JPS6113957A - 眼科領域における手術・治療用注入可能粘弾性ゲル - Google Patents
眼科領域における手術・治療用注入可能粘弾性ゲルInfo
- Publication number
- JPS6113957A JPS6113957A JP60139243A JP13924385A JPS6113957A JP S6113957 A JPS6113957 A JP S6113957A JP 60139243 A JP60139243 A JP 60139243A JP 13924385 A JP13924385 A JP 13924385A JP S6113957 A JPS6113957 A JP S6113957A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- chloride
- gel
- polymer
- million
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002401 polyacrylamide Polymers 0.000 claims abstract description 10
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- 238000001356 surgical procedure Methods 0.000 claims description 15
- 229920000642 polymer Polymers 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 9
- 239000001110 calcium chloride Substances 0.000 claims description 9
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 9
- 239000001103 potassium chloride Substances 0.000 claims description 9
- 235000011164 potassium chloride Nutrition 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229940050906 magnesium chloride hexahydrate Drugs 0.000 claims description 7
- DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 claims description 7
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 6
- 239000001632 sodium acetate Substances 0.000 claims description 6
- 235000017281 sodium acetate Nutrition 0.000 claims description 6
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 6
- 229960000999 sodium citrate dihydrate Drugs 0.000 claims description 6
- 239000012266 salt solution Substances 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 229920002959 polymer blend Polymers 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 2
- 239000003349 gelling agent Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 10
- 238000009472 formulation Methods 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 210000002159 anterior chamber Anatomy 0.000 description 2
- 210000000399 corneal endothelial cell Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000008154 viscoelastic solution Substances 0.000 description 2
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 206010038848 Retinal detachment Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000871 endothelium corneal Anatomy 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960002337 magnesium chloride Drugs 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000004264 retinal detachment Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000003190 viscoelastic substance Substances 0.000 description 1
- 229940006076 viscoelastic substance Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Prostheses (AREA)
- Biological Depolymerization Polymers (AREA)
- Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US625249 | 1984-06-27 | ||
| US06/625,249 US4540568A (en) | 1982-10-14 | 1984-06-27 | Injectionable viscoelastic ophthalmic gel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6113957A true JPS6113957A (ja) | 1986-01-22 |
| JPH0455070B2 JPH0455070B2 (cg-RX-API-DMAC7.html) | 1992-09-02 |
Family
ID=24505208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60139243A Granted JPS6113957A (ja) | 1984-06-27 | 1985-06-27 | 眼科領域における手術・治療用注入可能粘弾性ゲル |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4540568A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0166061B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS6113957A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE60998T1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU571038B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1238278A (cg-RX-API-DMAC7.html) |
| DE (1) | DE3484203D1 (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05502716A (ja) * | 1989-12-08 | 1993-05-13 | アクア−ウォール ダンマーク アクティーゼルスカブ | 空気加湿装置 |
| JPH07500593A (ja) * | 1991-10-16 | 1995-01-19 | リチャードソン、ビックス、インコーポレーテッド | 非イオン性ポリアクリルアミド誘導体を含有した低ｐＨ水性化粧品ゲル |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713446A (en) * | 1985-09-06 | 1987-12-15 | Minnesota Mining And Manufacturing Company | Viscoelastic collagen solution for ophthalmic use and method of preparation |
| US4851513A (en) * | 1985-09-06 | 1989-07-25 | Minnesota Mining And Manufacturing Company | Viscoelastic collagen solution for opthalmic use and method of preparation |
| US4883864A (en) * | 1985-09-06 | 1989-11-28 | Minnesota Mining And Manufacturing Company | Modified collagen compound and method of preparation |
| IL80298A (en) * | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
| WO1988009665A1 (en) * | 1987-06-01 | 1988-12-15 | Allergan, Inc. | Preservative free ophthalmic ointments |
| US4828828A (en) * | 1987-07-28 | 1989-05-09 | Trager Seymour F | Method of treating degenerative joint disease by injection of meth(acrylamide) (co)-polymers |
| US4965253A (en) * | 1987-10-14 | 1990-10-23 | University Of Florida | Viscoelastic material for ophthalmic surgery |
| US4909784A (en) * | 1988-03-25 | 1990-03-20 | Seymour Dubroff | Method for preventing clouding of posterior capsule after extracapsular cataract eye surgery |
| US5271943A (en) * | 1989-10-27 | 1993-12-21 | Scott Health Care | Wound gel compositions containing sodium chloride and method of using them |
| US5103840A (en) * | 1990-05-07 | 1992-04-14 | Kavoussi Harold P | Viscoelastic collagen gel for ophthalmic surgery |
| US5323775A (en) * | 1991-09-13 | 1994-06-28 | Allergan, Inc. | Diagnostic method for determining precorneal retention time of ophthalmic formulations |
| CA2120927A1 (en) * | 1991-10-16 | 1993-04-29 | George E. Deckner | Enhanced skin penetration system for improved topical delivery of drugs |
| EG20380A (en) | 1991-10-16 | 1999-02-28 | Richardson Vicks Inc | Enhanced skin penetration system for improved topical delivery of drugs |
| CA2141192C (en) * | 1992-07-28 | 1999-02-02 | Roberta C. Bloom | Pharmaceutical composition for topical use containing a crosslinked cationic polymer and an alkoxylated ether |
| US5989536A (en) * | 1993-07-03 | 1999-11-23 | The Procter & Gamble Company | Personal cleansing compositions containing alkoxylated ether and cationic ammonium salt for deposition of active agent upon the skin |
| UA10911C2 (uk) * | 1994-08-10 | 1996-12-25 | Мале Впроваджувальне Підприємство "Іhтерфалл" | Біосумісhий гідрогель |
| US6955821B2 (en) * | 2000-04-28 | 2005-10-18 | Adams Laboratories, Inc. | Sustained release formulations of guaifenesin and additional drug ingredients |
| MY130475A (en) * | 2000-08-25 | 2007-06-29 | Contura As | Polyacrylamide hydrogel and its use as an endoprosthesis |
| DK1418188T3 (da) * | 2000-08-25 | 2010-02-08 | Contura As | Polyacrylamid-hydrogel og dets anvendelse som endoprotese |
| US7186419B2 (en) | 2000-08-25 | 2007-03-06 | Contura Sa | Polyacrylamide hydrogel for arthritis |
| WO2003000231A1 (en) * | 2001-06-22 | 2003-01-03 | Alcon, Inc. | Hydration compositions for corneal pre-surgery treatment |
| RU2192860C1 (ru) * | 2001-07-04 | 2002-11-20 | Общество с ограниченной ответственностью "Научно-экспериментальное производство Микрохирургия глаза" | Мазь для лечения блефаритов и блефароконъюнктивитов |
| CN104523575B (zh) * | 2014-12-24 | 2017-09-26 | 昆明振华制药厂有限公司 | 一种盐酸羟苄唑眼用凝胶剂及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59101421A (ja) * | 1982-11-29 | 1984-06-12 | Kaken Pharmaceut Co Ltd | 眼科用潅流液 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3978201A (en) * | 1972-11-27 | 1976-08-31 | Gennady Lvovich Khromov | Base for ophthalmological medicinal preparation on opthalmological medicinal film |
| SE375007B (cg-RX-API-DMAC7.html) * | 1972-11-30 | 1975-04-07 | Pharmacia Ab | |
| US3920810A (en) * | 1974-04-23 | 1975-11-18 | Burton Parsons And Company Inc | Polyacrylamide containing ophthalmic solutions |
| CH618092A5 (en) * | 1974-04-23 | 1980-07-15 | Vnii Khirurgicheskoi Apparatur | Process for the production of a biosoluble basic composition for ophthalmological films |
| US4003991A (en) * | 1974-08-27 | 1977-01-18 | National Patent Development Corporation | Ophthalmic formulation |
| US4271144A (en) * | 1979-06-06 | 1981-06-02 | Holles Laboratories, Inc. | Dextran composition for controlling corneal hydration |
| DE3050012A1 (de) * | 1979-11-06 | 1982-05-06 | I Bilko | Polyacrylamide gel for medical and biological application and method of its preparation |
| EP0014238A3 (de) * | 1979-11-23 | 1980-10-29 | Albert E. Posthuma | Schleimbildendes synthetisches Schmier- und Gleitmittel, insbesondere für den Vaginalbereich, und dessen Verwendung im Bereich der diagnostischen, chirurgischen und behandelnden Medizin |
| ATE42196T1 (de) * | 1982-12-13 | 1989-05-15 | American Cyanamid Co | Athelminthische gele und verfahren zu deren herstellung bei raumtemperatur. |
-
1984
- 1984-06-27 US US06/625,249 patent/US4540568A/en not_active Ceased
- 1984-11-14 CA CA000467845A patent/CA1238278A/en not_active Expired
- 1984-11-27 EP EP84402417A patent/EP0166061B1/en not_active Expired - Lifetime
- 1984-11-27 AT AT84402417T patent/ATE60998T1/de active
- 1984-11-27 DE DE8484402417T patent/DE3484203D1/de not_active Expired - Lifetime
- 1984-12-13 AU AU36660/84A patent/AU571038B2/en not_active Ceased
-
1985
- 1985-06-27 JP JP60139243A patent/JPS6113957A/ja active Granted
-
1988
- 1988-01-07 AU AU10009/88A patent/AU601254B2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59101421A (ja) * | 1982-11-29 | 1984-06-12 | Kaken Pharmaceut Co Ltd | 眼科用潅流液 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05502716A (ja) * | 1989-12-08 | 1993-05-13 | アクア−ウォール ダンマーク アクティーゼルスカブ | 空気加湿装置 |
| JPH07500593A (ja) * | 1991-10-16 | 1995-01-19 | リチャードソン、ビックス、インコーポレーテッド | 非イオン性ポリアクリルアミド誘導体を含有した低ｐＨ水性化粧品ゲル |
Also Published As
| Publication number | Publication date |
|---|---|
| US4540568A (en) | 1985-09-10 |
| EP0166061B1 (en) | 1991-02-27 |
| CA1238278A (en) | 1988-06-21 |
| AU571038B2 (en) | 1988-03-31 |
| EP0166061A3 (en) | 1987-01-07 |
| AU3666084A (en) | 1986-01-02 |
| JPH0455070B2 (cg-RX-API-DMAC7.html) | 1992-09-02 |
| AU1000988A (en) | 1988-04-28 |
| AU601254B2 (en) | 1990-09-06 |
| ATE60998T1 (de) | 1991-03-15 |
| EP0166061A2 (en) | 1986-01-02 |
| DE3484203D1 (de) | 1991-04-04 |
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