JPS61267595A - 新規白金錯体 - Google Patents
新規白金錯体Info
- Publication number
- JPS61267595A JPS61267595A JP61011461A JP1146186A JPS61267595A JP S61267595 A JPS61267595 A JP S61267595A JP 61011461 A JP61011461 A JP 61011461A JP 1146186 A JP1146186 A JP 1146186A JP S61267595 A JPS61267595 A JP S61267595A
- Authority
- JP
- Japan
- Prior art keywords
- platinum
- aminomethylaziridine
- platinum complex
- reacted
- novel platinum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 229910052697 platinum Inorganic materials 0.000 title claims abstract description 6
- 239000000126 substance Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- AEXCVBXGIHNPIK-UHFFFAOYSA-N aziridin-2-ylmethanamine Chemical compound NCC1CN1 AEXCVBXGIHNPIK-UHFFFAOYSA-N 0.000 abstract description 7
- 150000001875 compounds Chemical class 0.000 abstract description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 4
- 239000002246 antineoplastic agent Substances 0.000 abstract description 3
- 231100000053 low toxicity Toxicity 0.000 abstract description 3
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 abstract description 3
- QPINXQCQOKBINJ-UHFFFAOYSA-K potassium;platinum(2+);trichloride Chemical compound [Cl-].[Cl-].[Cl-].[K+].[Pt+2] QPINXQCQOKBINJ-UHFFFAOYSA-K 0.000 abstract description 2
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 description 7
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 201000009030 Carcinoma Diseases 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 229960004316 cisplatin Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 150000003057 platinum Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- -1 (2- Aminomethylaziridine) platinum (IV) Chemical compound 0.000 description 1
- 206010029155 Nephropathy toxic Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 125000003963 dichloro group Chemical group Cl* 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000007694 nephrotoxicity Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60-8383 | 1984-12-22 | ||
| JP838385 | 1985-01-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61267595A true JPS61267595A (ja) | 1986-11-27 |
| JPH0569113B2 JPH0569113B2 (enrdf_load_stackoverflow) | 1993-09-30 |
Family
ID=11691693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61011461A Granted JPS61267595A (ja) | 1985-01-22 | 1986-01-22 | 新規白金錯体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61267595A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6310725A (ja) * | 1986-03-11 | 1988-01-18 | Chugai Pharmaceut Co Ltd | 新規白金錯体化合物を有効成分として含有する制癌剤 |
| JPS6310724A (ja) * | 1986-03-11 | 1988-01-18 | Chugai Pharmaceut Co Ltd | 新規白金錯体を有効成分として含有する制癌剤 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH093711A (ja) * | 1995-06-16 | 1997-01-07 | Nagai Emiko | 長袖部肩部襟部開閉衣類 |
-
1986
- 1986-01-22 JP JP61011461A patent/JPS61267595A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6310725A (ja) * | 1986-03-11 | 1988-01-18 | Chugai Pharmaceut Co Ltd | 新規白金錯体化合物を有効成分として含有する制癌剤 |
| JPS6310724A (ja) * | 1986-03-11 | 1988-01-18 | Chugai Pharmaceut Co Ltd | 新規白金錯体を有効成分として含有する制癌剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0569113B2 (enrdf_load_stackoverflow) | 1993-09-30 |
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