CA1218286A - Bilirubin-specific enzyme preparation, assay compositions, analytical elements and methods using same - Google Patents
Bilirubin-specific enzyme preparation, assay compositions, analytical elements and methods using sameInfo
- Publication number
- CA1218286A CA1218286A CA000446817A CA446817A CA1218286A CA 1218286 A CA1218286 A CA 1218286A CA 000446817 A CA000446817 A CA 000446817A CA 446817 A CA446817 A CA 446817A CA 1218286 A CA1218286 A CA 1218286A
- Authority
- CA
- Canada
- Prior art keywords
- bilirubin
- enzyme
- isolated
- plant
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 title claims abstract description 294
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 135
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 135
- 238000002360 preparation method Methods 0.000 title claims abstract description 79
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 41
- 238000003556 assay Methods 0.000 title claims abstract description 37
- 241000196324 Embryophyta Species 0.000 claims abstract description 38
- 241000208292 Solanaceae Species 0.000 claims abstract description 22
- 244000061458 Solanum melongena Species 0.000 claims abstract description 22
- 235000002597 Solanum melongena Nutrition 0.000 claims abstract description 22
- 241000234615 Musaceae Species 0.000 claims abstract description 20
- 241000234280 Liliaceae Species 0.000 claims abstract description 19
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims abstract description 9
- 235000021015 bananas Nutrition 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 51
- 230000008859 change Effects 0.000 claims description 33
- 239000000243 solution Substances 0.000 claims description 23
- 239000012491 analyte Substances 0.000 claims description 18
- 238000006731 degradation reaction Methods 0.000 claims description 16
- 241000234282 Allium Species 0.000 claims description 13
- 230000015556 catabolic process Effects 0.000 claims description 13
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 12
- 239000003153 chemical reaction reagent Substances 0.000 claims description 12
- 230000002452 interceptive effect Effects 0.000 claims description 12
- 238000010521 absorption reaction Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 9
- 239000006228 supernatant Substances 0.000 claims description 8
- 235000002634 Solanum Nutrition 0.000 claims description 5
- 241000207763 Solanum Species 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 5
- 239000000872 buffer Substances 0.000 claims description 5
- 235000002566 Capsicum Nutrition 0.000 claims description 4
- 241000227653 Lycopersicon Species 0.000 claims description 4
- 235000002262 Lycopersicon Nutrition 0.000 claims description 4
- 241000234295 Musa Species 0.000 claims description 4
- 239000001390 capsicum minimum Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims 9
- 239000000725 suspension Substances 0.000 claims 6
- 239000012062 aqueous buffer Substances 0.000 claims 4
- 241000208293 Capsicum Species 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 2
- 238000009835 boiling Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 240000008790 Musa x paradisiaca Species 0.000 abstract description 13
- 244000061456 Solanum tuberosum Species 0.000 abstract description 4
- 235000002595 Solanum tuberosum Nutrition 0.000 abstract description 4
- 230000000593 degrading effect Effects 0.000 abstract description 4
- 244000291564 Allium cepa Species 0.000 abstract description 3
- 240000003768 Solanum lycopersicum Species 0.000 abstract description 3
- 235000007688 Lycopersicon esculentum Nutrition 0.000 abstract description 2
- 235000012015 potatoes Nutrition 0.000 abstract description 2
- 229940088598 enzyme Drugs 0.000 description 98
- 239000010410 layer Substances 0.000 description 11
- 230000009102 absorption Effects 0.000 description 9
- 230000007480 spreading Effects 0.000 description 9
- 238000003892 spreading Methods 0.000 description 9
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- 239000012064 sodium phosphate buffer Substances 0.000 description 8
- 102000001554 Hemoglobins Human genes 0.000 description 7
- 108010054147 Hemoglobins Proteins 0.000 description 7
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 description 6
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 6
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 3
- 229940079919 digestives enzyme preparation Drugs 0.000 description 3
- 230000001747 exhibiting effect Effects 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 235000005255 Allium cepa Nutrition 0.000 description 2
- 244000016163 Allium sibiricum Species 0.000 description 2
- 235000001270 Allium sibiricum Nutrition 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 240000004160 Capsicum annuum Species 0.000 description 2
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241001103808 Albifimbria verrucaria Species 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 240000006108 Allium ampeloprasum Species 0.000 description 1
- 235000005254 Allium ampeloprasum Nutrition 0.000 description 1
- 235000018714 Allium canadense Nutrition 0.000 description 1
- 240000008655 Allium cernuum Species 0.000 description 1
- 235000007626 Allium cernuum Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 235000011403 Allium vineale Nutrition 0.000 description 1
- 241000182988 Assa Species 0.000 description 1
- 108010015428 Bilirubin oxidase Proteins 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241001082241 Lythrum hyssopifolia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000291473 Musa acuminata Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 235000002560 Solanum lycopersicum Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 239000003248 enzyme activator Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000004848 polyfunctional curative Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000003375 selectivity assay Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- -1 sodium phosphate Chemical class 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000007704 wet chemistry method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/146666—Bile pigment
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/528,486 US4701411A (en) | 1983-09-01 | 1983-09-01 | Bilirubin-specific enzyme preparation, assay compositions, analytical elements and methods using same |
| US528,486 | 1983-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1218286A true CA1218286A (en) | 1987-02-24 |
Family
ID=24105865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000446817A Expired CA1218286A (en) | 1983-09-01 | 1984-02-06 | Bilirubin-specific enzyme preparation, assay compositions, analytical elements and methods using same |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4701411A (esLanguage) |
| EP (1) | EP0140004B1 (esLanguage) |
| JP (1) | JPS6078580A (esLanguage) |
| CA (1) | CA1218286A (esLanguage) |
| DE (1) | DE3461104D1 (esLanguage) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3249743C2 (esLanguage) * | 1982-02-18 | 1990-10-04 | Amano Pharmaceutical Co., Ltd., Nagoya, Aichi, Jp | |
| US4746606A (en) * | 1986-05-27 | 1988-05-24 | Eastman Kodak Company | Bilirubin-specific enzyme and its analytical use |
| JP2578430B2 (ja) * | 1987-06-10 | 1997-02-05 | 旭化成工業株式会社 | 新規なビリルビン．オキシダーゼおよびその製造法 |
| EP0320095A3 (en) * | 1987-12-10 | 1989-08-02 | HEALTH & RESEARCH SERVICES INC. | Bilirubin degrading enzymes |
| US5200181A (en) * | 1988-01-11 | 1993-04-06 | Massachusetts Institute Of Technology | Oral bilirubin therapy |
| WO1989006137A1 (en) * | 1988-01-11 | 1989-07-13 | Massachusetts Institute Of Technology | Oral bilirubin therapy |
| US4937186A (en) * | 1988-01-28 | 1990-06-26 | Iqbal Siddiqi | Method for the determination of bilirubin in solution |
| JP2856757B2 (ja) * | 1989-03-13 | 1999-02-10 | ユニチカ株式会社 | 総ビリルビンの測定方法および測定用試薬 |
| DE4406379A1 (de) * | 1993-03-24 | 1994-09-29 | Boehringer Mannheim Gmbh | Bilirubinoxidase aus Alfalfa und Verwendung des Enzyms |
| US7504243B2 (en) | 2004-03-19 | 2009-03-17 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for the production of biliverdin |
| CN102148415A (zh) * | 2010-02-09 | 2011-08-10 | 黄思伦 | 香蕉植株电池 |
| TWI449237B (zh) * | 2010-02-09 | 2014-08-11 | Zzu Lun Huang | 香蕉植株電池 |
| FR2957934B1 (fr) | 2010-03-24 | 2014-10-17 | Centre Nat Rech Scient | Bilirubine oxydase de bacillus pumilus et ses applications |
| FR2975704B1 (fr) * | 2011-05-24 | 2015-02-20 | Centre Nat Rech Scient | Bilirubine oxydase de magnaporthe oryzae et ses applications |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069017A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Colorimetric assay for bilirubin |
| US4211844A (en) * | 1978-05-19 | 1980-07-08 | Eastman Kodak Company | Bilirubin-specific fungal enzyme preparation |
| JPS6012031B2 (ja) * | 1981-03-30 | 1985-03-29 | 天野製薬株式会社 | ビリルビンオキシダ−ゼの製造法 |
| JPS6012032B2 (ja) * | 1982-02-18 | 1985-03-29 | 天野製薬株式会社 | ビリルビンオキシダーゼｎｓ―１ |
| DE3249743C2 (esLanguage) * | 1982-02-18 | 1990-10-04 | Amano Pharmaceutical Co., Ltd., Nagoya, Aichi, Jp | |
| JPS59125899A (ja) * | 1982-12-29 | 1984-07-20 | Nippon Shoji Kk | 酵素法による直接ビリルビン測定用試薬および測定法 |
| US4600689A (en) * | 1983-11-21 | 1986-07-15 | Takara Shuzo Co., Ltd. | Novel bilirubin oxidase, its production and use |
-
1983
- 1983-09-01 US US06/528,486 patent/US4701411A/en not_active Expired - Lifetime
-
1984
- 1984-02-06 CA CA000446817A patent/CA1218286A/en not_active Expired
- 1984-08-28 EP EP84110208A patent/EP0140004B1/en not_active Expired
- 1984-08-28 DE DE8484110208T patent/DE3461104D1/de not_active Expired
- 1984-08-31 JP JP59180888A patent/JPS6078580A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0140004A3 (en) | 1985-06-26 |
| EP0140004A2 (en) | 1985-05-08 |
| JPH0478280B2 (esLanguage) | 1992-12-10 |
| US4701411A (en) | 1987-10-20 |
| DE3461104D1 (en) | 1986-12-04 |
| EP0140004B1 (en) | 1986-10-29 |
| JPS6078580A (ja) | 1985-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |