JPS60501106A - ５−エチニル−プロスタサイクリン、その製法及びその薬剤学的使用 - Google Patents

５−エチニル−プロスタサイクリン、その製法及びその薬剤学的使用

Info

Publication number
JPS60501106A
JPS60501106A JP50212284A JP50212284A JPS60501106A JP S60501106 A JPS60501106 A JP S60501106A JP 50212284 A JP50212284 A JP 50212284A JP 50212284 A JP50212284 A JP 50212284A JP S60501106 A JPS60501106 A JP S60501106A
Authority
JP
Japan
Prior art keywords
group
ethynyl
methyl
general formula
prostacyclin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP50212284A
Other languages
English (en)
Japanese (ja)
Inventor
フオアブリユツゲン，ヘルムート
ラーデユヒエル，ベルント
スクバラ，ヴエルナー
シユテユルツエベツヒヤー，クラウス‐シユテフエン
ハーベライ，マルチン
Original Assignee
シエ−リング　アクチエンゲゼルシヤフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シエ−リング　アクチエンゲゼルシヤフト filed Critical シエ−リング　アクチエンゲゼルシヤフト
Publication of JPS60501106A publication Critical patent/JPS60501106A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP50212284A 1983-04-20 1984-04-17 ５−エチニル−プロスタサイクリン、その製法及びその薬剤学的使用 Pending JPS60501106A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3314207.6 1983-04-20
DE19833314207 DE3314207A1 (de) 1983-04-20 1983-04-20 5-aethinyl-prostacycline, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung

Publications (1)

Publication Number Publication Date
JPS60501106A true JPS60501106A (ja) 1985-07-18

Family

ID=6196807

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50212284A Pending JPS60501106A (ja) 1983-04-20 1984-04-17 ５−エチニル−プロスタサイクリン、その製法及びその薬剤学的使用

Country Status (4)

Country Link
EP (1) EP0139731A1 (de)
JP (1) JPS60501106A (de)
DE (1) DE3314207A1 (de)
WO (1) WO1984004307A1 (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038308A (en) * 1976-09-13 1977-07-26 American Home Products Corporation Prostaglandin derivatives
DE2809733A1 (de) * 1978-03-03 1979-09-13 Schering Ag Neue prostacyclinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DE3314207A1 (de) 1984-10-25
EP0139731A1 (de) 1985-05-08
WO1984004307A1 (en) 1984-11-08

Similar Documents

Publication Publication Date Title
CA1309087C (en) Cyclodextrin clathrates of carbacyclin derivatives and their use as medicinal agents
US4567195A (en) Azaprostacyclins, their preparation and pharmaceutical use
US4708963A (en) Novel carbacyclins, their preparation and use
US4191694A (en) Prostaglandin-I2 derivatives
EP0024943B1 (de) 5,6,7-Trinor-4,8-inter-m-phenylen-PGI2-Derivate und sie enthaltende pharmazeutische Zusammensetzungen
JPS61500787A (ja) ９―ハロゲン―δ２―プロスタン誘導体及びその製法
JPS59157050A (ja) （５Ｅ）↓−１３，１４，１８，１８，１９，１９↓−ヘキサデヒドロ↓−３↓−オキサ↓−６ａ↓−カルバプロスタグランジン↓−Ｉ↓２↓−誘導体、その製法並びに該化合物を含有する血圧降下剤
JPS5921636A (ja) 新規カルバシクリン誘導体及びその製法
JPS60501106A (ja) ５−エチニル−プロスタサイクリン、その製法及びその薬剤学的使用
CA1252088A (en) Prostacyclin derivatives, process for the preparation thereof, and use thereof as medicinal agents
JPH0342259B2 (de)
JPS59210044A (ja) プロスタサイクリン類の製法
JPS59500471A (ja) 新規のカルバシクリン及びその製造法
JPS61502823A (ja) 新規カルバサイクリン、その製造方法及び該化合物の薬剤としての利用
JPS58225041A (ja) 新規カルバシクリンエステル、その製法及び該エステルを含有する降圧作用を有する医薬
JPH0451537B2 (de)
CA1326022C (en) 6-oxoprostaglandin-e derivatives, method for their manufacture and their use as pharmaceuticals
HU191197B (en) Process for preparing new carbacycline derivatives and pharmaceutical compositions containing thereof
JPS6219565A (ja) ３―チアカルバサイクリン類
JPS604154A (ja) １３−アザトロンボキサン類似化合物、その製造方法及びその化合物を有効成分として含有するトロンボキサン起因疾患治療剤
JPS63501871A (ja) 新規カルバサイクリン、その製法および薬剤としてのその使用
JPS60188336A (ja) 新規カルバサイクリン、その製法及びこれを含有する細胞保護剤
JPS59134739A (ja) ５―フルオルカルバシクリン及びその製法
US5124343A (en) Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents
DE4037941A1 (de) Cyclopentanetherderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung