JPS6016933B2 - ２，６−ジメチル−３，５−ジメトキシカルボニル−４−（０−ジフルオロメトキシフエニル）−１，４−ジヒドロピリジン - Google Patents

２，６−ジメチル−３，５−ジメトキシカルボニル−４−（０−ジフルオロメトキシフエニル）−１，４−ジヒドロピリジン

Info

Publication number
JPS6016933B2
JPS6016933B2 JP54001047A JP104779A JPS6016933B2 JP S6016933 B2 JPS6016933 B2 JP S6016933B2 JP 54001047 A JP54001047 A JP 54001047A JP 104779 A JP104779 A JP 104779A JP S6016933 B2 JPS6016933 B2 JP S6016933B2
Authority
JP
Japan
Prior art keywords
dihydropyridine
dimethyl
dimethoxycarbonyl
difluoromethoxyphenyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54001047A
Other languages
English (en)
Japanese (ja)
Other versions
JPS54122280A (en
Inventor
バレリア・ヴアシリエブナ・カストロン
ラスマ・オスカロブナ・ヴイトリン
ユリ−・アルカデイエヴイチ・フイアルコフ
スヴエトラナ・ブラデイミロブナ・シエリアジエンコ
ギユナル・ヤノヴイチ・ドユブル
アグリス・アドルフオヴイチ・キメニス
レブ・モイセエヴイツチ・ヤグポルスキイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INSUCHI ORUGANICHESUKOI HIMII AN UKURAI SSR
INSUCHICHUUTO ORUGANIICHESUKAGO SHINTEEZA AKADEMII NAUKU RATOIISUKOI ESU ESU AARU
Original Assignee
INSUCHI ORUGANICHESUKOI HIMII AN UKURAI SSR
INSUCHICHUUTO ORUGANIICHESUKAGO SHINTEEZA AKADEMII NAUKU RATOIISUKOI ESU ESU AARU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INSUCHI ORUGANICHESUKOI HIMII AN UKURAI SSR, INSUCHICHUUTO ORUGANIICHESUKAGO SHINTEEZA AKADEMII NAUKU RATOIISUKOI ESU ESU AARU filed Critical INSUCHI ORUGANICHESUKOI HIMII AN UKURAI SSR
Publication of JPS54122280A publication Critical patent/JPS54122280A/ja
Publication of JPS6016933B2 publication Critical patent/JPS6016933B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP54001047A 1978-01-11 1979-01-11 ２，６−ジメチル−３，５−ジメトキシカルボニル−４−（０−ジフルオロメトキシフエニル）−１，４−ジヒドロピリジン Expired JPS6016933B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU782569286A SU706410A1 (ru) 1978-01-11 1978-01-11 2,6-Диметил-3,5-дикарбметокси-4(0-дифторметоксифенил)-1,4-дигидропиридин,обладающий выраженной гипотензивной активностью и оказывающий действие на функции вегетативной нервной системы

Publications (2)

Publication Number Publication Date
JPS54122280A JPS54122280A (en) 1979-09-21
JPS6016933B2 true JPS6016933B2 (ja) 1985-04-30

Family

ID=20744355

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54001047A Expired JPS6016933B2 (ja) 1978-01-11 1979-01-11 ２，６−ジメチル−３，５−ジメトキシカルボニル−４−（０−ジフルオロメトキシフエニル）−１，４−ジヒドロピリジン

Country Status (7)

Country Link
US (1) US4219653A (US06582424-20030624-M00016.png)
JP (1) JPS6016933B2 (US06582424-20030624-M00016.png)
CA (1) CA1117124A (US06582424-20030624-M00016.png)
DE (1) DE2900537A1 (US06582424-20030624-M00016.png)
FR (1) FR2414501A1 (US06582424-20030624-M00016.png)
GB (1) GB2013186B (US06582424-20030624-M00016.png)
SU (1) SU706410A1 (US06582424-20030624-M00016.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435574A (en) * 1981-07-20 1984-03-06 Kastron Valeria V 2,6-Dimethyl-3,5-dicarbomethoxy-4-(ortho-di-fluoromethylthiophenyl)-1,4-dihydropyridine
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
JPS58213712A (ja) * 1982-06-07 1983-12-12 Nikken Kagaku Kk Ｐｐ−１４６６含有持続性製剤
JPS59129279A (ja) * 1983-01-12 1984-07-25 Sekisui Chem Co Ltd ウレタン系粘着剤層の形成方法
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
EP0205511A1 (de) * 1984-12-21 1986-12-30 Byk Gulden Lomberg Chemische Fabrik GmbH Neue piperazinderivate
GB2180532B (en) * 1985-09-17 1989-08-23 Inst Organicheskogo Sinteza Ak Alkoxy-and phenoxy-alkyl-esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid
EP0289604A1 (de) * 1986-11-10 1988-11-09 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr 2-methylmercapto-3-cyano-4-(o-difluormethoxyphenyl)-6-phenyl-1,4-dihydropyridine
GB2221677A (en) * 1988-08-08 1990-02-14 Inst Organicheskogo Sinteza Ak 2,6-dimethyl-4-/2'-difluoromethoxyphenyl/-1,4-dihydropyridine-3,5-dicarboxylates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
US4021434A (en) * 1972-01-22 1977-05-03 Yamanouchi Pharmaceutical Co., Ltd. Sodium β-[2,6-dimethyl-3,5-bis(ethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-1-yl]ethyl sulfate
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives

Also Published As

Publication number Publication date
JPS54122280A (en) 1979-09-21
FR2414501A1 (fr) 1979-08-10
SU706410A1 (ru) 1979-12-30
GB2013186B (en) 1982-07-14
FR2414501B1 (US06582424-20030624-M00016.png) 1983-11-18
DE2900537C2 (US06582424-20030624-M00016.png) 1988-09-29
GB2013186A (en) 1979-08-08
DE2900537A1 (de) 1979-07-12
CA1117124A (en) 1982-01-26
US4219653A (en) 1980-08-26

Similar Documents

Publication Publication Date Title
NO895281D0 (no) Nye piperazinylderivater.
DE2462086A1 (de) 4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DK92781A (da) Fremgangsmaade til fremstilling af indanderivater eller syreadditionssalte deraf
JPS6016933B2 (ja) ２，６−ジメチル−３，５−ジメトキシカルボニル−４−（０−ジフルオロメトキシフエニル）−１，４−ジヒドロピリジン
US3696112A (en) Sulphur-containing 1,4-dihydropyridine derivatives
DE69131359D1 (de) Kondensierte Thiazolverbindungen, ihre Darstellung und ihre Anwendung
WO2002034754A3 (en) Benzoxazinone derivatives, their preparation and use
US4123530A (en) N-cyclohexyl-piperazino acetamides and propionamides
CA1038380A (fr) (oxymethylene-2,6) morpholino (4,3a) benzimidazoles, leur procede de preparation et leur application en therapeutique
PT1080081E (pt) Derivados do benzofuraxano e a sua utilizacao no tratamento da angina de peito
KR880001477B1 (ko) 니플룸산 모르폴리노에틸에스테르 디니플루메이트의 제조방법
JPS6013789A (ja) １，４−ジヒドロピリジン誘導体、その製造および医薬
JPS62281860A (ja) アルキレンアミノアルキレン　ヘテロ原子基を有するジヒドロ−３，５−ジカルボキシレ−ト
US3840539A (en) Phthalazine derivatives
US4435574A (en) 2,6-Dimethyl-3,5-dicarbomethoxy-4-(ortho-di-fluoromethylthiophenyl)-1,4-dihydropyridine
DE2531829A1 (de) N-(3,4,5-trimethoxycinnamoyl)-n'- (2'-pyrrolidinon-1'-carbonylmethyl) -piperazin, verfahren zu dessen herstellung und diese verbindung enthaltende arzneipraeparate
DE2844595A1 (de) Acylaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3515787A (en) Compositions and methods for producing a muscle relaxing effect in an animal with 2,3 - substituted - 6 - amino-4-quinazolones
EP0442348B1 (de) Neue Imidazolverbindungen, Verfahren zu deren Herstellung, Arzneimittel auf Basis dieser Verbindungen sowie einige Zwischenprodukte
JPS61122288A (ja) チエノピリジン誘導体、その製造法及びそれを含有する医薬組成物
US3420839A (en) Aminomethyl pyrazolone derivatives of nicotinamide
JPS59170094A (ja) 置換された４，１０−ジヒドロ−１０−オキソチエノ−ベンズオキセピン類およびその製法
DE2935062A1 (de) Substituierte aminoalkylguanidine, deren herstellung und arzneimittel
JPS6026785B2 (ja) 新規イリキノリン誘導体の製法
JPS6022714B2 (ja) キナゾリン誘導体及びその製造法