JPS6056922A - 硫酸コンドロイチン／ヒアルロン酸金属塩組成物 - Google Patents
硫酸コンドロイチン／ヒアルロン酸金属塩組成物Info
- Publication number
- JPS6056922A JPS6056922A JP59158525A JP15852584A JPS6056922A JP S6056922 A JPS6056922 A JP S6056922A JP 59158525 A JP59158525 A JP 59158525A JP 15852584 A JP15852584 A JP 15852584A JP S6056922 A JPS6056922 A JP S6056922A
- Authority
- JP
- Japan
- Prior art keywords
- chondroitin sulfate
- hyaluronate
- salt
- hyaluronic acid
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 title claims description 88
- 229920001287 Chondroitin sulfate Polymers 0.000 title claims description 88
- 229940059329 chondroitin sulfate Drugs 0.000 title claims description 88
- 239000000203 mixture Substances 0.000 title claims description 49
- 229910052751 metal Inorganic materials 0.000 title claims description 45
- 239000002184 metal Substances 0.000 title claims description 45
- 150000003839 salts Chemical class 0.000 title claims description 28
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims description 22
- 229920002674 hyaluronan Polymers 0.000 title claims description 22
- 229960003160 hyaluronic acid Drugs 0.000 title claims description 22
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 41
- 229940014041 hyaluronate Drugs 0.000 claims description 41
- 239000000243 solution Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 23
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 18
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 18
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 208000014674 injury Diseases 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 12
- 230000008736 traumatic injury Effects 0.000 claims description 10
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 7
- 239000011777 magnesium Substances 0.000 claims description 7
- 229910052749 magnesium Inorganic materials 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 6
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- 239000011591 potassium Substances 0.000 claims description 6
- 229910052700 potassium Inorganic materials 0.000 claims description 6
- 159000000000 sodium salts Chemical group 0.000 claims description 6
- 159000000007 calcium salts Chemical class 0.000 claims description 5
- 230000001747 exhibiting effect Effects 0.000 claims description 4
- -1 salt hyaluronate Chemical class 0.000 claims description 2
- 159000000003 magnesium salts Chemical class 0.000 claims 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 4
- 230000003993 interaction Effects 0.000 description 16
- 229920000609 methyl cellulose Polymers 0.000 description 10
- 239000001923 methylcellulose Substances 0.000 description 10
- 235000010981 methylcellulose Nutrition 0.000 description 10
- 239000000872 buffer Substances 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 5
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical group CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 210000000399 corneal endothelial cell Anatomy 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 210000004087 cornea Anatomy 0.000 description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000012062 aqueous buffer Substances 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 159000000001 potassium salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 210000000871 endothelium corneal Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52157583A | 1983-08-09 | 1983-08-09 | |
| US521575 | 1983-08-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6056922A true JPS6056922A (ja) | 1985-04-02 |
| JPH0121133B2 JPH0121133B2 (https=) | 1989-04-19 |
Family
ID=24077252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59158525A Granted JPS6056922A (ja) | 1983-08-09 | 1984-07-27 | 硫酸コンドロイチン／ヒアルロン酸金属塩組成物 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0136782B1 (https=) |
| JP (1) | JPS6056922A (https=) |
| AU (1) | AU555747B2 (https=) |
| CA (1) | CA1240929A (https=) |
| DE (1) | DE3485588D1 (https=) |
| FI (1) | FI82605C (https=) |
| ZA (1) | ZA845995B (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61236732A (ja) * | 1985-04-05 | 1986-10-22 | フイデイ−ア・ソシエタ・ペル・アチオニ | 新規医薬組成物 |
| JPS635745A (ja) * | 1986-04-04 | 1988-01-11 | アラ−ガン・インコ−ポレイテツド | 角膜創傷治癒用組成物 |
| JPH01294633A (ja) * | 1988-05-23 | 1989-11-28 | Fujisawa Pharmaceut Co Ltd | 点眼剤 |
| JP2009538287A (ja) * | 2006-05-26 | 2009-11-05 | アルテルゴン エス．エイ． | 低粘度グリコサミノグリカンで構成される組成及び該組成の間質性膀胱炎の治療での使用 |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| US5541166A (en) * | 1987-01-23 | 1996-07-30 | The Australian National University | Sulphated polysaccharides having anti-metastatic and/or anti-inflammatory activity |
| IL85145A (en) * | 1987-01-23 | 1994-08-26 | Univ Australian | Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity |
| US5668116A (en) * | 1987-03-19 | 1997-09-16 | Anthropharm Pty. Limited | Anti-inflammatory compounds and compositions |
| AU604542B2 (en) * | 1987-03-19 | 1990-12-20 | Arthropharm Pty Ltd | Polysulphated polysaccharide complexes |
| DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| US5908836A (en) * | 1987-12-21 | 1999-06-01 | Bar-Shalom; Daniel | Protecting skin from radiation damage using sulphated sugars |
| US5510329A (en) * | 1988-04-26 | 1996-04-23 | Ramot University For Applied Research And Industrial Development Ltd. | Preparations for the treatment of eyes |
| US6271216B1 (en) | 1989-07-24 | 2001-08-07 | Allergan | Stable solution of hyaluronate in a balanced salt medium |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| US5627162A (en) * | 1990-01-11 | 1997-05-06 | Gwon; Arlene E. | Methods and means for control of proliferation of remnant cells following surgery |
| US5990096A (en) * | 1990-09-18 | 1999-11-23 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US5824658A (en) * | 1990-09-18 | 1998-10-20 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| CA2061703C (en) * | 1992-02-20 | 2002-07-02 | Rudolf E. Falk | Formulations containing hyaluronic acid |
| US5639738A (en) * | 1992-02-20 | 1997-06-17 | Hyal Pharmaceutical Corporation | Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs |
| US5910489A (en) * | 1990-09-18 | 1999-06-08 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| KR940011725B1 (ko) * | 1990-11-28 | 1994-12-23 | 가부시키가이샤 도시바 | 회전양극형 x선관의 제조방법 및 제조장치 |
| US5492936A (en) * | 1990-11-30 | 1996-02-20 | Allergan, Inc. | Bimodal molecular weight hyaluronate formulations and methods for using same |
| US5977088A (en) * | 1991-07-03 | 1999-11-02 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| WO1994007505A1 (en) * | 1991-07-03 | 1994-04-14 | Norpharmco Inc. | Use of hyaluronic acid and forms to prevent arterial restenosis |
| US6103704A (en) * | 1991-07-03 | 2000-08-15 | Hyal Pharmaceutical Corporation | Therapeutic methods using hyaluronic acid |
| US5792753A (en) * | 1991-07-03 | 1998-08-11 | Hyal Pharmaceutical Corporation | Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs |
| US5990095A (en) * | 1991-07-03 | 1999-11-23 | Hyal Pharmaceutical Corporation | Use of hyaluronic acid and forms to prevent arterial restenosis |
| US5817644A (en) * | 1991-07-03 | 1998-10-06 | Hyal Pharmaceutical Corporation | Targeting of dosages of medicine and therapeutic agents |
| US6022866A (en) * | 1991-07-03 | 2000-02-08 | Hyal Pharmaceutical Corporation | Use of hyaluronic acid and forms to prevent arterial restenosis |
| CA2061567C (en) * | 1992-02-20 | 1998-02-03 | Rudolf E. Falk | Use of hyaluronic acid to repair ischemia reperfusion damage |
| US6218373B1 (en) | 1992-02-20 | 2001-04-17 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US6136793A (en) * | 1992-02-20 | 2000-10-24 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US5767106A (en) * | 1992-02-21 | 1998-06-16 | Hyal Pharmaceutical Corporation | Treatment of disease and conditions associated with macrophage infiltration |
| US6114314A (en) * | 1992-02-21 | 2000-09-05 | Hyal Pharmaceutical Corp. | Formulations containing hyaluronic acid |
| US5273056A (en) * | 1992-06-12 | 1993-12-28 | Alcon Laboratories, Inc. | Use of combinations of viscoelastics during surgery |
| US6083933A (en) * | 1999-04-19 | 2000-07-04 | Stellar International Inc. | Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution |
| US20040118414A1 (en) | 2002-12-20 | 2004-06-24 | Shah Mandar V | Surface modified viscoelastics for ocular surgery |
| US7820194B2 (en) * | 2001-12-21 | 2010-10-26 | Alcon, Inc. | Combinations of viscoelastics for use during surgery |
| US7363928B2 (en) | 2001-12-21 | 2008-04-29 | Alcon, Inc. | Dilution resistant viscoelastic compositions |
| WO2003059391A2 (en) * | 2001-12-21 | 2003-07-24 | Alcon, Inc. | Viscoelastics for ocular surgery |
| US20040161476A1 (en) | 2003-02-19 | 2004-08-19 | Hahn Sungtack Samuel | Cystitis treatment with high dose chondroitin sulfate |
| ES2706848T3 (es) | 2004-07-06 | 2019-04-01 | Zymogenetics Inc | Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso |
| US7939511B2 (en) | 2004-09-28 | 2011-05-10 | Senju Pharmaceutical Co., Ltd. | Ophthalmic composition containing xanthan gum and amino acid |
| WO2007008206A1 (en) * | 2005-07-11 | 2007-01-18 | Alcon, Inc. | Dilution resistant viscoelastic compositions |
| CN101522164B (zh) | 2006-09-13 | 2014-03-26 | 提升肤质产品公司 | 用于治疗皮肤的化妆品组合物及其方法 |
| DE102006049580A1 (de) * | 2006-10-20 | 2008-04-24 | Rochel, Michael, Dr. med. | Topische Zusammensetzung zur Behandlung von Ekzemen |
| PL2296670T3 (pl) | 2008-05-13 | 2013-07-31 | Apharm Srl | Doustne zastosowanie glikozaminoglikanu i kompozycje |
| EP2435021B1 (en) | 2009-05-25 | 2013-07-03 | Pharcoterm S.R.L. | Use of a glycosaminoglycan fixed combination and chewable composition comprising said fixed combination |
| PL2596796T3 (pl) | 2011-11-24 | 2014-04-30 | Quimera Ingenieria Biomedica S L | Kompleks otrzymany z mieszanin kwasu hialuronowego lub jego soli z siarczanem chondroityny |
| EP2886104A1 (en) * | 2013-12-11 | 2015-06-24 | Patir, Suleyman | An intra-articular gel |
| US20190008891A1 (en) | 2016-01-29 | 2019-01-10 | Seikagaku Corporation | Stabilized aqueous composition comprising chondroitin sulfate and hyaluronic acid |
| CZ33324U1 (cs) | 2019-09-06 | 2019-10-25 | Contipro A.S. | Hydrogel na bázi zesíťovaného hydroxyfenylového derivátu kyseliny hyaluronové |
| US12016855B2 (en) | 2020-08-26 | 2024-06-25 | Somerset Therapeutics, Llc | Prednisolone and moxifloxacin compositions and methods |
| US12102632B2 (en) * | 2020-08-26 | 2024-10-01 | Somerset Therapeutics, Llc | Quinolone dispersions |
-
1984
- 1984-07-18 AU AU30806/84A patent/AU555747B2/en not_active Expired
- 1984-07-27 JP JP59158525A patent/JPS6056922A/ja active Granted
- 1984-08-01 DE DE8484305221T patent/DE3485588D1/de not_active Expired - Lifetime
- 1984-08-01 EP EP84305221A patent/EP0136782B1/en not_active Expired - Lifetime
- 1984-08-02 ZA ZA845995A patent/ZA845995B/xx unknown
- 1984-08-03 CA CA000460409A patent/CA1240929A/en not_active Expired
- 1984-08-08 FI FI843122A patent/FI82605C/fi not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61236732A (ja) * | 1985-04-05 | 1986-10-22 | フイデイ−ア・ソシエタ・ペル・アチオニ | 新規医薬組成物 |
| JPS635745A (ja) * | 1986-04-04 | 1988-01-11 | アラ−ガン・インコ−ポレイテツド | 角膜創傷治癒用組成物 |
| JPH01294633A (ja) * | 1988-05-23 | 1989-11-28 | Fujisawa Pharmaceut Co Ltd | 点眼剤 |
| JP2009538287A (ja) * | 2006-05-26 | 2009-11-05 | アルテルゴン エス．エイ． | 低粘度グリコサミノグリカンで構成される組成及び該組成の間質性膀胱炎の治療での使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0136782A3 (en) | 1986-07-02 |
| FI82605B (fi) | 1990-12-31 |
| CA1240929A (en) | 1988-08-23 |
| JPH0121133B2 (https=) | 1989-04-19 |
| EP0136782A2 (en) | 1985-04-10 |
| FI843122A0 (fi) | 1984-08-08 |
| DE3485588D1 (de) | 1992-04-23 |
| FI82605C (fi) | 1991-04-10 |
| AU555747B2 (en) | 1986-10-09 |
| AU3080684A (en) | 1985-02-14 |
| ZA845995B (en) | 1985-10-30 |
| FI843122L (fi) | 1985-02-10 |
| EP0136782B1 (en) | 1992-03-18 |
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