JPS59134720A - 抗腫瘍薬 - Google Patents
抗腫瘍薬Info
- Publication number
- JPS59134720A JPS59134720A JP813483A JP813483A JPS59134720A JP S59134720 A JPS59134720 A JP S59134720A JP 813483 A JP813483 A JP 813483A JP 813483 A JP813483 A JP 813483A JP S59134720 A JPS59134720 A JP S59134720A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reaction
- alkyl
- compound
- tropolone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 4
- 150000004696 coordination complex Chemical class 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract description 7
- 239000011541 reaction mixture Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- MDYOLVRUBBJPFM-UHFFFAOYSA-N tropolone Chemical compound OC1=CC=CC=CC1=O MDYOLVRUBBJPFM-UHFFFAOYSA-N 0.000 abstract 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000012300 argon atmosphere Substances 0.000 abstract 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- MAQMEXSLUSZDQM-UHFFFAOYSA-N diethoxymethylbenzene Chemical compound CCOC(OCC)C1=CC=CC=C1 MAQMEXSLUSZDQM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 229930007845 β-thujaplicin Natural products 0.000 abstract 1
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 229910052786 argon Inorganic materials 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- -1 11-inopro Chemical class 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- SRCZQMGIVIYBBJ-UHFFFAOYSA-N ethoxyethane;ethyl acetate Chemical compound CCOCC.CCOC(C)=O SRCZQMGIVIYBBJ-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000010898 silica gel chromatography Methods 0.000 description 2
- 150000001218 Thorium Chemical class 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000009702 cancer cell proliferation Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP813483A JPS59134720A (ja) | 1983-01-20 | 1983-01-20 | 抗腫瘍薬 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP813483A JPS59134720A (ja) | 1983-01-20 | 1983-01-20 | 抗腫瘍薬 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58181088A Division JPS59134745A (ja) | 1983-09-28 | 1983-09-28 | 抗腫瘍作用を有するトロポロン誘導体 |
| JP18108783A Division JPS59134744A (ja) | 1983-09-28 | 1983-09-28 | 抗腫瘍作用を有するトロポロン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59134720A true JPS59134720A (ja) | 1984-08-02 |
| JPH0414089B2 JPH0414089B2 (enrdf_load_stackoverflow) | 1992-03-11 |
Family
ID=11684813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP813483A Granted JPS59134720A (ja) | 1983-01-20 | 1983-01-20 | 抗腫瘍薬 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59134720A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015526396A (ja) * | 2012-06-22 | 2015-09-10 | ユニバーシティ オブ コネチカット | 置換トロポロン誘導体およびその使用方法 |
-
1983
- 1983-01-20 JP JP813483A patent/JPS59134720A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015526396A (ja) * | 2012-06-22 | 2015-09-10 | ユニバーシティ オブ コネチカット | 置換トロポロン誘導体およびその使用方法 |
| US9790158B2 (en) | 2012-06-22 | 2017-10-17 | University Of Connecticut | Substituted tropolone derivatives and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0414089B2 (enrdf_load_stackoverflow) | 1992-03-11 |
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