JPS59141564A - 新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤 - Google Patents

新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤

Info

Publication number
JPS59141564A
JPS59141564A JP59013234A JP1323484A JPS59141564A JP S59141564 A JPS59141564 A JP S59141564A JP 59013234 A JP59013234 A JP 59013234A JP 1323484 A JP1323484 A JP 1323484A JP S59141564 A JPS59141564 A JP S59141564A
Authority
JP
Japan
Prior art keywords
group
lower alkyl
alkyl group
formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP59013234A
Other languages
English (en)
Japanese (ja)
Inventor
ジヤン−ピエール・シヤンボン
カトリーン・ビジエール
カミユージヨルジユ・ヴエルミユト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JPS59141564A publication Critical patent/JPS59141564A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP59013234A 1983-01-27 1984-01-27 新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤 Pending JPS59141564A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8301234A FR2540113A1 (fr) 1983-01-27 1983-01-27 Acides derives de la pyridazine actifs sur le systeme nerveux central

Publications (1)

Publication Number Publication Date
JPS59141564A true JPS59141564A (ja) 1984-08-14

Family

ID=9285330

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59013234A Pending JPS59141564A (ja) 1983-01-27 1984-01-27 新規ピリダジン誘導体，その製造方法及び該誘導体を含有する神経系治療剤

Country Status (27)

Country Link
US (1) US4721711A (enExample)
EP (1) EP0117779B1 (enExample)
JP (1) JPS59141564A (enExample)
KR (1) KR910000638B1 (enExample)
AR (1) AR240045A1 (enExample)
AT (1) ATE48417T1 (enExample)
AU (2) AU2372984A (enExample)
CA (1) CA1238637A (enExample)
DD (1) DD220026A5 (enExample)
DE (1) DE3480653D1 (enExample)
DK (1) DK162985C (enExample)
ES (1) ES529081A0 (enExample)
FI (1) FI78691C (enExample)
FR (1) FR2540113A1 (enExample)
HU (1) HU193890B (enExample)
IE (1) IE57054B1 (enExample)
IL (1) IL70756A (enExample)
MA (1) MA20018A1 (enExample)
NO (1) NO840313L (enExample)
NZ (1) NZ206945A (enExample)
OA (1) OA07644A (enExample)
PH (1) PH21162A (enExample)
PL (1) PL142340B1 (enExample)
PT (1) PT77993B (enExample)
SG (1) SG93690G (enExample)
YU (1) YU14284A (enExample)
ZA (1) ZA84502B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
EP0190563B1 (de) * 1985-01-14 1989-08-02 Boehringer Ingelheim Kg Neue 12-Amino-pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und ihre Verwendung
US5082939A (en) * 1987-01-08 1992-01-21 I.S.F. Societa Per Azioni Pyridazine derivatives
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
US5631255A (en) * 1989-02-07 1997-05-20 Sanofi Pyridazine derivatives
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2668151A1 (fr) * 1990-10-23 1992-04-24 Rhone Poulenc Agrochimie Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant.
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
CN1038249C (zh) * 1991-08-28 1998-05-06 罗姆和哈斯公司 含有二氢哒嗪酮及其相关化合物的杀菌组合物
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
US20030176437A1 (en) * 2001-08-31 2003-09-18 D.M. Watterson Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
EP1812408B1 (en) 2004-11-02 2013-10-09 Northwestern University Pyridazine compounds, compositions and methods
WO2006050359A2 (en) * 2004-11-02 2006-05-11 Northwestern University Pyridazine compounds and methods
WO2007127448A2 (en) * 2006-04-28 2007-11-08 Northwestern University Salts of pyridazine compounds
BRPI0710938A2 (pt) * 2006-04-28 2012-06-26 Univ Northwestern formulações contendo compostos de piridazina para o tratamento de doenças neuroinflamatórias
WO2007127474A2 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
US8283351B2 (en) * 2007-04-02 2012-10-09 Institute For Oneworld Health Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
WO2009131958A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising triazine derivatives
US8236838B2 (en) * 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
WO2009131957A2 (en) 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
US20090270398A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
WO2010033626A1 (en) * 2008-09-19 2010-03-25 Institute For Oneworld Health Compounds, compositions and methods comprising imidazole and triazole derivatives
US8343976B2 (en) * 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
US20100267706A1 (en) * 2009-04-20 2010-10-21 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2510997A1 (fr) * 1981-08-10 1983-02-11 Sanofi Sa Nouveaux derives de la methyl-4 phenyl-6 pyridazine, procede pour leur preparation et medicaments actifs sur le systeme nerveux central en contenant
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
US4565814A (en) * 1983-01-28 1986-01-21 Sanofi Pyridazine derivatives having a psychotropic action and compositions

Also Published As

Publication number Publication date
EP0117779A1 (fr) 1984-09-05
YU14284A (en) 1986-12-31
ES8500243A1 (es) 1984-10-01
FI78691C (fi) 1989-09-11
FI840323L (fi) 1984-07-28
DK162985B (da) 1992-01-06
DE3480653D1 (de) 1990-01-11
IL70756A (en) 1987-03-31
FR2540113A1 (fr) 1984-08-03
DD220026A5 (de) 1985-03-20
NZ206945A (en) 1987-07-31
FI840323A0 (fi) 1984-01-26
DK38984A (da) 1984-07-28
AR240045A1 (es) 1990-01-31
NO840313L (no) 1984-07-30
US4721711A (en) 1988-01-26
ZA84502B (en) 1984-09-26
CA1238637A (en) 1988-06-28
FI78691B (fi) 1989-05-31
PL245931A1 (en) 1985-07-16
AU2142188A (en) 1989-03-16
AU2372984A (en) 1984-08-02
ES529081A0 (es) 1984-10-01
IL70756A0 (en) 1984-04-30
DK162985C (da) 1992-06-01
ATE48417T1 (de) 1989-12-15
SG93690G (en) 1991-01-18
KR840007586A (ko) 1984-12-08
EP0117779B1 (fr) 1989-12-06
AU652118B2 (en) 1994-08-18
FR2540113B1 (enExample) 1985-05-17
HU193890B (en) 1987-12-28
PT77993B (fr) 1986-04-10
KR910000638B1 (ko) 1991-01-31
PL142340B1 (en) 1987-10-31
OA07644A (fr) 1985-05-23
PH21162A (en) 1987-08-05
DK38984D0 (da) 1984-01-27
IE840149L (en) 1984-07-27
PT77993A (fr) 1984-02-01
MA20018A1 (fr) 1984-10-01
IE57054B1 (en) 1992-04-08

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