JPS5939415B2 - 〔1−オキソ−2−アリ−ルまたはチエニル−2−置換−5−インダニルオキシ(またはチオ)〕アルカン酸の製法 - Google Patents

〔1−オキソ−2−アリ−ルまたはチエニル−2−置換−5−インダニルオキシ(またはチオ)〕アルカン酸の製法

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Publication number
JPS5939415B2
JPS5939415B2 JP49116987A JP11698774A JPS5939415B2 JP S5939415 B2 JPS5939415 B2 JP S5939415B2 JP 49116987 A JP49116987 A JP 49116987A JP 11698774 A JP11698774 A JP 11698774A JP S5939415 B2 JPS5939415 B2 JP S5939415B2
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Japan
Prior art keywords
dichloro
methyl
lower alkyl
formula
mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP49116987A
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English (en)
Japanese (ja)
Other versions
JPS5076058A (cs
Inventor
ジエ− クラゴ− ジユニヤ エドワ−ド
ダブリユ ウオルタ−スドルフ ジユニヤ オツト−
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Merck and Co Inc
Original Assignee
Merck and Co Inc
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Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS5076058A publication Critical patent/JPS5076058A/ja
Publication of JPS5939415B2 publication Critical patent/JPS5939415B2/ja
Expired legal-status Critical Current

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33Polycyclic acids
    • C07C63/337Polycyclic acids with carboxyl groups bound to condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
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    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C255/00Carboxylic acid nitriles
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    • C07C255/13Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
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    • C07C45/63Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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    • C07C45/65Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
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    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
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    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/487Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
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    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
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    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D475/00Heterocyclic compounds containing pteridine ring systems
    • C07D475/06Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
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    • C07C2602/00Systems containing two condensed rings
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    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP49116987A 1973-10-11 1974-10-11 〔1−オキソ−2−アリ−ルまたはチエニル−2−置換−5−インダニルオキシ(またはチオ)〕アルカン酸の製法 Expired JPS5939415B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40573673A 1973-10-11 1973-10-11
US405736 1973-10-11
US49265174A 1974-07-30 1974-07-30
US492651 1974-07-30

Publications (2)

Publication Number Publication Date
JPS5076058A JPS5076058A (cs) 1975-06-21
JPS5939415B2 true JPS5939415B2 (ja) 1984-09-22

Family

ID=27019215

Family Applications (1)

Application Number Title Priority Date Filing Date
JP49116987A Expired JPS5939415B2 (ja) 1973-10-11 1974-10-11 〔1−オキソ−2−アリ−ルまたはチエニル−2−置換−5−インダニルオキシ(またはチオ)〕アルカン酸の製法

Country Status (27)

Country Link
JP (1) JPS5939415B2 (cs)
KR (1) KR870000034B1 (cs)
AR (4) AR213065A1 (cs)
AT (1) AT342036B (cs)
BG (1) BG28255A3 (cs)
CA (1) CA1063125A (cs)
CH (2) CH610290A5 (cs)
CS (1) CS190439B2 (cs)
CY (1) CY1074A (cs)
DD (1) DD118075A5 (cs)
DE (2) DE2463215C2 (cs)
EG (1) EG11741A (cs)
ES (2) ES430900A1 (cs)
FR (1) FR2247218B1 (cs)
GB (2) GB1474460A (cs)
HK (1) HK47680A (cs)
HU (1) HU169587B (cs)
IE (1) IE39927B1 (cs)
IL (1) IL45779A (cs)
KE (1) KE3068A (cs)
LU (1) LU71078A1 (cs)
MY (1) MY8100163A (cs)
NL (2) NL187854C (cs)
PH (2) PH22225A (cs)
RO (2) RO64568A (cs)
SU (1) SU738509A3 (cs)
YU (1) YU39727B (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111004107A (zh) * 2019-01-14 2020-04-14 山东大学 含丙烯酮的取代二氯苯化合物及制备方法与应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51535B1 (en) * 1980-09-02 1987-01-07 Merck & Co Inc Pharmaceutical compositions containing 4-((6,7-dihalogen-2,3-dihydro-1-oxo-1h-inden-5-yl)-oxy)butanoic acid compounds
US5489712A (en) * 1994-11-04 1996-02-06 Hoechst Celanese Corporation Process for preparing cyclic ketones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3668241A (en) * 1968-11-25 1972-06-06 Merck & Co Inc Substituted 1-oxoinden-5-yloxy alkanoic acids
US3704314A (en) * 1968-11-25 1972-11-28 Merck & Co Inc (1-oxo-2-alkylideneindanyloxy) and (1-oxo - 2 - alkylideneindanylthio) alkanoic acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111004107A (zh) * 2019-01-14 2020-04-14 山东大学 含丙烯酮的取代二氯苯化合物及制备方法与应用

Also Published As

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SU738509A3 (ru) 1980-05-30
ATA807874A (de) 1977-07-15
CS190439B2 (en) 1979-05-31
KR870000034B1 (ko) 1987-02-07
IE39927L (en) 1975-04-11
NL9100396A (nl) 1991-06-03
YU39727B (en) 1985-04-30
AR213840A1 (es) 1979-03-30
CH610290A5 (en) 1979-04-12
RO71480B (ro) 1983-07-30
FR2247218B1 (cs) 1978-02-03
CH613933A5 (en) 1979-10-31
YU272774A (en) 1983-06-30
GB1474460A (en) 1977-05-25
KR830000198A (ko) 1983-03-30
ES449917A1 (es) 1977-11-16
DD118075A5 (cs) 1976-02-12
EG11741A (en) 1977-12-31
ES430900A1 (es) 1977-01-01
FR2247218A1 (cs) 1975-05-09
AR213065A1 (es) 1978-12-15
RO71480A (ro) 1983-08-03
JPS5076058A (cs) 1975-06-21
NL187854B (nl) 1991-09-02
KE3068A (en) 1980-08-08
AT342036B (de) 1978-03-10
AU7391674A (en) 1976-04-08
AR213620A1 (es) 1979-02-28
BG28255A3 (en) 1980-03-25
DE2448454C2 (de) 1985-08-29
RO64568A (fr) 1979-03-15
AR213170A1 (es) 1978-12-29
HU169587B (cs) 1976-12-28
DE2448454A1 (de) 1975-04-24
CY1074A (en) 1980-10-24
CA1063125A (en) 1979-09-25
PH22017A (en) 1988-05-13
LU71078A1 (cs) 1975-06-24
DE2463215C2 (de) 1986-03-13
MY8100163A (en) 1981-12-31
IL45779A (en) 1978-06-15
IE39927B1 (en) 1979-01-31
IL45779A0 (en) 1974-12-31
GB1474459A (en) 1977-05-25
NL7412829A (nl) 1975-04-15
HK47680A (en) 1980-09-05
NL187854C (nl) 1992-02-03
PH22225A (en) 1988-07-01

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