JPS6078580A - ビリルビン特異的酵素ならびに分析要素及び分析方法におけるそれらの使用 - Google Patents
ビリルビン特異的酵素ならびに分析要素及び分析方法におけるそれらの使用Info
- Publication number
- JPS6078580A JPS6078580A JP59180888A JP18088884A JPS6078580A JP S6078580 A JPS6078580 A JP S6078580A JP 59180888 A JP59180888 A JP 59180888A JP 18088884 A JP18088884 A JP 18088884A JP S6078580 A JPS6078580 A JP S6078580A
- Authority
- JP
- Japan
- Prior art keywords
- bilirubin
- enzyme
- conjugated
- activity
- effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 title claims description 228
- 108090000790 Enzymes Proteins 0.000 title claims description 102
- 102000004190 Enzymes Human genes 0.000 title claims description 102
- 238000004458 analytical method Methods 0.000 title claims description 21
- 230000000694 effects Effects 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 30
- 239000007788 liquid Substances 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 14
- 239000012491 analyte Substances 0.000 claims description 11
- 241000196324 Embryophyta Species 0.000 claims description 10
- 241000234280 Liliaceae Species 0.000 claims description 8
- 241000234615 Musaceae Species 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 8
- 230000002452 interceptive effect Effects 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 241000208292 Solanaceae Species 0.000 claims description 4
- 238000002845 discoloration Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 20
- 239000000523 sample Substances 0.000 description 16
- 244000061458 Solanum melongena Species 0.000 description 14
- 235000002597 Solanum melongena Nutrition 0.000 description 14
- 241000234295 Musa Species 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 238000000605 extraction Methods 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 241000234282 Allium Species 0.000 description 8
- 102000001554 Hemoglobins Human genes 0.000 description 8
- 108010054147 Hemoglobins Proteins 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- 239000012064 sodium phosphate buffer Substances 0.000 description 8
- 238000002835 absorbance Methods 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 238000006731 degradation reaction Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 5
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 description 5
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 description 5
- 210000000941 bile Anatomy 0.000 description 5
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 5
- 235000021015 bananas Nutrition 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 240000002234 Allium sativum Species 0.000 description 3
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 235000004611 garlic Nutrition 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- BPYKTIZUTYGOLE-UHFFFAOYSA-N billirubin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(C=C3C(=C(C=C)C(=O)N3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- -1 1:IV/V ethanol Chemical class 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 240000006108 Allium ampeloprasum Species 0.000 description 1
- 235000005254 Allium ampeloprasum Nutrition 0.000 description 1
- 240000006561 Allium ledebourianum Species 0.000 description 1
- 235000002186 Allium ledebourianum Nutrition 0.000 description 1
- 108010015428 Bilirubin oxidase Proteins 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000007704 wet chemistry method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/146666—Bile pigment
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US528486 | 1983-09-01 | ||
| US06/528,486 US4701411A (en) | 1983-09-01 | 1983-09-01 | Bilirubin-specific enzyme preparation, assay compositions, analytical elements and methods using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6078580A true JPS6078580A (ja) | 1985-05-04 |
| JPH0478280B2 JPH0478280B2 (esLanguage) | 1992-12-10 |
Family
ID=24105865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59180888A Granted JPS6078580A (ja) | 1983-09-01 | 1984-08-31 | ビリルビン特異的酵素ならびに分析要素及び分析方法におけるそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4701411A (esLanguage) |
| EP (1) | EP0140004B1 (esLanguage) |
| JP (1) | JPS6078580A (esLanguage) |
| CA (1) | CA1218286A (esLanguage) |
| DE (1) | DE3461104D1 (esLanguage) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3249743C2 (esLanguage) * | 1982-02-18 | 1990-10-04 | Amano Pharmaceutical Co., Ltd., Nagoya, Aichi, Jp | |
| US4746606A (en) * | 1986-05-27 | 1988-05-24 | Eastman Kodak Company | Bilirubin-specific enzyme and its analytical use |
| JP2578430B2 (ja) * | 1987-06-10 | 1997-02-05 | 旭化成工業株式会社 | 新規なビリルビン．オキシダーゼおよびその製造法 |
| EP0320095A3 (en) * | 1987-12-10 | 1989-08-02 | HEALTH & RESEARCH SERVICES INC. | Bilirubin degrading enzymes |
| US5200181A (en) * | 1988-01-11 | 1993-04-06 | Massachusetts Institute Of Technology | Oral bilirubin therapy |
| WO1989006137A1 (en) * | 1988-01-11 | 1989-07-13 | Massachusetts Institute Of Technology | Oral bilirubin therapy |
| US4937186A (en) * | 1988-01-28 | 1990-06-26 | Iqbal Siddiqi | Method for the determination of bilirubin in solution |
| JP2856757B2 (ja) * | 1989-03-13 | 1999-02-10 | ユニチカ株式会社 | 総ビリルビンの測定方法および測定用試薬 |
| DE4406379A1 (de) * | 1993-03-24 | 1994-09-29 | Boehringer Mannheim Gmbh | Bilirubinoxidase aus Alfalfa und Verwendung des Enzyms |
| US7504243B2 (en) | 2004-03-19 | 2009-03-17 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for the production of biliverdin |
| CN102148415A (zh) * | 2010-02-09 | 2011-08-10 | 黄思伦 | 香蕉植株电池 |
| TWI449237B (zh) * | 2010-02-09 | 2014-08-11 | Zzu Lun Huang | 香蕉植株電池 |
| FR2957934B1 (fr) | 2010-03-24 | 2014-10-17 | Centre Nat Rech Scient | Bilirubine oxydase de bacillus pumilus et ses applications |
| FR2975704B1 (fr) * | 2011-05-24 | 2015-02-20 | Centre Nat Rech Scient | Bilirubine oxydase de magnaporthe oryzae et ses applications |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54151193A (en) * | 1978-05-19 | 1979-11-28 | Eastman Kodak Co | Bilirubin specific bacterial enzyme composition * use and production thereof |
| JPS57159487A (en) * | 1981-03-30 | 1982-10-01 | Amano Pharmaceut Co Ltd | Preparation or bilirubin oxidase |
| JPS58141783A (ja) * | 1982-02-18 | 1983-08-23 | Amano Pharmaceut Co Ltd | ビリルビンオキシダーゼｎｓ―１ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069017A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Colorimetric assay for bilirubin |
| DE3249743C2 (esLanguage) * | 1982-02-18 | 1990-10-04 | Amano Pharmaceutical Co., Ltd., Nagoya, Aichi, Jp | |
| JPS59125899A (ja) * | 1982-12-29 | 1984-07-20 | Nippon Shoji Kk | 酵素法による直接ビリルビン測定用試薬および測定法 |
| US4600689A (en) * | 1983-11-21 | 1986-07-15 | Takara Shuzo Co., Ltd. | Novel bilirubin oxidase, its production and use |
-
1983
- 1983-09-01 US US06/528,486 patent/US4701411A/en not_active Expired - Lifetime
-
1984
- 1984-02-06 CA CA000446817A patent/CA1218286A/en not_active Expired
- 1984-08-28 EP EP84110208A patent/EP0140004B1/en not_active Expired
- 1984-08-28 DE DE8484110208T patent/DE3461104D1/de not_active Expired
- 1984-08-31 JP JP59180888A patent/JPS6078580A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54151193A (en) * | 1978-05-19 | 1979-11-28 | Eastman Kodak Co | Bilirubin specific bacterial enzyme composition * use and production thereof |
| JPS57159487A (en) * | 1981-03-30 | 1982-10-01 | Amano Pharmaceut Co Ltd | Preparation or bilirubin oxidase |
| JPS58141783A (ja) * | 1982-02-18 | 1983-08-23 | Amano Pharmaceut Co Ltd | ビリルビンオキシダーゼｎｓ―１ |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0140004A3 (en) | 1985-06-26 |
| EP0140004A2 (en) | 1985-05-08 |
| JPH0478280B2 (esLanguage) | 1992-12-10 |
| US4701411A (en) | 1987-10-20 |
| CA1218286A (en) | 1987-02-24 |
| DE3461104D1 (en) | 1986-12-04 |
| EP0140004B1 (en) | 1986-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |