JPS59157021A - 動脈硬化症予防治療剤 - Google Patents
動脈硬化症予防治療剤Info
- Publication number
- JPS59157021A JPS59157021A JP58031515A JP3151583A JPS59157021A JP S59157021 A JPS59157021 A JP S59157021A JP 58031515 A JP58031515 A JP 58031515A JP 3151583 A JP3151583 A JP 3151583A JP S59157021 A JPS59157021 A JP S59157021A
- Authority
- JP
- Japan
- Prior art keywords
- diltiazem
- arteriosclerosis
- preventive
- agent
- remedy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010003210 Arteriosclerosis Diseases 0.000 title claims abstract description 18
- 208000011775 arteriosclerosis disease Diseases 0.000 title claims abstract description 18
- 230000003449 preventive effect Effects 0.000 title abstract description 5
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims abstract description 31
- 229960004166 diltiazem Drugs 0.000 claims abstract description 30
- 208000034189 Sclerosis Diseases 0.000 claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 201000003371 Monckeberg arteriosclerosis Diseases 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 7
- 201000001320 Atherosclerosis Diseases 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 230000002008 hemorrhagic effect Effects 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 8
- 230000003902 lesion Effects 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract description 2
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- HDRXZJPWHTXQRI-BHDTVMLSSA-N diltiazem hydrochloride Chemical compound [Cl-].C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CC[NH+](C)C)C2=CC=CC=C2S1 HDRXZJPWHTXQRI-BHDTVMLSSA-N 0.000 description 6
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- 235000009200 high fat diet Nutrition 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 206010065558 Aortic arteriosclerosis Diseases 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 241000446313 Lamella Species 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 101150010145 PYM gene Proteins 0.000 description 1
- 101150016203 PYM1 gene Proteins 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 201000001962 aortic atherosclerosis Diseases 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 210000001841 basilar artery Anatomy 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
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- 239000002775 capsule Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 210000004913 chyme Anatomy 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
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- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
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- 208000014674 injury Diseases 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
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- 239000000312 peanut oil Substances 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical class OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 210000002254 renal artery Anatomy 0.000 description 1
- 230000002784 sclerotic effect Effects 0.000 description 1
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- ZEMGGZBWXRYJHK-UHFFFAOYSA-N thiouracil Chemical compound O=C1C=CNC(=S)N1 ZEMGGZBWXRYJHK-UHFFFAOYSA-N 0.000 description 1
- 229950000329 thiouracil Drugs 0.000 description 1
- 210000002465 tibial artery Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58031515A JPS59157021A (ja) | 1983-02-25 | 1983-02-25 | 動脈硬化症予防治療剤 |
| NL8400548A NL8400548A (nl) | 1983-02-25 | 1984-02-21 | Farmaceutische preparaat voor de profylaxe en behandeling van arteriosclerose. |
| SE8400971A SE8400971L (sv) | 1983-02-25 | 1984-02-22 | Profylaktiskt och lekande medel for arterioskleros |
| DE19843406837 DE3406837A1 (de) | 1983-02-25 | 1984-02-24 | Arteriosklerose-arzneimittel und -prophylaktikum |
| DK103084A DK163712C (da) | 1983-02-25 | 1984-02-24 | Anvendelse af diltiazem eller et farmaceutisk acceptabelt syreadditionssalt deraf |
| CH925/84A CH658389A5 (de) | 1983-02-25 | 1984-02-24 | Pharmazeutisches mittel fuer prophylaxe und behandlung von arteriosklerose. |
| IT8467183A IT1178863B (it) | 1983-02-25 | 1984-02-24 | Composizione farmaceutica per la profilassi ed il trattemento della arteriosclerosi |
| FR8402895A FR2541577B1 (fr) | 1983-02-25 | 1984-02-24 | Nouveau medicament pour la prophylaxie et la guerison de l'arteriosclerose |
| BE0/212448A BE899000A (fr) | 1983-02-25 | 1984-02-24 | Compositions a base de diltiazem pour la prophylaxie et le traitement des arterioscleroses |
| GB08405060A GB2135192B (en) | 1983-02-25 | 1984-02-27 | Diltiazem for the treatment of arteriosclerosis |
| SG211/89A SG21189G (en) | 1983-02-25 | 1989-04-07 | Prophylactic and curing agent for arteriosclerosis |
| HK453/89A HK45389A (en) | 1983-02-25 | 1989-06-07 | Prophylactic and curing agent for arteriosclerosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58031515A JPS59157021A (ja) | 1983-02-25 | 1983-02-25 | 動脈硬化症予防治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59157021A true JPS59157021A (ja) | 1984-09-06 |
| JPS6358809B2 JPS6358809B2 (enrdf_load_stackoverflow) | 1988-11-17 |
Family
ID=12333337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58031515A Granted JPS59157021A (ja) | 1983-02-25 | 1983-02-25 | 動脈硬化症予防治療剤 |
Country Status (12)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63107925A (ja) * | 1986-05-23 | 1988-05-12 | Tanabe Seiyaku Co Ltd | 動脈硬化症予防・治療剤 |
| JPS63107926A (ja) * | 1986-05-16 | 1988-05-12 | Tanabe Seiyaku Co Ltd | 血中脂質改善剤 |
| JPH06172180A (ja) * | 1992-12-10 | 1994-06-21 | Tanabe Seiyaku Co Ltd | 抗動脈硬化剤 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562257A (en) * | 1967-10-28 | 1971-02-09 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| GB1236467A (en) * | 1967-10-28 | 1971-06-23 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
-
1983
- 1983-02-25 JP JP58031515A patent/JPS59157021A/ja active Granted
-
1984
- 1984-02-21 NL NL8400548A patent/NL8400548A/nl not_active Application Discontinuation
- 1984-02-22 SE SE8400971A patent/SE8400971L/ unknown
- 1984-02-24 CH CH925/84A patent/CH658389A5/de not_active IP Right Cessation
- 1984-02-24 DK DK103084A patent/DK163712C/da not_active IP Right Cessation
- 1984-02-24 IT IT8467183A patent/IT1178863B/it active
- 1984-02-24 BE BE0/212448A patent/BE899000A/fr not_active IP Right Cessation
- 1984-02-24 DE DE19843406837 patent/DE3406837A1/de active Granted
- 1984-02-24 FR FR8402895A patent/FR2541577B1/fr not_active Expired
- 1984-02-27 GB GB08405060A patent/GB2135192B/en not_active Expired
-
1989
- 1989-04-07 SG SG211/89A patent/SG21189G/en unknown
- 1989-06-07 HK HK453/89A patent/HK45389A/xx not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63107926A (ja) * | 1986-05-16 | 1988-05-12 | Tanabe Seiyaku Co Ltd | 血中脂質改善剤 |
| JPS63107925A (ja) * | 1986-05-23 | 1988-05-12 | Tanabe Seiyaku Co Ltd | 動脈硬化症予防・治療剤 |
| JPH06172180A (ja) * | 1992-12-10 | 1994-06-21 | Tanabe Seiyaku Co Ltd | 抗動脈硬化剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| DK163712B (da) | 1992-03-30 |
| GB8405060D0 (en) | 1984-04-04 |
| FR2541577B1 (fr) | 1987-05-22 |
| FR2541577A1 (fr) | 1984-08-31 |
| GB2135192A (en) | 1984-08-30 |
| IT1178863B (it) | 1987-09-16 |
| IT8467183A1 (it) | 1985-08-24 |
| SE8400971D0 (sv) | 1984-02-22 |
| SG21189G (en) | 1990-01-26 |
| HK45389A (en) | 1989-06-16 |
| BE899000A (fr) | 1984-06-18 |
| DE3406837C2 (enrdf_load_stackoverflow) | 1990-12-20 |
| IT8467183A0 (it) | 1984-02-24 |
| DK163712C (da) | 1992-08-31 |
| DK103084D0 (da) | 1984-02-24 |
| NL8400548A (nl) | 1984-09-17 |
| GB2135192B (en) | 1986-10-22 |
| DE3406837A1 (de) | 1984-08-30 |
| DK103084A (da) | 1984-08-26 |
| CH658389A5 (de) | 1986-11-14 |
| SE8400971L (sv) | 1984-08-26 |
| JPS6358809B2 (enrdf_load_stackoverflow) | 1988-11-17 |
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