JPS5982367A - ６−置換キノリン−５，８−キノン類 - Google Patents

６−置換キノリン−５，８−キノン類

Info

Publication number
JPS5982367A
JPS5982367A JP58182917A JP18291783A JPS5982367A JP S5982367 A JPS5982367 A JP S5982367A JP 58182917 A JP58182917 A JP 58182917A JP 18291783 A JP18291783 A JP 18291783A JP S5982367 A JPS5982367 A JP S5982367A
Authority
JP
Japan
Prior art keywords
alkyl
hydrogen
formula
quinone
excluding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP58182917A
Other languages
English (en)
Japanese (ja)
Inventor
ジエロ−ム・エイチ・フレイシユ
ウインストン・エス・マ−シヤル
ジヨ−ジ・ジエイ・キユリナン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS5982367A publication Critical patent/JPS5982367A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP58182917A 1982-09-30 1983-09-29 ６−置換キノリン−５，８−キノン類 Pending JPS5982367A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/430,895 US4492704A (en) 1982-09-30 1982-09-30 Quinoline quinones and anti-asthmatic use thereof
US430895 1982-09-30

Publications (1)

Publication Number Publication Date
JPS5982367A true JPS5982367A (ja) 1984-05-12

Family

ID=23709535

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58182917A Pending JPS5982367A (ja) 1982-09-30 1983-09-29 ６−置換キノリン−５，８−キノン類

Country Status (10)

Country Link
US (1) US4492704A (enExample)
EP (1) EP0107367B1 (enExample)
JP (1) JPS5982367A (enExample)
KR (1) KR840006207A (enExample)
CA (1) CA1211110A (enExample)
DE (1) DE3380304D1 (enExample)
DK (1) DK446483A (enExample)
GB (1) GB2127814A (enExample)
GR (1) GR78721B (enExample)
IL (1) IL69818A0 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576949A (en) * 1984-05-07 1986-03-18 The Upjohn Company Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein
CA1285951C (en) * 1985-10-28 1991-07-09 Raj N. Misra Naphthalenyl- and quinolinyl-amino substituted phenols
US4692449A (en) * 1986-06-20 1987-09-08 American Cyanamid Company Substituted quinolinediones
US4963565A (en) * 1986-07-30 1990-10-16 National Jewish Center For Immunology And Respiratory Medicine In vivo treatment of mycobacterial infections with 6-cyclo octylamino-5,8-quinoline quinone
US5120843A (en) * 1987-04-27 1992-06-09 Upjohn Pharmaceutically active amines
KR20030038282A (ko) * 2001-11-06 2003-05-16 주식회사 켐온 6-아닐리노퀴놀린-5,8-퀴논을 유효성분으로 함유하는혈관생성 억제제
EP1398031A1 (en) * 2002-09-06 2004-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 6-amino-quinoline-5,8-quinones and nucleic acids associated with senescence for the treatment of tumors
AU2003230309A1 (en) * 2003-05-06 2004-11-26 Chemon Inc. As a pkc inhibitor, inhibitor for angiogenesis containing 6-anilinoquinoline-5,8-quinone as an effective ingredient
WO2010042500A2 (en) * 2008-10-06 2010-04-15 Emory University Heat shock protein 90 inhibitors, methods of preparing same, and methods for their use
RU2018135141A (ru) 2016-03-08 2020-04-08 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Низкомолекулярные индукторы активных форм кислорода и ингибиторы митохондриальной активности
US10550135B2 (en) 2016-03-30 2020-02-04 Council Of Scientific & Industrial Research Silicon incorporated quinolines with anti-malarial and anti-toxoplasmosis activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002310B1 (en) * 1977-11-10 1981-06-24 Beecham Group Plc 4,9-dihydro-4,9-dioxo-1h-naphtho(2,3-d) triazoles, their preparation and antiallergic compositions containing them

Also Published As

Publication number Publication date
EP0107367B1 (en) 1989-08-02
EP0107367A2 (en) 1984-05-02
EP0107367A3 (en) 1985-05-15
DE3380304D1 (en) 1989-09-07
KR840006207A (ko) 1984-11-22
US4492704A (en) 1985-01-08
DK446483A (da) 1984-03-31
CA1211110A (en) 1986-09-09
GB2127814A (en) 1984-04-18
IL69818A0 (en) 1983-12-30
DK446483D0 (da) 1983-09-29
GB8325678D0 (en) 1983-10-26
GR78721B (enExample) 1984-10-02

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