JPS61109716A - う蝕菌生育阻害剤 - Google Patents
う蝕菌生育阻害剤Info
- Publication number
- JPS61109716A JPS61109716A JP22897384A JP22897384A JPS61109716A JP S61109716 A JPS61109716 A JP S61109716A JP 22897384 A JP22897384 A JP 22897384A JP 22897384 A JP22897384 A JP 22897384A JP S61109716 A JPS61109716 A JP S61109716A
- Authority
- JP
- Japan
- Prior art keywords
- maltol
- bacteria
- agent
- dental caries
- inhibiting growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002925 dental caries Diseases 0.000 title claims abstract description 14
- 241000894006 Bacteria Species 0.000 title abstract description 15
- 230000002401 inhibitory effect Effects 0.000 title abstract description 9
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims abstract description 34
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940043353 maltol Drugs 0.000 claims abstract description 17
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940093503 ethyl maltol Drugs 0.000 claims abstract description 16
- 239000004480 active ingredient Substances 0.000 claims abstract description 3
- 239000003966 growth inhibitor Substances 0.000 claims description 8
- 241000194019 Streptococcus mutans Species 0.000 abstract description 14
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 9
- 230000015572 biosynthetic process Effects 0.000 abstract description 9
- 239000000203 mixture Substances 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 8
- 239000000796 flavoring agent Substances 0.000 abstract description 5
- 235000019634 flavors Nutrition 0.000 abstract description 4
- 210000000214 mouth Anatomy 0.000 abstract description 4
- 230000001580 bacterial effect Effects 0.000 abstract description 3
- 235000015218 chewing gum Nutrition 0.000 abstract description 3
- 229940112822 chewing gum Drugs 0.000 abstract description 3
- 235000009508 confectionery Nutrition 0.000 abstract description 3
- 239000002324 mouth wash Substances 0.000 abstract description 3
- 235000019219 chocolate Nutrition 0.000 abstract description 2
- 235000019264 food flavour enhancer Nutrition 0.000 abstract description 2
- 229940051866 mouthwash Drugs 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 235000012970 cakes Nutrition 0.000 abstract 1
- 239000000551 dentifrice Substances 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 208000002064 Dental Plaque Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229920001503 Glucan Polymers 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 235000002566 Capsicum Nutrition 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 239000006002 Pepper Substances 0.000 description 2
- 235000016761 Piper aduncum Nutrition 0.000 description 2
- 235000017804 Piper guineense Nutrition 0.000 description 2
- 244000203593 Piper nigrum Species 0.000 description 2
- 235000008184 Piper nigrum Nutrition 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000004097 EU approved flavor enhancer Substances 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241001528275 Eucalyptus deglupta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 235000021186 dishes Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 235000013324 preserved food Nutrition 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 235000012094 sugar confectionery Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pyrane Compounds (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22897384A JPS61109716A (ja) | 1984-11-01 | 1984-11-01 | う蝕菌生育阻害剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22897384A JPS61109716A (ja) | 1984-11-01 | 1984-11-01 | う蝕菌生育阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61109716A true JPS61109716A (ja) | 1986-05-28 |
| JPH0434968B2 JPH0434968B2 (enrdf_load_stackoverflow) | 1992-06-09 |
Family
ID=16884770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22897384A Granted JPS61109716A (ja) | 1984-11-01 | 1984-11-01 | う蝕菌生育阻害剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61109716A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287541B1 (en) * | 1998-09-23 | 2001-09-11 | Chesebrough-Pond's Usa Co., Divison Of Conopco, Inc. | Oral care compositions |
| JP2019506404A (ja) * | 2016-01-19 | 2019-03-07 | アクロマズ、プライベート、リミテッドＡｃｈｒｏｍａｚ Ｐｔｅ． Ｌｔｄ． | 化粧組成物および肌質を整えるためのその使用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5037260A (enrdf_load_stackoverflow) * | 1973-06-23 | 1975-04-07 | ||
| JPS5141446A (en) * | 1974-08-09 | 1976-04-07 | Procter & Gamble | Shiko mushiba oyobi shisekiochensaserutameno osenkeikonogenshoshitakokoyososeibutsu |
| JPS51139639A (en) * | 1975-04-01 | 1976-12-02 | Procter & Gamble | Tartar preventive composition |
| JPS568679A (en) * | 1979-04-11 | 1981-01-29 | Fichera A T | Composition for controlling tobacco smoking and production thereof |
-
1984
- 1984-11-01 JP JP22897384A patent/JPS61109716A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5037260A (enrdf_load_stackoverflow) * | 1973-06-23 | 1975-04-07 | ||
| JPS5141446A (en) * | 1974-08-09 | 1976-04-07 | Procter & Gamble | Shiko mushiba oyobi shisekiochensaserutameno osenkeikonogenshoshitakokoyososeibutsu |
| JPS51139639A (en) * | 1975-04-01 | 1976-12-02 | Procter & Gamble | Tartar preventive composition |
| JPS568679A (en) * | 1979-04-11 | 1981-01-29 | Fichera A T | Composition for controlling tobacco smoking and production thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287541B1 (en) * | 1998-09-23 | 2001-09-11 | Chesebrough-Pond's Usa Co., Divison Of Conopco, Inc. | Oral care compositions |
| JP2019506404A (ja) * | 2016-01-19 | 2019-03-07 | アクロマズ、プライベート、リミテッドＡｃｈｒｏｍａｚ Ｐｔｅ． Ｌｔｄ． | 化粧組成物および肌質を整えるためのその使用 |
| US11123279B2 (en) | 2016-01-19 | 2021-09-21 | Achromaz Pte. Ltd. | Cosmetic composition and the use thereof for regulating skin quality |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0434968B2 (enrdf_load_stackoverflow) | 1992-06-09 |
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