JPS61149082A - 発酵法によるｌ―トリプトファンの製造法 - Google Patents
発酵法によるｌ―トリプトファンの製造法Info
- Publication number
- JPS61149082A JPS61149082A JP59277235A JP27723584A JPS61149082A JP S61149082 A JPS61149082 A JP S61149082A JP 59277235 A JP59277235 A JP 59277235A JP 27723584 A JP27723584 A JP 27723584A JP S61149082 A JPS61149082 A JP S61149082A
- Authority
- JP
- Japan
- Prior art keywords
- tryptophan
- gene
- coryneform bacteria
- recombinant dna
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004511 Recombinant DNA Proteins 0.000 title claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract description 23
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- 239000013600 plasmid vector Substances 0.000 claims abstract description 8
- 108010075344 Tryptophan synthase Proteins 0.000 claims abstract description 4
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- -1 phosphoribosyl Chemical group 0.000 claims description 4
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 claims description 2
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- 229930195712 glutamate Natural products 0.000 description 7
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
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- 238000000926 separation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 101150016309 trpC gene Proteins 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59277235A JPS61149082A (ja) | 1984-12-25 | 1984-12-25 | 発酵法によるｌ―トリプトファンの製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59277235A JPS61149082A (ja) | 1984-12-25 | 1984-12-25 | 発酵法によるｌ―トリプトファンの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61149082A true JPS61149082A (ja) | 1986-07-07 |
| JPH055479B2 JPH055479B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-01-22 |
Family
ID=17580698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59277235A Granted JPS61149082A (ja) | 1984-12-25 | 1984-12-25 | 発酵法によるｌ―トリプトファンの製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61149082A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01265892A (ja) * | 1988-04-18 | 1989-10-23 | Kyowa Hakko Kogyo Co Ltd | Ｌ−トリプトファンの製造法 |
| JPH0242988A (ja) * | 1988-08-03 | 1990-02-13 | Ajinomoto Co Inc | 組換えｄｎａ、該組換えｄｎａを有する微生物及び該微生物を用いるｌ−アミノ酸の製造法 |
| EP0401735A1 (en) | 1989-06-06 | 1990-12-12 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing -L-tryptophan |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59156292A (ja) * | 1983-02-17 | 1984-09-05 | Kyowa Hakko Kogyo Co Ltd | トリプトフアンの製造法 |
| JPS59196098A (ja) * | 1983-04-23 | 1984-11-07 | Ajinomoto Co Inc | 発酵法によるｌ−トリプトフアンの製造法 |
-
1984
- 1984-12-25 JP JP59277235A patent/JPS61149082A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59156292A (ja) * | 1983-02-17 | 1984-09-05 | Kyowa Hakko Kogyo Co Ltd | トリプトフアンの製造法 |
| JPS59196098A (ja) * | 1983-04-23 | 1984-11-07 | Ajinomoto Co Inc | 発酵法によるｌ−トリプトフアンの製造法 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01265892A (ja) * | 1988-04-18 | 1989-10-23 | Kyowa Hakko Kogyo Co Ltd | Ｌ−トリプトファンの製造法 |
| US5563052A (en) * | 1988-04-18 | 1996-10-08 | Kyowa Hakko Kogyo Co., Ltd | Process for producing L-tryptophan |
| JPH0242988A (ja) * | 1988-08-03 | 1990-02-13 | Ajinomoto Co Inc | 組換えｄｎａ、該組換えｄｎａを有する微生物及び該微生物を用いるｌ−アミノ酸の製造法 |
| EP0401735A1 (en) | 1989-06-06 | 1990-12-12 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing -L-tryptophan |
| US5407824A (en) * | 1989-06-06 | 1995-04-18 | Kyowa Hakko Kogyo Co., Ltd. | Recombinant coryneform bacterium for producing L-tryptophan |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH055479B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |