JPS61129129A - 抗腫瘍剤 - Google Patents
抗腫瘍剤Info
- Publication number
- JPS61129129A JPS61129129A JP25128484A JP25128484A JPS61129129A JP S61129129 A JPS61129129 A JP S61129129A JP 25128484 A JP25128484 A JP 25128484A JP 25128484 A JP25128484 A JP 25128484A JP S61129129 A JPS61129129 A JP S61129129A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- antitumor agent
- tumor
- formula
- agent containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002246 antineoplastic agent Substances 0.000 title claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 abstract description 9
- 239000000243 solution Substances 0.000 abstract description 6
- 241001465754 Metazoa Species 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 239000008187 granular material Substances 0.000 abstract description 3
- 238000002347 injection Methods 0.000 abstract description 3
- 239000007924 injection Substances 0.000 abstract description 3
- 239000000843 powder Substances 0.000 abstract description 3
- 239000003826 tablet Substances 0.000 abstract description 3
- 239000003708 ampul Substances 0.000 abstract description 2
- 239000002775 capsule Substances 0.000 abstract description 2
- 239000002674 ointment Substances 0.000 abstract description 2
- 238000007911 parenteral administration Methods 0.000 abstract description 2
- 210000004881 tumor cell Anatomy 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000004503 fine granule Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25128484A JPS61129129A (ja) | 1984-11-28 | 1984-11-28 | 抗腫瘍剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25128484A JPS61129129A (ja) | 1984-11-28 | 1984-11-28 | 抗腫瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61129129A true JPS61129129A (ja) | 1986-06-17 |
| JPH0430924B2 JPH0430924B2 (en, 2012) | 1992-05-25 |
Family
ID=17220510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25128484A Granted JPS61129129A (ja) | 1984-11-28 | 1984-11-28 | 抗腫瘍剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61129129A (en, 2012) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0784055A4 (en) * | 1994-09-26 | 1998-01-07 | Daiichi Seiyaku Co | PYRIMIDINYLPYRAZOLE DERIVATIVE |
| EP1022270A4 (en) * | 1997-01-27 | 2002-01-30 | Daiichi Seiyaku Co | PIRAZOLE DERIVATIVES |
| US6552018B1 (en) | 1997-01-27 | 2003-04-22 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| FR2850379A1 (fr) * | 2003-01-28 | 2004-07-30 | Aventis Pharma Sa | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
| WO2004078732A1 (fr) * | 2003-01-28 | 2004-09-16 | Aventis Pharma S.A. | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
| JP2012522847A (ja) * | 2009-04-06 | 2012-09-27 | アジオス ファーマシューティカルズ， インコーポレイテッド | ピルビン酸キナーゼｍ２調節剤、治療組成物および関連する使用方法 |
| US8889667B2 (en) | 2010-12-29 | 2014-11-18 | Agios Pharmaceuticals, Inc | Therapeutic compounds and compositions |
| US9115086B2 (en) | 2009-06-29 | 2015-08-25 | Agios Pharmaceuticals, Inc. | Therapeutic compositions and related methods of use |
| US9181231B2 (en) | 2011-05-03 | 2015-11-10 | Agios Pharmaceuticals, Inc | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| US9221792B2 (en) | 2010-12-17 | 2015-12-29 | Agios Pharmaceuticals, Inc | N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators |
| US9328077B2 (en) | 2010-12-21 | 2016-05-03 | Agios Pharmaceuticals, Inc | Bicyclic PKM2 activators |
| US9365545B2 (en) | 2013-03-15 | 2016-06-14 | Agios Pharmaceuticals, Inc | Therapeutic compounds and compositions |
| US9980961B2 (en) | 2011-05-03 | 2018-05-29 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in therapy |
| US10029987B2 (en) | 2009-06-29 | 2018-07-24 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| US11234976B2 (en) | 2015-06-11 | 2022-02-01 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
-
1984
- 1984-11-28 JP JP25128484A patent/JPS61129129A/ja active Granted
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0784055A4 (en) * | 1994-09-26 | 1998-01-07 | Daiichi Seiyaku Co | PYRIMIDINYLPYRAZOLE DERIVATIVE |
| US5852019A (en) * | 1994-09-26 | 1998-12-22 | Daiichi Pharmaceutical Co., Ltd. | Pyrimidinylpyrazole derivatives |
| EP1022270A4 (en) * | 1997-01-27 | 2002-01-30 | Daiichi Seiyaku Co | PIRAZOLE DERIVATIVES |
| US6552018B1 (en) | 1997-01-27 | 2003-04-22 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| FR2850379A1 (fr) * | 2003-01-28 | 2004-07-30 | Aventis Pharma Sa | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
| WO2004078732A1 (fr) * | 2003-01-28 | 2004-09-16 | Aventis Pharma S.A. | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
| JP2012522847A (ja) * | 2009-04-06 | 2012-09-27 | アジオス ファーマシューティカルズ， インコーポレイテッド | ピルビン酸キナーゼｍ２調節剤、治療組成物および関連する使用方法 |
| US9938259B2 (en) | 2009-04-06 | 2018-04-10 | Agios Pharmaceuticals, Inc. | Therapeutic compositions and related methods of use |
| US9657004B2 (en) | 2009-04-06 | 2017-05-23 | Agios Pharmaceuticals, Inc | Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use |
| US11866411B2 (en) | 2009-06-29 | 2024-01-09 | Agios Pharmaceutical, Inc. | Therapeutic compounds and compositions |
| US9115086B2 (en) | 2009-06-29 | 2015-08-25 | Agios Pharmaceuticals, Inc. | Therapeutic compositions and related methods of use |
| USRE49582E1 (en) | 2009-06-29 | 2023-07-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| US10988448B2 (en) | 2009-06-29 | 2021-04-27 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| US10029987B2 (en) | 2009-06-29 | 2018-07-24 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| US9221792B2 (en) | 2010-12-17 | 2015-12-29 | Agios Pharmaceuticals, Inc | N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators |
| US9328077B2 (en) | 2010-12-21 | 2016-05-03 | Agios Pharmaceuticals, Inc | Bicyclic PKM2 activators |
| US10087169B2 (en) | 2010-12-21 | 2018-10-02 | Agios Pharmaceuticals, Inc. | Bicyclic PKM2 activators |
| US9199968B2 (en) | 2010-12-29 | 2015-12-01 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| US8889667B2 (en) | 2010-12-29 | 2014-11-18 | Agios Pharmaceuticals, Inc | Therapeutic compounds and compositions |
| US9980961B2 (en) | 2011-05-03 | 2018-05-29 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in therapy |
| US10632114B2 (en) | 2011-05-03 | 2020-04-28 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in therapy |
| US9181231B2 (en) | 2011-05-03 | 2015-11-10 | Agios Pharmaceuticals, Inc | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| US11793806B2 (en) | 2011-05-03 | 2023-10-24 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in therapy |
| US12377093B2 (en) | 2011-05-03 | 2025-08-05 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in therapy |
| US9365545B2 (en) | 2013-03-15 | 2016-06-14 | Agios Pharmaceuticals, Inc | Therapeutic compounds and compositions |
| US11234976B2 (en) | 2015-06-11 | 2022-02-01 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0430924B2 (en, 2012) | 1992-05-25 |
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