville Research Foundation, Inc. Methods for targeted cancer treatment and detection
JP2011530540A (ja) * 2008-08-12 2011-12-22 オルファ スイス ゲーエムベーハー テトラヒドロビオプテリンを含有する医薬剤形
JP5066756B2 (ja) * 2010-04-22 2012-11-07 学校法人日本大学 脳機能障害予防・改善用の薬剤及び飲食物
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CA2828685C (en) * 2011-03-01 2018-05-29 Rubicon Research Private Limited Stable compositions of tetrahydrobiopterin
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
JP2015522531A (ja) 2012-05-07 2015-08-06 セリックスビオ プライヴェート リミテッド 神経筋疾患及び神経変性疾患の治療のための組成物及び方法
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* Cited by examiner, † Cited by third party
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GB8318833D0 (en) * 1983-07-12 1983-08-10 Wellcome Found Chemical compounds
AU572792B2 (en) * 1982-09-20 1988-05-19 Wellcome Foundation Limited, The 2-amino, 4-oxo-pteridine derivatives
JPS5976086A (ja) * 1982-09-20 1984-04-28 ザ ウエルカム フアウンデ−シヨン リミテツド プテリジン化合物

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02262517A (ja) * 1982-03-03 1990-10-25 Kanegafuchi Chem Ind Co Ltd プテリン誘導体からなる精神疾患症状の治療剤
WO1996003989A1 (fr) * 1994-08-05 1996-02-15 Suntory Limited Remede contre la degenerescence spino-cerebelleuse
US7820667B2 (en) 1996-08-30 2010-10-26 Daiichi Sankyo Company, Limited Methods of treating hypertension
WO1999043325A1 (fr) * 1998-02-27 1999-09-02 Suntory Limited Remedes preventifs ou therapeutiques contre les maladies associees a une anomalie fonctionnelle vasculaire en relation avec la resistance a l'insuline
WO1999043324A1 (fr) * 1998-02-27 1999-09-02 Suntory Limited Agents prophylactiques ou remedes contre les troubles renaux d'origine medicamenteuse
US6288067B1 (en) 1998-02-27 2001-09-11 Suntory Limited Prophylactic or therapeutic agents for drug-induced renal injury
US6410535B1 (en) 1998-02-27 2002-06-25 Suntory Limited Prophylactic or therapeutic agents for diseases having vascular dysfunction associated with insulin resistance
WO2007119367A1 (ja) * 2006-03-20 2007-10-25 Kaneka Corporation ビオプテリンを含む組成物及びその使用方法
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ

Also Published As

Publication number Publication date
DE3684190D1 (de) 1992-04-16
ATE73331T1 (de) 1992-03-15
EP0209689A2 (en) 1987-01-28
US4778794A (en) 1988-10-18
EP0209689B1 (en) 1992-03-11
JPH0380127B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-12-24
EP0209689A3 (en) 1989-12-20
US4920122A (en) 1990-04-24

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