JPS59141564A - 新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤 - Google Patents

新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤

Info

Publication number
JPS59141564A
JPS59141564A JP59013234A JP1323484A JPS59141564A JP S59141564 A JPS59141564 A JP S59141564A JP 59013234 A JP59013234 A JP 59013234A JP 1323484 A JP1323484 A JP 1323484A JP S59141564 A JPS59141564 A JP S59141564A
Authority
JP
Japan
Prior art keywords
group
lower alkyl
alkyl group
formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP59013234A
Other languages
English (en)
Japanese (ja)
Inventor
ジヤン−ピエール・シヤンボン
カトリーン・ビジエール
カミユージヨルジユ・ヴエルミユト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JPS59141564A publication Critical patent/JPS59141564A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP59013234A 1983-01-27 1984-01-27 新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤 Pending JPS59141564A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8301234A FR2540113A1 (fr) 1983-01-27 1983-01-27 Acides derives de la pyridazine actifs sur le systeme nerveux central

Publications (1)

Publication Number Publication Date
JPS59141564A true JPS59141564A (ja) 1984-08-14

Family

ID=9285330

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59013234A Pending JPS59141564A (ja) 1983-01-27 1984-01-27 新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤

Country Status (27)

Country Link
US (1) US4721711A (enExample)
EP (1) EP0117779B1 (enExample)
JP (1) JPS59141564A (enExample)
KR (1) KR910000638B1 (enExample)
AR (1) AR240045A1 (enExample)
AT (1) ATE48417T1 (enExample)
AU (2) AU2372984A (enExample)
CA (1) CA1238637A (enExample)
DD (1) DD220026A5 (enExample)
DE (1) DE3480653D1 (enExample)
DK (1) DK162985C (enExample)
ES (1) ES8500243A1 (enExample)
FI (1) FI78691C (enExample)
FR (1) FR2540113A1 (enExample)
HU (1) HU193890B (enExample)
IE (1) IE57054B1 (enExample)
IL (1) IL70756A (enExample)
MA (1) MA20018A1 (enExample)
NO (1) NO840313L (enExample)
NZ (1) NZ206945A (enExample)
OA (1) OA07644A (enExample)
PH (1) PH21162A (enExample)
PL (1) PL142340B1 (enExample)
PT (1) PT77993B (enExample)
SG (1) SG93690G (enExample)
YU (1) YU14284A (enExample)
ZA (1) ZA84502B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
DE3664772D1 (en) * 1985-01-14 1989-09-07 Boehringer Ingelheim Kg 12-amino pyridazinoû4',5':3,4¨pyrroloû2,1-a¨isoquinolines, process for their preparation and use
US5082939A (en) * 1987-01-08 1992-01-21 I.S.F. Societa Per Azioni Pyridazine derivatives
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
US5631255A (en) * 1989-02-07 1997-05-20 Sanofi Pyridazine derivatives
FR2668151A1 (fr) * 1990-10-23 1992-04-24 Rhone Poulenc Agrochimie Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant.
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
CN1038249C (zh) * 1991-08-28 1998-05-06 罗姆和哈斯公司 含有二氢哒嗪酮及其相关化合物的杀菌组合物
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
EP1430033A4 (en) * 2001-08-31 2004-12-15 Univ Northwestern ANTI-INFLAMMATORY AND PROTEIN-INK-INHIBITING COMPOSITION AND THEIR USE
JP5337375B2 (ja) * 2004-11-02 2013-11-06 ノースウェスタン ユニバーシティ ピリダジン化合物、組成物および方法
WO2006050359A2 (en) * 2004-11-02 2006-05-11 Northwestern University Pyridazine compounds and methods
EP2015751A2 (en) * 2006-04-28 2009-01-21 Northwestern University Salts of pyridazine compounds
CA2650625A1 (en) * 2006-04-28 2007-11-08 Northwestern University Formulations containing pyridazine compounds for treating neuroinflammatory diseases
CA2650711A1 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
BRPI0809498A2 (pt) * 2007-04-02 2014-09-23 Inst Oneworld Health Compostos inibidores de cftr e seus usos
WO2009131958A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising triazine derivatives
WO2009131951A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
US8207205B2 (en) 2008-04-21 2012-06-26 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
US20090270398A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
WO2010033626A1 (en) * 2008-09-19 2010-03-25 Institute For Oneworld Health Compounds, compositions and methods comprising imidazole and triazole derivatives
US8343976B2 (en) * 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
US20100267706A1 (en) * 2009-04-20 2010-10-21 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2510997A1 (fr) * 1981-08-10 1983-02-11 Sanofi Sa Nouveaux derives de la methyl-4 phenyl-6 pyridazine, procede pour leur preparation et medicaments actifs sur le systeme nerveux central en contenant
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
CA1218655A (en) * 1983-01-28 1987-03-03 Kathleen Biziere Process for the preparation of pyridazine derivatives having a psychotropic action

Also Published As

Publication number Publication date
YU14284A (en) 1986-12-31
IL70756A0 (en) 1984-04-30
IL70756A (en) 1987-03-31
PT77993B (fr) 1986-04-10
PH21162A (en) 1987-08-05
DD220026A5 (de) 1985-03-20
AU2372984A (en) 1984-08-02
HU193890B (en) 1987-12-28
KR910000638B1 (ko) 1991-01-31
IE840149L (en) 1984-07-27
IE57054B1 (en) 1992-04-08
PL142340B1 (en) 1987-10-31
AR240045A1 (es) 1990-01-31
ES529081A0 (es) 1984-10-01
AU2142188A (en) 1989-03-16
OA07644A (fr) 1985-05-23
DE3480653D1 (de) 1990-01-11
PL245931A1 (en) 1985-07-16
ZA84502B (en) 1984-09-26
FR2540113B1 (enExample) 1985-05-17
FI840323L (fi) 1984-07-28
NO840313L (no) 1984-07-30
DK162985C (da) 1992-06-01
NZ206945A (en) 1987-07-31
FR2540113A1 (fr) 1984-08-03
DK38984A (da) 1984-07-28
PT77993A (fr) 1984-02-01
EP0117779B1 (fr) 1989-12-06
ATE48417T1 (de) 1989-12-15
ES8500243A1 (es) 1984-10-01
FI840323A0 (fi) 1984-01-26
AU652118B2 (en) 1994-08-18
DK162985B (da) 1992-01-06
FI78691C (fi) 1989-09-11
US4721711A (en) 1988-01-26
CA1238637A (en) 1988-06-28
DK38984D0 (da) 1984-01-27
SG93690G (en) 1991-01-18
FI78691B (fi) 1989-05-31
KR840007586A (ko) 1984-12-08
MA20018A1 (fr) 1984-10-01
EP0117779A1 (fr) 1984-09-05

Similar Documents

Publication Publication Date Title
JPS59141564A (ja) 新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤
JP5123949B2 (ja) 非ヌクレオシド逆転写酵素阻害剤
JP5060957B2 (ja) 複素環化合物、その製造方法並びに用途
JP7671245B2 (ja) ピリダジノン化合物およびその使用
JPH02295978A (ja) フェニルピリミドン誘導体
TW200904425A (en) Organic compounds
TW200913997A (en) Heterocyclic compounds
CN103596568A (zh) 治疗帕金森病的方法以及组合物
BR112015007731B1 (pt) Composto, composição farmacêutica que o compreende e uso do mesmo
JPH09508137A (ja) セロトニンアゴニストおよびアンタゴニストとしての４−インドール誘導体
JP2004533447A (ja) 副腎皮質刺激ホルモン放出因子リガンドとしての置換ピラジノン、ピリジン及びピリミジン
JP2000128883A (ja) 性的機能障害の治療用のピラゾロピリミジノンｃＧＭＰＰＤＥ５阻害剤
CN103582478A (zh) 治疗神经退行性疾病的方法和组合物
TW200406387A (en) Compounds, methods and compositions
EA002907B1 (ru) Производные 6-фенилпиридил-2-амина, полезные в качестве ингибиторов nos
TW200936570A (en) 2-aminopyrimidine derivatives
WO2007007778A1 (ja) プロスタグランジンｄ合成酵素を阻害するベンゾイミダゾール化合物
JPH10231297A (ja) 新規なアデニン−１−ｎ−オキシド誘導体およびその医薬用途
JPWO2009041559A1 (ja) インダゾールアクリル酸アミド化合物
WO1998009960A1 (en) 2,4-disubstituted pyrimidine derivatives, process for producing the same, and medicinal compositions containing the same
US6670362B2 (en) Pyridazine endothelin antagonists
US20020025948A1 (en) 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
JP2007523206A (ja) Ｃｂ２受容体モジュレーターとしてのピリジン誘導体およびその使用
JPH05221989A (ja) 複素環式化合物
NZ208956A (en) Pyrimidone derivatives