JPS60123426A - 経鼻投与用セクレチン製剤 - Google Patents
経鼻投与用セクレチン製剤Info
- Publication number
- JPS60123426A JPS60123426A JP58229820A JP22982083A JPS60123426A JP S60123426 A JPS60123426 A JP S60123426A JP 58229820 A JP58229820 A JP 58229820A JP 22982083 A JP22982083 A JP 22982083A JP S60123426 A JPS60123426 A JP S60123426A
- Authority
- JP
- Japan
- Prior art keywords
- secretin
- osmotic pressure
- aqueous solution
- preparation
- pressure ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100037505 Secretin Human genes 0.000 title claims abstract description 36
- 108010086019 Secretin Proteins 0.000 title claims abstract description 36
- 229960002101 secretin Drugs 0.000 title claims abstract description 36
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000007864 aqueous solution Substances 0.000 claims abstract description 18
- 230000003204 osmotic effect Effects 0.000 claims abstract description 17
- 239000000243 solution Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract description 14
- 230000028327 secretion Effects 0.000 abstract description 8
- 239000011780 sodium chloride Substances 0.000 abstract description 7
- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 abstract description 5
- 230000001186 cumulative effect Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 210000000232 gallbladder Anatomy 0.000 abstract description 2
- 210000000496 pancreas Anatomy 0.000 abstract 2
- 238000013329 compounding Methods 0.000 abstract 1
- 239000008055 phosphate buffer solution Substances 0.000 abstract 1
- 210000002850 nasal mucosa Anatomy 0.000 description 5
- 238000009472 formulation Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- 241000700159 Rattus Species 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 210000000277 pancreatic duct Anatomy 0.000 description 2
- 210000001819 pancreatic juice Anatomy 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003629 gastrointestinal hormone Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58229820A JPS60123426A (ja) | 1983-12-07 | 1983-12-07 | 経鼻投与用セクレチン製剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58229820A JPS60123426A (ja) | 1983-12-07 | 1983-12-07 | 経鼻投与用セクレチン製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60123426A true JPS60123426A (ja) | 1985-07-02 |
| JPH0376291B2 JPH0376291B2 (enExample) | 1991-12-05 |
Family
ID=16898174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58229820A Granted JPS60123426A (ja) | 1983-12-07 | 1983-12-07 | 経鼻投与用セクレチン製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60123426A (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG64919B1 (bg) * | 1998-04-21 | 2006-09-29 | Teijin Ltd. | Фармацевтичен състав за прилагане върху мукоза |
| JP2007532515A (ja) * | 2004-04-07 | 2007-11-15 | アレス トレーディング ソシエテ アノニム | 成長ホルモン液剤 |
| KR20180066071A (ko) | 2015-10-30 | 2018-06-18 | 데이진 화-마 가부시키가이샤 | 비점막 투여용 의약 조성물 |
-
1983
- 1983-12-07 JP JP58229820A patent/JPS60123426A/ja active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG64919B1 (bg) * | 1998-04-21 | 2006-09-29 | Teijin Ltd. | Фармацевтичен състав за прилагане върху мукоза |
| JP2007532515A (ja) * | 2004-04-07 | 2007-11-15 | アレス トレーディング ソシエテ アノニム | 成長ホルモン液剤 |
| KR20180066071A (ko) | 2015-10-30 | 2018-06-18 | 데이진 화-마 가부시키가이샤 | 비점막 투여용 의약 조성물 |
| US10849978B2 (en) | 2015-10-30 | 2020-12-01 | Teijin Pharma Limited | Pharmaceutical composition for administration to nasal mucosa |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0376291B2 (enExample) | 1991-12-05 |
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