JPS59104377A - アミノ酸チオラクトン - Google Patents

アミノ酸チオラクトン

Info

Publication number
JPS59104377A
JPS59104377A JP58208909A JP20890983A JPS59104377A JP S59104377 A JPS59104377 A JP S59104377A JP 58208909 A JP58208909 A JP 58208909A JP 20890983 A JP20890983 A JP 20890983A JP S59104377 A JPS59104377 A JP S59104377A
Authority
JP
Japan
Prior art keywords
lower alkyl
hydrogen
formula
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58208909A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0421671B2 (enExample
Inventor
エドマンド・フランシス・バ−ン
グレン・ルイズ・トルマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS59104377A publication Critical patent/JPS59104377A/ja
Publication of JPH0421671B2 publication Critical patent/JPH0421671B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
JP58208909A 1982-11-08 1983-11-07 アミノ酸チオラクトン Granted JPS59104377A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US439960 1982-11-08
US06/439,960 US4434151A (en) 1982-11-08 1982-11-08 Bifunctional chelating agents

Publications (2)

Publication Number Publication Date
JPS59104377A true JPS59104377A (ja) 1984-06-16
JPH0421671B2 JPH0421671B2 (enExample) 1992-04-13

Family

ID=23746836

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58208909A Granted JPS59104377A (ja) 1982-11-08 1983-11-07 アミノ酸チオラクトン

Country Status (8)

Country Link
US (1) US4434151A (enExample)
EP (1) EP0108406B1 (enExample)
JP (1) JPS59104377A (enExample)
AT (1) ATE27282T1 (enExample)
CA (3) CA1251453A (enExample)
DE (1) DE3371635D1 (enExample)
DK (1) DK507183A (enExample)
NO (1) NO834063L (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06503352A (ja) * 1991-02-08 1994-04-14 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
JP2006522332A (ja) * 2003-03-05 2006-09-28 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ アフィニティリガンドの製造法
JP2006523220A (ja) * 2003-03-05 2006-10-12 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ マルチモードアニオン交換リガンドの製造法
JP2006523308A (ja) * 2003-03-05 2006-10-12 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 疎水性相互作用クロマトグラフィー用リガンドの製造法
JP2007528835A (ja) * 2003-02-28 2007-10-18 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 金属キレートアフィニティリガンドの合成方法

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4575556A (en) * 1982-11-08 1986-03-11 Medi-Physics, Inc. Bifunctional chelating agents
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4670406A (en) * 1984-01-06 1987-06-02 Becton Dickinson And Company Tracers for use in assays
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
US4670545A (en) * 1984-05-11 1987-06-02 University Patents, Inc. Chelating agents for technetium-99M
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4746505A (en) * 1985-04-26 1988-05-24 President And Fellows Of Harvard College Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
EP0200211A1 (en) * 1985-05-01 1986-11-05 The Research Foundation Of State University Of New York Diagnostic radiopharmaceutical compounds
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
US5091514A (en) * 1987-03-26 1992-02-25 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
US5021556A (en) * 1987-07-22 1991-06-04 Neorx Corporation Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides
US4871836A (en) * 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes
US5202451A (en) * 1988-02-17 1993-04-13 Neorx Corporation Anchimeric radiometal chelating compounds
US4917878A (en) * 1988-05-02 1990-04-17 Thomas Jefferson University Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
EP0489061A4 (en) * 1989-08-24 1992-10-14 Australian Nuclear Science And Technology Organisation Radio-labelled antibodies for imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5951964A (en) * 1993-06-04 1999-09-14 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6171576B1 (en) 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
CA2285516C (en) 1999-05-12 2010-12-07 President And Fellows Of Harvard College Dopamine transporter imaging agents
DE20120708U1 (de) 2001-10-09 2002-08-01 Blundell, Paul, Sommerville, Mass. Tropan-Analoga zur Inhibierung des Monoamin-Transports
JP2006515630A (ja) * 2003-01-22 2006-06-01 ザ ジェネラル ホスピタル コーポレイション アミロイド結合性金属キレート剤
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
GB2482739A (en) * 2010-08-13 2012-02-15 Univ Reading Processes and compounds useful in peptide synthesis
EP2886550A1 (en) * 2013-12-23 2015-06-24 Centre National de la Recherche Scientifique (C.N.R.S.) Dynamic molecules and dynamic combinatorial library

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2551480C3 (de) 1975-11-15 1982-04-22 Hoechst Ag, 6000 Frankfurt Technetium-99m-markiertes Nierendiagnostikum und Verfahren zu seiner Herstellung
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
US4255443A (en) 1979-11-16 1981-03-10 The United States Of America As Represented By The Department Of Health, Education And Welfare Homocysteine thiolactone perchlorate as a tumor promotor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06503352A (ja) * 1991-02-08 1994-04-14 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
JP2007528835A (ja) * 2003-02-28 2007-10-18 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 金属キレートアフィニティリガンドの合成方法
JP2006522332A (ja) * 2003-03-05 2006-09-28 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ アフィニティリガンドの製造法
JP2006523220A (ja) * 2003-03-05 2006-10-12 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ マルチモードアニオン交換リガンドの製造法
JP2006523308A (ja) * 2003-03-05 2006-10-12 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 疎水性相互作用クロマトグラフィー用リガンドの製造法

Also Published As

Publication number Publication date
CA1281500C (en) 1991-03-12
JPH0421671B2 (enExample) 1992-04-13
EP0108406A3 (en) 1985-10-23
EP0108406A2 (en) 1984-05-16
EP0108406B1 (en) 1987-05-20
CA1281499C (en) 1991-03-12
NO834063L (no) 1984-05-09
US4434151A (en) 1984-02-28
DE3371635D1 (en) 1987-06-25
ATE27282T1 (de) 1987-06-15
DK507183D0 (da) 1983-11-04
DK507183A (da) 1984-05-09
CA1251453A (en) 1989-03-21

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