JPS59216830A - 放射性物質を含む化合物の小型自動合成装置 - Google Patents
放射性物質を含む化合物の小型自動合成装置Info
- Publication number
- JPS59216830A JPS59216830A JP9325083A JP9325083A JPS59216830A JP S59216830 A JPS59216830 A JP S59216830A JP 9325083 A JP9325083 A JP 9325083A JP 9325083 A JP9325083 A JP 9325083A JP S59216830 A JPS59216830 A JP S59216830A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- synthesis
- valve
- flask
- line
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 50
- 238000003786 synthesis reaction Methods 0.000 title claims description 112
- 230000015572 biosynthetic process Effects 0.000 title claims description 96
- 239000000941 radioactive substance Substances 0.000 title claims description 9
- 238000006243 chemical reaction Methods 0.000 claims abstract description 117
- 239000002994 raw material Substances 0.000 claims abstract description 45
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 238000004811 liquid chromatography Methods 0.000 claims abstract description 5
- 238000000605 extraction Methods 0.000 claims description 12
- 230000005855 radiation Effects 0.000 claims description 9
- 230000002194 synthesizing effect Effects 0.000 claims description 5
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 230000001133 acceleration Effects 0.000 claims description 2
- 239000000047 product Substances 0.000 abstract description 60
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 41
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 29
- 230000002285 radioactive effect Effects 0.000 abstract description 23
- 238000010438 heat treatment Methods 0.000 abstract description 21
- 238000000034 method Methods 0.000 abstract description 16
- 230000008569 process Effects 0.000 abstract description 14
- 238000001816 cooling Methods 0.000 abstract description 8
- 229910001873 dinitrogen Inorganic materials 0.000 abstract description 5
- 239000007795 chemical reaction product Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 48
- 238000004128 high performance liquid chromatography Methods 0.000 description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
- 229960004452 methionine Drugs 0.000 description 28
- 239000000243 solution Substances 0.000 description 27
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 26
- 238000002347 injection Methods 0.000 description 26
- 239000007924 injection Substances 0.000 description 26
- 229930182817 methionine Natural products 0.000 description 26
- 239000011541 reaction mixture Substances 0.000 description 25
- 239000007789 gas Substances 0.000 description 22
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- 239000002904 solvent Substances 0.000 description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 19
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 16
- 229910052757 nitrogen Inorganic materials 0.000 description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 13
- 238000002955 isolation Methods 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 11
- 238000004140 cleaning Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 238000010586 diagram Methods 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 238000012546 transfer Methods 0.000 description 10
- 238000001035 drying Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 9
- 238000009206 nuclear medicine Methods 0.000 description 9
- 238000000746 purification Methods 0.000 description 9
- 238000005406 washing Methods 0.000 description 9
- 238000003908 quality control method Methods 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 239000002826 coolant Substances 0.000 description 7
- 238000004587 chromatography analysis Methods 0.000 description 6
- 238000003780 insertion Methods 0.000 description 6
- 230000037431 insertion Effects 0.000 description 6
- 239000004809 Teflon Substances 0.000 description 5
- 229920006362 Teflon® Polymers 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000002131 composite material Substances 0.000 description 5
- 239000012217 radiopharmaceutical Substances 0.000 description 5
- 229940121896 radiopharmaceutical Drugs 0.000 description 5
- 230000002799 radiopharmaceutical effect Effects 0.000 description 5
- 239000003507 refrigerant Substances 0.000 description 5
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 5
- OROGUZVNAFJPHA-UHFFFAOYSA-N 3-hydroxy-2,4-dimethyl-2H-thiophen-5-one Chemical compound CC1SC(=O)C(C)=C1O OROGUZVNAFJPHA-UHFFFAOYSA-N 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- ZTVZLYBCZNMWCF-UHFFFAOYSA-N homocystine Chemical compound [O-]C(=O)C([NH3+])CCSSCCC([NH3+])C([O-])=O ZTVZLYBCZNMWCF-UHFFFAOYSA-N 0.000 description 4
- 238000007069 methylation reaction Methods 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- -1 methyl halides Chemical class 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000001308 synthesis method Methods 0.000 description 3
- ZTVZLYBCZNMWCF-WDSKDSINSA-N L,L-homocystine zwitterion Chemical compound OC(=O)[C@@H](N)CCSSCC[C@H](N)C(O)=O ZTVZLYBCZNMWCF-WDSKDSINSA-N 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000036267 drug metabolism Effects 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000002600 positron emission tomography Methods 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- FFEARJCKVFRZRR-FXLFCPKBSA-N (2s)-2-azanyl-4-methylsulfanyl-butanoic acid Chemical compound CSCC[14C@H](N)C(O)=O FFEARJCKVFRZRR-FXLFCPKBSA-N 0.000 description 1
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- 229930195722 L-methionine Natural products 0.000 description 1
- 101150086759 MAP3K1 gene Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000680714 Rhodine Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 229910052770 Uranium Inorganic materials 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical compound [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005112 continuous flow technique Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- FFEARJCKVFRZRR-JJZBXVGDSA-N methionine c-11 Chemical compound [11CH3]SCC[C@H](N)C(O)=O FFEARJCKVFRZRR-JJZBXVGDSA-N 0.000 description 1
- 150000002741 methionine derivatives Chemical class 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 238000001323 two-dimensional chromatography Methods 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9325083A JPS59216830A (ja) | 1983-05-25 | 1983-05-25 | 放射性物質を含む化合物の小型自動合成装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9325083A JPS59216830A (ja) | 1983-05-25 | 1983-05-25 | 放射性物質を含む化合物の小型自動合成装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59216830A true JPS59216830A (ja) | 1984-12-06 |
| JPH0416446B2 JPH0416446B2 (enExample) | 1992-03-24 |
Family
ID=14077255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9325083A Granted JPS59216830A (ja) | 1983-05-25 | 1983-05-25 | 放射性物質を含む化合物の小型自動合成装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59216830A (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61245837A (ja) * | 1985-04-25 | 1986-11-01 | Sumitomo Heavy Ind Ltd | ミクロ反応及び分取装置 |
| JPH01249135A (ja) * | 1988-03-31 | 1989-10-04 | Takeda Chem Ind Ltd | 自動合成装置 |
| JPH022870A (ja) * | 1988-03-11 | 1990-01-08 | Takeda Chem Ind Ltd | 自動合成装置 |
| JPH06312009A (ja) * | 1993-04-28 | 1994-11-08 | Daiichi Rajio Isotope Kenkyusho:Kk | 放射性医薬品加熱装置 |
| JP2004136228A (ja) * | 2002-10-18 | 2004-05-13 | Chemgenesis Inc | 液相系自動有機合成装置 |
| JP2010260799A (ja) * | 2009-04-30 | 2010-11-18 | Jfe Engineering Corp | マイクロチップを用いたｐｅｔ用標識化合物の製造方法及び装置 |
| JP2014012684A (ja) * | 2002-03-15 | 2014-01-23 | Hammersmith Imanet Ltd | 微細加工デバイスの使用 |
-
1983
- 1983-05-25 JP JP9325083A patent/JPS59216830A/ja active Granted
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61245837A (ja) * | 1985-04-25 | 1986-11-01 | Sumitomo Heavy Ind Ltd | ミクロ反応及び分取装置 |
| JPH022870A (ja) * | 1988-03-11 | 1990-01-08 | Takeda Chem Ind Ltd | 自動合成装置 |
| US5164159A (en) * | 1988-03-11 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Automated synthesizing apparatus |
| JPH01249135A (ja) * | 1988-03-31 | 1989-10-04 | Takeda Chem Ind Ltd | 自動合成装置 |
| JPH06312009A (ja) * | 1993-04-28 | 1994-11-08 | Daiichi Rajio Isotope Kenkyusho:Kk | 放射性医薬品加熱装置 |
| JP2014012684A (ja) * | 2002-03-15 | 2014-01-23 | Hammersmith Imanet Ltd | 微細加工デバイスの使用 |
| JP2004136228A (ja) * | 2002-10-18 | 2004-05-13 | Chemgenesis Inc | 液相系自動有機合成装置 |
| JP2010260799A (ja) * | 2009-04-30 | 2010-11-18 | Jfe Engineering Corp | マイクロチップを用いたｐｅｔ用標識化合物の製造方法及び装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0416446B2 (enExample) | 1992-03-24 |
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