JPS6054306B2 - ニコチンアミド製造法 - Google Patents
ニコチンアミド製造法Info
- Publication number
- JPS6054306B2 JPS6054306B2 JP56060524A JP6052481A JPS6054306B2 JP S6054306 B2 JPS6054306 B2 JP S6054306B2 JP 56060524 A JP56060524 A JP 56060524A JP 6052481 A JP6052481 A JP 6052481A JP S6054306 B2 JPS6054306 B2 JP S6054306B2
- Authority
- JP
- Japan
- Prior art keywords
- nicotinonitrile
- ammonia
- nicotinamide
- hydrolysis
- overhead
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title claims description 48
- 235000005152 nicotinamide Nutrition 0.000 title claims description 24
- 239000011570 nicotinamide Substances 0.000 title claims description 24
- 229960003966 nicotinamide Drugs 0.000 title claims description 24
- 238000004519 manufacturing process Methods 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 60
- GZPHSAQLYPIAIN-UHFFFAOYSA-N 3-pyridinecarbonitrile Chemical compound N#CC1=CC=CN=C1 GZPHSAQLYPIAIN-UHFFFAOYSA-N 0.000 claims description 36
- 229910021529 ammonia Inorganic materials 0.000 claims description 28
- 230000007062 hydrolysis Effects 0.000 claims description 22
- 238000006460 hydrolysis reaction Methods 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 12
- ONJIBHRZSUEBDS-UHFFFAOYSA-N azane;pyridine-3-carboxylic acid Chemical compound [NH4+].[O-]C(=O)C1=CC=CN=C1 ONJIBHRZSUEBDS-UHFFFAOYSA-N 0.000 claims description 8
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 2
- 230000003301 hydrolyzing effect Effects 0.000 claims description 2
- 238000004064 recycling Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 description 8
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 150000002825 nitriles Chemical class 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011552 falling film Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/141,943 US4327219A (en) | 1980-04-21 | 1980-04-21 | Nicotinamide production |
| US141943 | 1980-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56166174A JPS56166174A (en) | 1981-12-21 |
| JPS6054306B2 true JPS6054306B2 (ja) | 1985-11-29 |
Family
ID=22497912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56060524A Expired JPS6054306B2 (ja) | 1980-04-21 | 1981-04-20 | ニコチンアミド製造法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4327219A (https=) |
| JP (1) | JPS6054306B2 (https=) |
| CA (1) | CA1130293A (https=) |
| CH (1) | CH648830A5 (https=) |
| DE (1) | DE3114989A1 (https=) |
| DK (1) | DK177081A (https=) |
| FR (1) | FR2480750A1 (https=) |
| GB (1) | GB2074162B (https=) |
| IT (1) | IT8148278A0 (https=) |
| NL (1) | NL8101948A (https=) |
| SE (1) | SE436030B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3244522A1 (de) * | 1982-12-02 | 1984-06-07 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von nicotinsaeureamid |
| EP1021408A1 (en) * | 1996-02-09 | 2000-07-26 | Reilly Industries, Inc. | Continuous processes for the hydrolysis of cyanopyridines under substantially adiabatic conditions |
| BR112016029756B1 (pt) | 2014-06-27 | 2021-05-04 | Agro-Kanesho Co., Ltd | método para produzir um composto |
| CN104815455B (zh) * | 2015-04-10 | 2016-02-24 | 南阳师范学院 | 水蒸气蒸馏法提取烟碱用的进料装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2427400A (en) * | 1942-06-25 | 1947-09-16 | Paul W Garbo | Process for the manufacture of nicotinamide |
| DE2517053A1 (de) * | 1975-04-17 | 1976-10-28 | Degussa | Verfahren zur gewinnung von nicotinsaeureamid |
| US4008241A (en) * | 1975-09-02 | 1977-02-15 | The Lummus Company | Nicotinamide production |
-
1980
- 1980-04-21 US US06/141,943 patent/US4327219A/en not_active Expired - Lifetime
-
1981
- 1981-04-14 IT IT8148278A patent/IT8148278A0/it unknown
- 1981-04-14 DE DE19813114989 patent/DE3114989A1/de not_active Withdrawn
- 1981-04-16 SE SE8102469A patent/SE436030B/sv unknown
- 1981-04-16 CH CH2574/81A patent/CH648830A5/de not_active IP Right Cessation
- 1981-04-16 GB GB8112228A patent/GB2074162B/en not_active Expired
- 1981-04-16 CA CA375,697A patent/CA1130293A/en not_active Expired
- 1981-04-17 FR FR8107778A patent/FR2480750A1/fr active Granted
- 1981-04-20 JP JP56060524A patent/JPS6054306B2/ja not_active Expired
- 1981-04-21 NL NL8101948A patent/NL8101948A/nl not_active Application Discontinuation
- 1981-04-21 DK DK177081A patent/DK177081A/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE8102469L (sv) | 1981-10-22 |
| SE436030B (sv) | 1984-11-05 |
| DK177081A (da) | 1981-10-22 |
| US4327219A (en) | 1982-04-27 |
| FR2480750B1 (https=) | 1984-12-28 |
| IT8148278A0 (it) | 1981-04-14 |
| NL8101948A (nl) | 1981-11-16 |
| GB2074162B (en) | 1984-02-22 |
| FR2480750A1 (fr) | 1981-10-23 |
| DE3114989A1 (de) | 1982-04-29 |
| JPS56166174A (en) | 1981-12-21 |
| CA1130293A (en) | 1982-08-24 |
| GB2074162A (en) | 1981-10-28 |
| CH648830A5 (de) | 1985-04-15 |
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