KR840006207A - 6-치환된-퀴놀린-5,6-퀴논의 제조방법 - Google Patents
6-치환된-퀴놀린-5,6-퀴논의 제조방법 Download PDFInfo
- Publication number
- KR840006207A KR840006207A KR1019830004605A KR830004605A KR840006207A KR 840006207 A KR840006207 A KR 840006207A KR 1019830004605 A KR1019830004605 A KR 1019830004605A KR 830004605 A KR830004605 A KR 830004605A KR 840006207 A KR840006207 A KR 840006207A
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogen
- alkyl
- compound
- preparing
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims 2
- 239000001257 hydrogen Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- NTHDUEPLVVPGEX-UHFFFAOYSA-N 6-(3-fluoroanilino)quinoline-5,8-dione Chemical compound FC1=CC=CC(NC=2C(C3=CC=CN=C3C(=O)C=2)=O)=C1 NTHDUEPLVVPGEX-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- -1 P-tolyl Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- MXOAEAUPQDYUQM-UHFFFAOYSA-N chlorphenesin Chemical group OCC(O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-UHFFFAOYSA-N 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US430895 | 1982-09-30 | ||
| US06/430,895 US4492704A (en) | 1982-09-30 | 1982-09-30 | Quinoline quinones and anti-asthmatic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840006207A true KR840006207A (ko) | 1984-11-22 |
Family
ID=23709535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830004605A Ceased KR840006207A (ko) | 1982-09-30 | 1983-09-29 | 6-치환된-퀴놀린-5,6-퀴논의 제조방법 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4492704A (enExample) |
| EP (1) | EP0107367B1 (enExample) |
| JP (1) | JPS5982367A (enExample) |
| KR (1) | KR840006207A (enExample) |
| CA (1) | CA1211110A (enExample) |
| DE (1) | DE3380304D1 (enExample) |
| DK (1) | DK446483A (enExample) |
| GB (1) | GB2127814A (enExample) |
| GR (1) | GR78721B (enExample) |
| IL (1) | IL69818A0 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4576949A (en) * | 1984-05-07 | 1986-03-18 | The Upjohn Company | Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein |
| CA1285951C (en) * | 1985-10-28 | 1991-07-09 | Raj N. Misra | Naphthalenyl- and quinolinyl-amino substituted phenols |
| US4692449A (en) * | 1986-06-20 | 1987-09-08 | American Cyanamid Company | Substituted quinolinediones |
| US4963565A (en) * | 1986-07-30 | 1990-10-16 | National Jewish Center For Immunology And Respiratory Medicine | In vivo treatment of mycobacterial infections with 6-cyclo octylamino-5,8-quinoline quinone |
| US5120843A (en) * | 1987-04-27 | 1992-06-09 | Upjohn | Pharmaceutically active amines |
| KR20030038282A (ko) * | 2001-11-06 | 2003-05-16 | 주식회사 켐온 | 6-아닐리노퀴놀린-5,8-퀴논을 유효성분으로 함유하는혈관생성 억제제 |
| EP1398031A1 (en) * | 2002-09-06 | 2004-03-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of 6-amino-quinoline-5,8-quinones and nucleic acids associated with senescence for the treatment of tumors |
| AU2003230309A1 (en) * | 2003-05-06 | 2004-11-26 | Chemon Inc. | As a pkc inhibitor, inhibitor for angiogenesis containing 6-anilinoquinoline-5,8-quinone as an effective ingredient |
| WO2010042500A2 (en) * | 2008-10-06 | 2010-04-15 | Emory University | Heat shock protein 90 inhibitors, methods of preparing same, and methods for their use |
| US10781183B2 (en) | 2016-03-08 | 2020-09-22 | The Regents Of The University Of Michigan | Small molecule inducers of reactive oxygen species and inhibitors of mitochondrial activity |
| WO2017168448A1 (en) | 2016-03-30 | 2017-10-05 | Council Of Scientific & Industrial Research | Silicon incorporated quinolines with anti-malarial and anti-toxoplasmosis activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002310B1 (en) * | 1977-11-10 | 1981-06-24 | Beecham Group Plc | 4,9-dihydro-4,9-dioxo-1h-naphtho(2,3-d) triazoles, their preparation and antiallergic compositions containing them |
-
1982
- 1982-09-30 US US06/430,895 patent/US4492704A/en not_active Expired - Lifetime
-
1983
- 1983-09-26 EP EP83305740A patent/EP0107367B1/en not_active Expired
- 1983-09-26 IL IL69818A patent/IL69818A0/xx unknown
- 1983-09-26 DE DE8383305740T patent/DE3380304D1/de not_active Expired
- 1983-09-26 GB GB08325678A patent/GB2127814A/en not_active Withdrawn
- 1983-09-27 GR GR72552A patent/GR78721B/el unknown
- 1983-09-27 CA CA000437667A patent/CA1211110A/en not_active Expired
- 1983-09-29 DK DK446483A patent/DK446483A/da not_active Application Discontinuation
- 1983-09-29 JP JP58182917A patent/JPS5982367A/ja active Pending
- 1983-09-29 KR KR1019830004605A patent/KR840006207A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE3380304D1 (en) | 1989-09-07 |
| GB2127814A (en) | 1984-04-18 |
| IL69818A0 (en) | 1983-12-30 |
| EP0107367A3 (en) | 1985-05-15 |
| EP0107367B1 (en) | 1989-08-02 |
| US4492704A (en) | 1985-01-08 |
| JPS5982367A (ja) | 1984-05-12 |
| GB8325678D0 (en) | 1983-10-26 |
| GR78721B (enExample) | 1984-10-02 |
| EP0107367A2 (en) | 1984-05-02 |
| CA1211110A (en) | 1986-09-09 |
| DK446483D0 (da) | 1983-09-29 |
| DK446483A (da) | 1984-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19830929 |
|
| PG1501 | Laying open of application | ||
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19860614 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19860829 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19860614 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |