JPS60215003A - キトサン成形体の製造方法 - Google Patents
キトサン成形体の製造方法Info
- Publication number
- JPS60215003A JPS60215003A JP59072223A JP7222384A JPS60215003A JP S60215003 A JPS60215003 A JP S60215003A JP 59072223 A JP59072223 A JP 59072223A JP 7222384 A JP7222384 A JP 7222384A JP S60215003 A JPS60215003 A JP S60215003A
- Authority
- JP
- Japan
- Prior art keywords
- chitosan
- solution
- granular
- molding
- coagulation bath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 92
- 238000004519 manufacturing process Methods 0.000 title claims description 11
- 238000000465 moulding Methods 0.000 title abstract description 8
- 230000015271 coagulation Effects 0.000 claims abstract description 17
- 238000005345 coagulation Methods 0.000 claims abstract description 17
- 230000001112 coagulating effect Effects 0.000 claims abstract description 5
- 229920002101 Chitin Polymers 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract description 10
- 239000002184 metal Substances 0.000 abstract description 10
- 229910052751 metal Inorganic materials 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 229960000583 acetic acid Drugs 0.000 abstract description 4
- 239000002738 chelating agent Substances 0.000 abstract description 4
- 239000003463 adsorbent Substances 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 238000005342 ion exchange Methods 0.000 abstract description 3
- 102000004190 Enzymes Human genes 0.000 abstract description 2
- 108090000790 Enzymes Proteins 0.000 abstract description 2
- 239000013543 active substance Substances 0.000 abstract description 2
- 238000001042 affinity chromatography Methods 0.000 abstract description 2
- 239000012362 glacial acetic acid Substances 0.000 abstract description 2
- 239000000701 coagulant Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000003100 immobilizing effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 20
- 238000000034 method Methods 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 125000003277 amino group Chemical group 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000006640 acetylation reaction Methods 0.000 description 3
- 230000010933 acylation Effects 0.000 description 3
- 238000005917 acylation reaction Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 235000011054 acetic acid Nutrition 0.000 description 2
- 230000021736 acetylation Effects 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Treatment Of Water By Ion Exchange (AREA)
- Water Treatment By Sorption (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59072223A JPS60215003A (ja) | 1984-04-10 | 1984-04-10 | キトサン成形体の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59072223A JPS60215003A (ja) | 1984-04-10 | 1984-04-10 | キトサン成形体の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60215003A true JPS60215003A (ja) | 1985-10-28 |
| JPH0578578B2 JPH0578578B2 (en, 2012) | 1993-10-29 |
Family
ID=13483037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59072223A Granted JPS60215003A (ja) | 1984-04-10 | 1984-04-10 | キトサン成形体の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60215003A (en, 2012) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62190110A (ja) * | 1986-02-15 | 1987-08-20 | Fuji Boseki Kk | キトサン配合化粧料 |
| JPH02225539A (ja) * | 1989-02-27 | 1990-09-07 | Fuji Spinning Co Ltd | 多孔質キトサン成形物の製造法 |
| JPH0482892A (ja) * | 1990-07-20 | 1992-03-16 | Taiyo Sanso Co Ltd | 高純度アルコキシシランの製造方法 |
| US6599720B2 (en) | 1993-12-01 | 2003-07-29 | Marine Polymer Technologies | Methods for making poly-β-1→4-N-acetylglucosamine |
| JP2005081278A (ja) * | 2003-09-09 | 2005-03-31 | Univ Nihon | キトサンビーズを用いたフェノール系化合物の吸着除去方法 |
| JP2008544847A (ja) * | 2005-07-06 | 2008-12-11 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 分離マトリックスの製造方法 |
| CN102352047A (zh) * | 2011-06-27 | 2012-02-15 | 张会艳 | 一种甲壳素球的制备方法 |
| US8858964B2 (en) | 2010-04-15 | 2014-10-14 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly-N-acetylglucosamine nanofibers |
| US8871247B2 (en) | 2007-02-19 | 2014-10-28 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| US10765698B2 (en) | 2011-04-15 | 2020-09-08 | Marine Polymer Technologies, Inc. | Treatment of disease with poly-N-acetylglucosamine nanofibers |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4860753A (en, 2012) * | 1971-12-03 | 1973-08-25 | ||
| JPS515834A (ja) * | 1974-07-02 | 1976-01-19 | Sumitomo Chemical Co | Ankyohaisuihoho |
| JPS5590503A (en) * | 1978-12-29 | 1980-07-09 | Kureha Chem Ind Co Ltd | Chitin molding material |
| JPS56106901A (en) * | 1980-01-30 | 1981-08-25 | Mitsubishi Rayon Co Ltd | Production of formed product of chitosan |
| JPS5829801A (ja) * | 1981-08-13 | 1983-02-22 | Agency Of Ind Science & Technol | Ｎ−アシル化キトサンの製造方法 |
| JPS5857401A (ja) * | 1981-09-30 | 1983-04-05 | Agency Of Ind Science & Technol | 粉粒状多孔質キトサンの製造方法 |
-
1984
- 1984-04-10 JP JP59072223A patent/JPS60215003A/ja active Granted
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4860753A (en, 2012) * | 1971-12-03 | 1973-08-25 | ||
| JPS515834A (ja) * | 1974-07-02 | 1976-01-19 | Sumitomo Chemical Co | Ankyohaisuihoho |
| JPS5590503A (en) * | 1978-12-29 | 1980-07-09 | Kureha Chem Ind Co Ltd | Chitin molding material |
| JPS56106901A (en) * | 1980-01-30 | 1981-08-25 | Mitsubishi Rayon Co Ltd | Production of formed product of chitosan |
| JPS5829801A (ja) * | 1981-08-13 | 1983-02-22 | Agency Of Ind Science & Technol | Ｎ−アシル化キトサンの製造方法 |
| JPS5857401A (ja) * | 1981-09-30 | 1983-04-05 | Agency Of Ind Science & Technol | 粉粒状多孔質キトサンの製造方法 |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62190110A (ja) * | 1986-02-15 | 1987-08-20 | Fuji Boseki Kk | キトサン配合化粧料 |
| JPH02225539A (ja) * | 1989-02-27 | 1990-09-07 | Fuji Spinning Co Ltd | 多孔質キトサン成形物の製造法 |
| JPH0482892A (ja) * | 1990-07-20 | 1992-03-16 | Taiyo Sanso Co Ltd | 高純度アルコキシシランの製造方法 |
| US6599720B2 (en) | 1993-12-01 | 2003-07-29 | Marine Polymer Technologies | Methods for making poly-β-1→4-N-acetylglucosamine |
| US6610668B2 (en) | 1993-12-01 | 2003-08-26 | Marine Polymers Technologies | Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system |
| US6630459B2 (en) | 1993-12-01 | 2003-10-07 | Marine Polymers Technologies | Pharmaceutical compositions comprising poly-β-1→4-N-acetylglucosamine |
| US6649599B2 (en) | 1993-12-01 | 2003-11-18 | Marine Polymer Technologies, Inc. | Methods and compositions for poly-β-1-4-N-acetylglucosamine cell therapy system |
| US6686342B2 (en) | 1993-12-01 | 2004-02-03 | Marine Polymer Technologies, Inc. | Bicompatible poly-β-1→4-N-acetylglucosamine |
| US6864245B2 (en) | 1993-12-01 | 2005-03-08 | Marine Polymer Technologies, Inc. | Biocompatible poly-β-1→4-N-acetylglucosamine |
| JP2005081278A (ja) * | 2003-09-09 | 2005-03-31 | Univ Nihon | キトサンビーズを用いたフェノール系化合物の吸着除去方法 |
| JP2008544847A (ja) * | 2005-07-06 | 2008-12-11 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 分離マトリックスの製造方法 |
| US8871247B2 (en) | 2007-02-19 | 2014-10-28 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| US9139663B2 (en) | 2007-02-19 | 2015-09-22 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| US9139664B2 (en) | 2007-02-19 | 2015-09-22 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| US10383971B2 (en) | 2007-02-19 | 2019-08-20 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| US8858964B2 (en) | 2010-04-15 | 2014-10-14 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly-N-acetylglucosamine nanofibers |
| US9198928B2 (en) | 2010-04-15 | 2015-12-01 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly-N-acetylglucosamine nanofibers |
| US9642871B2 (en) | 2010-04-15 | 2017-05-09 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly-N-acetylglucosamine nanofibers |
| US10206938B2 (en) | 2010-04-15 | 2019-02-19 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly-N-acetylglucosamine nanofibers |
| US10561677B2 (en) | 2010-04-15 | 2020-02-18 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly-N-acetylglucosamine nanofibers |
| US10765698B2 (en) | 2011-04-15 | 2020-09-08 | Marine Polymer Technologies, Inc. | Treatment of disease with poly-N-acetylglucosamine nanofibers |
| CN102352047A (zh) * | 2011-06-27 | 2012-02-15 | 张会艳 | 一种甲壳素球的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0578578B2 (en, 2012) | 1993-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Fatullayeva et al. | Recent advances of chitosan-based polymers in biomedical applications and environmental protection | |
| Boominathan et al. | Recent advances in the synthesis, properties, and applications of modified chitosan derivatives: challenges and opportunities | |
| CN105494430B (zh) | 一种载银低分子量壳聚糖复合微球抗菌剂及其制备方法 | |
| JPS6320301A (ja) | キトサン微小粒体 | |
| Al-Helw et al. | Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone | |
| WO2020121805A1 (ja) | セルロースビーズの製造方法 | |
| CN101724163B (zh) | 一种壳聚糖衍生物复合微球及其制备方法和应用 | |
| JPS60215003A (ja) | キトサン成形体の製造方法 | |
| Ghorab et al. | Preparation of controlled release anticancer agents I: 5-fluorouracil-ethyl cellulose microspheres | |
| CN107714674A (zh) | 一种plga微球的制备方法 | |
| JPS5930722B2 (ja) | 粉粒状多孔質キトサンの製造方法 | |
| JPH08283457A (ja) | 球状セルロース及びその製造法 | |
| JPS6176504A (ja) | 粒状多孔質キトサンの製造法 | |
| Misirli et al. | Preparation and characterization of Mitomycin-C loaded chitosan-coated alginate microspheres for chemoembolization | |
| US4948814A (en) | Ion exchanger based on cross-linked glucomannan | |
| JPS6354286B2 (en, 2012) | ||
| Lee et al. | Preparation and characterization of melatonin-loaded stearyl alcohol microspheres | |
| NO873184L (no) | Polymer behandlede jone bytte harpiks. | |
| JPH0623202B2 (ja) | キトサン粒体の製造方法 | |
| JPH04210239A (ja) | 吸着剤およびその製造方法 | |
| JPS6317902A (ja) | キトサン粒体の製造方法 | |
| JPH0578577B2 (en, 2012) | ||
| KR20020033774A (ko) | 빠르게 분해되는 키토산을 기재로 하는 펠렛 | |
| CN111388445A (zh) | 具有延长释放活性药物成分的微胶囊材料及其制备方法 | |
| JPH0615163A (ja) | ファイバー入りゲルマイクロカプセル及びその製法 |