JPS5921509A - 水酸アパタイトの製造方法 - Google Patents
水酸アパタイトの製造方法Info
- Publication number
- JPS5921509A JPS5921509A JP13247082A JP13247082A JPS5921509A JP S5921509 A JPS5921509 A JP S5921509A JP 13247082 A JP13247082 A JP 13247082A JP 13247082 A JP13247082 A JP 13247082A JP S5921509 A JPS5921509 A JP S5921509A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyapatite
- grinding
- reacted
- hydroxylapatite
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 title abstract description 24
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title abstract description 24
- 238000000227 grinding Methods 0.000 claims abstract description 18
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 238000006243 chemical reaction Methods 0.000 claims description 14
- 239000011575 calcium Substances 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 15
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract description 13
- 239000000725 suspension Substances 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 7
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract description 6
- 239000000920 calcium hydroxide Substances 0.000 abstract description 6
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract description 6
- 235000011116 calcium hydroxide Nutrition 0.000 abstract description 6
- 229910019142 PO4 Inorganic materials 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 210000000988 bone and bone Anatomy 0.000 abstract description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract description 3
- 239000010452 phosphate Substances 0.000 abstract description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract description 2
- 239000001110 calcium chloride Substances 0.000 abstract description 2
- 235000011148 calcium chloride Nutrition 0.000 abstract description 2
- 229910001628 calcium chloride Inorganic materials 0.000 abstract description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 abstract 2
- 239000003463 adsorbent Substances 0.000 abstract 1
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 abstract 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 abstract 1
- 239000005548 dental material Substances 0.000 abstract 1
- 229910000150 monocalcium phosphate Inorganic materials 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 description 9
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000007900 aqueous suspension Substances 0.000 description 5
- 239000011324 bead Substances 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
- 239000001639 calcium acetate Substances 0.000 description 2
- 235000011092 calcium acetate Nutrition 0.000 description 2
- 229960005147 calcium acetate Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- 239000004254 Ammonium phosphate Substances 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 239000005696 Diammonium phosphate Substances 0.000 description 1
- -1 P2O3 Chemical class 0.000 description 1
- 208000002697 Tooth Abrasion Diseases 0.000 description 1
- XZMPQELFUMMFEI-UHFFFAOYSA-A [Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O Chemical compound [Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XZMPQELFUMMFEI-UHFFFAOYSA-A 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 description 1
- 235000019289 ammonium phosphates Nutrition 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13247082A JPS5921509A (ja) | 1982-07-28 | 1982-07-28 | 水酸アパタイトの製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13247082A JPS5921509A (ja) | 1982-07-28 | 1982-07-28 | 水酸アパタイトの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5921509A true JPS5921509A (ja) | 1984-02-03 |
| JPS624324B2 JPS624324B2 (enrdf_load_stackoverflow) | 1987-01-29 |
Family
ID=15082122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13247082A Granted JPS5921509A (ja) | 1982-07-28 | 1982-07-28 | 水酸アパタイトの製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5921509A (enrdf_load_stackoverflow) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6287406A (ja) * | 1985-10-11 | 1987-04-21 | Agency Of Ind Science & Technol | β−リン酸三カルシウムの製造方法 |
| US4897250A (en) * | 1986-10-31 | 1990-01-30 | Asahi Kogaku Kabushiki Kaisha | Process for producing calcium phosphate |
| JPH0351396A (ja) * | 1989-04-21 | 1991-03-05 | Asahi Optical Co Ltd | 機能紙 |
| WO2000058209A1 (fr) * | 1999-03-26 | 2000-10-05 | Nara Machinery Co., Ltd. | Procede de synthese de l'hydroxyapatite, et complexe d'hydroxyapatite et son procede de preparation |
| WO2000058210A1 (fr) * | 1999-03-26 | 2000-10-05 | Nara Machinery Co., Ltd. | Procede de production de poudre de phosphate de calcium |
| CN103204485A (zh) * | 2013-04-25 | 2013-07-17 | 连云港树人科创食品添加剂有限公司 | 一种食品级磷酸三钙生产方法 |
| RU2641919C1 (ru) * | 2016-12-20 | 2018-01-23 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный университет" | Способ получения гидроксиапатита |
| JP2020117423A (ja) * | 2019-01-25 | 2020-08-06 | 株式会社バイオアパタイト | 口腔用ハイドロキシアパタイト、口腔用組成物及び口腔用ハイドロキシアパタイトの製造方法 |
-
1982
- 1982-07-28 JP JP13247082A patent/JPS5921509A/ja active Granted
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6287406A (ja) * | 1985-10-11 | 1987-04-21 | Agency Of Ind Science & Technol | β−リン酸三カルシウムの製造方法 |
| US4897250A (en) * | 1986-10-31 | 1990-01-30 | Asahi Kogaku Kabushiki Kaisha | Process for producing calcium phosphate |
| JPH0351396A (ja) * | 1989-04-21 | 1991-03-05 | Asahi Optical Co Ltd | 機能紙 |
| WO2000058209A1 (fr) * | 1999-03-26 | 2000-10-05 | Nara Machinery Co., Ltd. | Procede de synthese de l'hydroxyapatite, et complexe d'hydroxyapatite et son procede de preparation |
| WO2000058210A1 (fr) * | 1999-03-26 | 2000-10-05 | Nara Machinery Co., Ltd. | Procede de production de poudre de phosphate de calcium |
| US6592989B1 (en) | 1999-03-26 | 2003-07-15 | Nara Machinery Co., Ltd. | Method for synthesis of hydroxyapatite, and hydroxyapatite complex and method for preparing the same |
| EP1110908A4 (en) * | 1999-03-26 | 2004-12-15 | Nara Machinery Co Ltd | HYDROXYAPATITE SYNTHESIS PROCESS, AND HYDROXYAPATITE COMPLEX AND PREPARATION METHOD THEREOF |
| CN103204485A (zh) * | 2013-04-25 | 2013-07-17 | 连云港树人科创食品添加剂有限公司 | 一种食品级磷酸三钙生产方法 |
| CN103204485B (zh) * | 2013-04-25 | 2015-02-11 | 连云港树人科创食品添加剂有限公司 | 一种食品级磷酸三钙生产方法 |
| RU2641919C1 (ru) * | 2016-12-20 | 2018-01-23 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный университет" | Способ получения гидроксиапатита |
| JP2020117423A (ja) * | 2019-01-25 | 2020-08-06 | 株式会社バイオアパタイト | 口腔用ハイドロキシアパタイト、口腔用組成物及び口腔用ハイドロキシアパタイトの製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS624324B2 (enrdf_load_stackoverflow) | 1987-01-29 |
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