JPS60178863A - ピリジルエチルスルホン酸類の製造方法 - Google Patents
ピリジルエチルスルホン酸類の製造方法Info
- Publication number
- JPS60178863A JPS60178863A JP3490584A JP3490584A JPS60178863A JP S60178863 A JPS60178863 A JP S60178863A JP 3490584 A JP3490584 A JP 3490584A JP 3490584 A JP3490584 A JP 3490584A JP S60178863 A JPS60178863 A JP S60178863A
- Authority
- JP
- Japan
- Prior art keywords
- vinylpyridine
- sulfurous acid
- formula
- pyridylethylsulfonic
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title claims description 17
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 17
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 239000003960 organic solvent Substances 0.000 claims abstract description 6
- YQUDMNIUBTXLSX-UHFFFAOYSA-N 2-ethenyl-5-ethylpyridine Chemical compound CCC1=CC=C(C=C)N=C1 YQUDMNIUBTXLSX-UHFFFAOYSA-N 0.000 claims abstract description 4
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 claims description 32
- 239000007789 gas Substances 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 150000007513 acids Chemical class 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 6
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 claims description 4
- VMWGBWNAHAUQIO-UHFFFAOYSA-N 2-ethenyl-6-methylpyridine Chemical compound CC1=CC=CC(C=C)=N1 VMWGBWNAHAUQIO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 11
- 239000003905 agrochemical Substances 0.000 abstract description 2
- 238000007664 blowing Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 description 11
- 238000003756 stirring Methods 0.000 description 8
- -1 More specifically Chemical class 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000012046 mixed solvent Substances 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 230000020169 heat generation Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- QCVKCSGXBUKOKK-UHFFFAOYSA-M sodium;2-pyridin-2-ylethanesulfonate Chemical compound [Na+].[O-]S(=O)(=O)CCC1=CC=CC=N1 QCVKCSGXBUKOKK-UHFFFAOYSA-M 0.000 description 2
- MFGOIFRXBJVJLW-UHFFFAOYSA-N 2-(6-methylpyridin-2-yl)ethanesulfonic acid Chemical compound CC1=CC=CC(CCS(O)(=O)=O)=N1 MFGOIFRXBJVJLW-UHFFFAOYSA-N 0.000 description 1
- OAWPYKUOQNDAER-UHFFFAOYSA-N 2-ethylsulfonylpyridine Chemical compound CCS(=O)(=O)C1=CC=CC=N1 OAWPYKUOQNDAER-UHFFFAOYSA-N 0.000 description 1
- VRBVUAYEXFCDPE-UHFFFAOYSA-N 2-pyridin-2-ylethanesulfonic acid Chemical compound OS(=O)(=O)CCC1=CC=CC=N1 VRBVUAYEXFCDPE-UHFFFAOYSA-N 0.000 description 1
- RGIIAYDCZSXHGL-UHFFFAOYSA-N 2-pyridin-4-ylethanesulfonic acid Chemical compound OS(=O)(=O)CCC1=CC=NC=C1 RGIIAYDCZSXHGL-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 238000003916 acid precipitation Methods 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940079826 hydrogen sulfite Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Landscapes
- Pyridine Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3490584A JPS60178863A (ja) | 1984-02-24 | 1984-02-24 | ピリジルエチルスルホン酸類の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3490584A JPS60178863A (ja) | 1984-02-24 | 1984-02-24 | ピリジルエチルスルホン酸類の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60178863A true JPS60178863A (ja) | 1985-09-12 |
| JPH0479335B2 JPH0479335B2 (enrdf_load_stackoverflow) | 1992-12-15 |
Family
ID=12427200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3490584A Granted JPS60178863A (ja) | 1984-02-24 | 1984-02-24 | ピリジルエチルスルホン酸類の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60178863A (enrdf_load_stackoverflow) |
-
1984
- 1984-02-24 JP JP3490584A patent/JPS60178863A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0479335B2 (enrdf_load_stackoverflow) | 1992-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |