DE3380304D1 - 6-substituted-quinoline-5,8-quinones - Google Patents

6-substituted-quinoline-5,8-quinones

Info

Publication number
DE3380304D1
DE3380304D1 DE8383305740T DE3380304T DE3380304D1 DE 3380304 D1 DE3380304 D1 DE 3380304D1 DE 8383305740 T DE8383305740 T DE 8383305740T DE 3380304 T DE3380304 T DE 3380304T DE 3380304 D1 DE3380304 D1 DE 3380304D1
Authority
DE
Germany
Prior art keywords
quinones
quinoline
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383305740T
Other languages
English (en)
Inventor
Jerome Herbert Fleisch
Winston Stanley Marshall
George Joseph Cullinan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3380304D1 publication Critical patent/DE3380304D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8383305740T 1982-09-30 1983-09-26 6-substituted-quinoline-5,8-quinones Expired DE3380304D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/430,895 US4492704A (en) 1982-09-30 1982-09-30 Quinoline quinones and anti-asthmatic use thereof

Publications (1)

Publication Number Publication Date
DE3380304D1 true DE3380304D1 (en) 1989-09-07

Family

ID=23709535

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383305740T Expired DE3380304D1 (en) 1982-09-30 1983-09-26 6-substituted-quinoline-5,8-quinones

Country Status (10)

Country Link
US (1) US4492704A (de)
EP (1) EP0107367B1 (de)
JP (1) JPS5982367A (de)
KR (1) KR840006207A (de)
CA (1) CA1211110A (de)
DE (1) DE3380304D1 (de)
DK (1) DK446483A (de)
GB (1) GB2127814A (de)
GR (1) GR78721B (de)
IL (1) IL69818A0 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576949A (en) * 1984-05-07 1986-03-18 The Upjohn Company Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein
CA1285951C (en) * 1985-10-28 1991-07-09 Raj N. Misra Naphthalenyl- and quinolinyl-amino substituted phenols
US4692449A (en) * 1986-06-20 1987-09-08 American Cyanamid Company Substituted quinolinediones
US4963565A (en) * 1986-07-30 1990-10-16 National Jewish Center For Immunology And Respiratory Medicine In vivo treatment of mycobacterial infections with 6-cyclo octylamino-5,8-quinoline quinone
US5120843A (en) * 1987-04-27 1992-06-09 Upjohn Pharmaceutically active amines
KR20030038282A (ko) * 2001-11-06 2003-05-16 주식회사 켐온 6-아닐리노퀴놀린-5,8-퀴논을 유효성분으로 함유하는혈관생성 억제제
EP1398031A1 (de) * 2002-09-06 2004-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von 6-Amino-Chinolin-5,8-chinonen und Seneszent-assoziierten Nukleinsäuren zur Behandlung von Tumoren
AU2003230309A1 (en) * 2003-05-06 2004-11-26 Chemon Inc. As a pkc inhibitor, inhibitor for angiogenesis containing 6-anilinoquinoline-5,8-quinone as an effective ingredient
WO2010042500A2 (en) * 2008-10-06 2010-04-15 Emory University Heat shock protein 90 inhibitors, methods of preparing same, and methods for their use
WO2017155991A1 (en) * 2016-03-08 2017-09-14 The Regents Of The University Of Michigan Small molecule inducers of reactive oxygen species and inhibitors of mitochondrial activity
WO2017168448A1 (en) 2016-03-30 2017-10-05 Council Of Scientific & Industrial Research Silicon incorporated quinolines with anti-malarial and anti-toxoplasmosis activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002310B1 (de) * 1977-11-10 1981-06-24 Beecham Group Plc 4,9-Dihydro-4,9-dioxo-1H-naphtho(2,3-d) triazole, ihre Herstellung und sie enthaltende antiallergische Zusammensetzungen

Also Published As

Publication number Publication date
IL69818A0 (en) 1983-12-30
JPS5982367A (ja) 1984-05-12
KR840006207A (ko) 1984-11-22
US4492704A (en) 1985-01-08
DK446483D0 (da) 1983-09-29
CA1211110A (en) 1986-09-09
EP0107367B1 (de) 1989-08-02
GR78721B (de) 1984-10-02
GB8325678D0 (en) 1983-10-26
EP0107367A3 (en) 1985-05-15
GB2127814A (en) 1984-04-18
EP0107367A2 (de) 1984-05-02
DK446483A (da) 1984-03-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee