JPS59210086A - Ｄｘ―５２―１類及びその塩類 - Google Patents

Ｄｘ―５２―１類及びその塩類

Info

Publication number
JPS59210086A
JPS59210086A JP58083775A JP8377583A JPS59210086A JP S59210086 A JPS59210086 A JP S59210086A JP 58083775 A JP58083775 A JP 58083775A JP 8377583 A JP8377583 A JP 8377583A JP S59210086 A JPS59210086 A JP S59210086A
Authority
JP
Japan
Prior art keywords
lower alkyl
solution
water
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58083775A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0370707B2 (enExample
Inventor
Tadashi Hirata
平田　正
Shigeru Kobayashi
茂 小林
Keiichi Takahashi
恵一 高橋
Makoto Morimoto
森本　眞
Takemitsu Arai
新井　雄光
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP58083775A priority Critical patent/JPS59210086A/ja
Priority to US06/606,902 priority patent/US4650869A/en
Priority to EP84105338A priority patent/EP0128370B1/en
Priority to DE8484105338T priority patent/DE3465595D1/de
Publication of JPS59210086A publication Critical patent/JPS59210086A/ja
Publication of JPH0370707B2 publication Critical patent/JPH0370707B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP58083775A 1983-05-13 1983-05-13 Ｄｘ―５２―１類及びその塩類 Granted JPS59210086A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP58083775A JPS59210086A (ja) 1983-05-13 1983-05-13 Ｄｘ―５２―１類及びその塩類
US06/606,902 US4650869A (en) 1983-05-13 1984-05-04 DX-52-1 compounds and process for preparing the same
EP84105338A EP0128370B1 (en) 1983-05-13 1984-05-11 Diazotetracyclic compounds and process for preparing the same
DE8484105338T DE3465595D1 (en) 1983-05-13 1984-05-11 Diazotetracyclic compounds and process for preparing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58083775A JPS59210086A (ja) 1983-05-13 1983-05-13 Ｄｘ―５２―１類及びその塩類

Publications (2)

Publication Number Publication Date
JPS59210086A true JPS59210086A (ja) 1984-11-28
JPH0370707B2 JPH0370707B2 (enExample) 1991-11-08

Family

ID=13811976

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58083775A Granted JPS59210086A (ja) 1983-05-13 1983-05-13 Ｄｘ―５２―１類及びその塩類

Country Status (4)

Country Link
US (1) US4650869A (enExample)
EP (1) EP0128370B1 (enExample)
JP (1) JPS59210086A (enExample)
DE (1) DE3465595D1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988002369A1 (fr) * 1986-10-01 1988-04-07 Kyowa Hakko Kogyo Co., Ltd. Compose oncostatique du type dc-52

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60197690A (ja) * 1984-03-16 1985-10-07 Kyowa Hakko Kogyo Co Ltd Ｄｃ−５２の塩
US4822882A (en) * 1986-10-03 1989-04-18 Kyowa Hakko Kogyo Co., Ltd. DC-52 derivatives and their antitumor use
JP2569358B2 (ja) * 1988-11-16 1997-01-08 協和醗酵工業株式会社 新規化合物
CN1046516C (zh) * 1994-04-25 1999-11-17 协和发酵工业株式会社 化合物dx－52－1的稳定方法和其冻干组合物
CN1229346C (zh) * 1994-05-16 2005-11-30 默里尔药物公司 丁苯哌丁醇的非对映体盐

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988002369A1 (fr) * 1986-10-01 1988-04-07 Kyowa Hakko Kogyo Co., Ltd. Compose oncostatique du type dc-52

Also Published As

Publication number Publication date
US4650869A (en) 1987-03-17
EP0128370A3 (en) 1985-08-07
EP0128370B1 (en) 1987-08-26
DE3465595D1 (en) 1987-10-01
EP0128370A2 (en) 1984-12-19
JPH0370707B2 (enExample) 1991-11-08

Similar Documents

Publication Publication Date Title
Brzezinska et al. Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymic N-acetylation of the deoxystreptamine moiety
Ohno et al. Reduction by a model of NAD (P) H. 25. A chiral model which induces high asymmetry
US4207323A (en) 6-Substituted methyl penicillins, derivatives and analogues thereof
Naito et al. Synthesis and structure-activity relationships of a new oral cephalosporin, BMY-28100 and related compounds
JPH01132542A (ja) ゴッシポールラセミ体の光学分割法
PARKER et al. Aerocyanidin, a new antibiotic produced by Chromobacterium violaceum
Miyazaki et al. Chemical modification and structure-activity correlation of salinomycin
JPH0370707B2 (enExample)
Haskell et al. The preparation and biological activity of novel amino acid analogs of butirosin
Morimoto et al. Semisynthetic. beta.-lactam antibiotics. 2. Synthesis and properties of D-and L-. alpha.-sulfobenzylpenicillins
Norte et al. Siphonarienedione and siphonarienolone, two new metabolites from Siphonaria grisea having a polypropionate skeleton
MORISHIMA et al. SYNTHESIS OF 4-AMINO-3 HYDROXY-6-METHYLHEPTANOIG ACID, AN AMINE COMPONENT OF PEPSTATIN
DE69406110T2 (de) Farnesyl-proteintransferase inhibitoren als antikrebsmittel
US4283528A (en) 1-N-aminohydroxyacyl derivatives of gentamicin B
DE2423591A1 (de) 1-n-isoserylkanamycine
EP0517345B1 (en) Intermediates of the mureidomycin group, their preparation, and their use
US4132846A (en) 1-N-(α-Hydroxy-β-aminopropionyl) XK-62-2 and method of production thereof
US3647779A (en) Kasugamycin substituted antibacterial agents
Kuroda et al. FR-900137, A NEW ANTIBIOTIC II. STRUCTURE DETERMINATION OF FR-900137
Hida et al. Structures of New Pseudo-Peptide Antibiotics, Sperabillins.
Naito et al. Chemical modification of sorbistin I. N-Acyl analogs of sorbistin
JPH01301657A (ja) 新規アンドリミド誘導体
JPS6363681A (ja) （１ｒ）−１−メチルカルバペネム−３−カルボン酸誘導体
JPH0395185A (ja) ペネム―３―カルボン酸エステル誘導体
JPH0381258A (ja) 新規なドーパ誘導体