JPH0376291B2 - - Google Patents

Info

Publication number

JPH0376291B2

JPH0376291B2 JP58229820A JP22982083A JPH0376291B2 JP H0376291 B2 JPH0376291 B2 JP H0376291B2 JP 58229820 A JP58229820 A JP 58229820A JP 22982083 A JP22982083 A JP 22982083A JP H0376291 B2 JPH0376291 B2 JP H0376291B2

Authority

JP

Japan

Prior art keywords

secretin

aqueous solution

present

osmotic pressure

nasal

Prior art date

1983-12-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

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• Global Dossier
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• 102100037505 Secretin Human genes 0.000 claims description 29
• 108010086019 Secretin Proteins 0.000 claims description 29
• 229960002101 secretin Drugs 0.000 claims description 29
• OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 claims description 29
• 239000007864 aqueous solution Substances 0.000 claims description 16
• 230000003204 osmotic effect Effects 0.000 claims description 13
• 238000002360 preparation method Methods 0.000 claims description 11
• 239000000243 solution Substances 0.000 claims description 5
• 239000000843 powder Substances 0.000 claims description 3
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
• 210000002850 nasal mucosa Anatomy 0.000 description 6
• 239000008363 phosphate buffer Substances 0.000 description 6
• 230000028327 secretion Effects 0.000 description 6
• 239000011780 sodium chloride Substances 0.000 description 6
• GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 4
• 238000009472 formulation Methods 0.000 description 4
• 238000000034 method Methods 0.000 description 4
• 239000000203 mixture Substances 0.000 description 4
• 241000700159 Rattus Species 0.000 description 2
• 239000000872 buffer Substances 0.000 description 2
• 238000004090 dissolution Methods 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 239000007924 injection Substances 0.000 description 2
• 238000002347 injection Methods 0.000 description 2
• 210000000277 pancreatic duct Anatomy 0.000 description 2
• 210000001819 pancreatic juice Anatomy 0.000 description 2
• 238000005507 spraying Methods 0.000 description 2
• 102000004190 Enzymes Human genes 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• 239000003708 ampul Substances 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 239000012043 crude product Substances 0.000 description 1
• 230000001186 cumulative effect Effects 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 238000000855 fermentation Methods 0.000 description 1
• 230000004151 fermentation Effects 0.000 description 1
• 210000000232 gallbladder Anatomy 0.000 description 1
• 239000003629 gastrointestinal hormone Substances 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 230000003301 hydrolyzing effect Effects 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 239000007928 intraperitoneal injection Substances 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• -1 polyethylene Polymers 0.000 description 1
• 229920000573 polyethylene Polymers 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 239000012264 purified product Substances 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1