JPS5874617A - 人由来血液凝固第７因子含有水溶液の加熱処理方法 - Google Patents

人由来血液凝固第７因子含有水溶液の加熱処理方法

Info

Publication number
JPS5874617A
JPS5874617A JP56173585A JP17358581A JPS5874617A JP S5874617 A JPS5874617 A JP S5874617A JP 56173585 A JP56173585 A JP 56173585A JP 17358581 A JP17358581 A JP 17358581A JP S5874617 A JPS5874617 A JP S5874617A
Authority
JP
Japan
Prior art keywords
aqueous solution
acid
factor
human
blood coagulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56173585A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0348170B2 (esLanguage
Inventor
Yoshiro Iga
伊賀　善郎
Tadakazu Suyama
須山　忠和
Ryoichi Naito
内藤　良一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
GC Biopharma Corp
Original Assignee
Green Cross Corp Japan
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan, Green Cross Corp Korea filed Critical Green Cross Corp Japan
Priority to JP56173585A priority Critical patent/JPS5874617A/ja
Priority to US06/350,150 priority patent/US4446134A/en
Priority to DE8282101408T priority patent/DE3279807D1/de
Priority to EP82101408A priority patent/EP0077870B1/en
Priority to AT82101408T priority patent/ATE44465T1/de
Priority to ES509941A priority patent/ES509941A0/es
Publication of JPS5874617A publication Critical patent/JPS5874617A/ja
Publication of JPH0348170B2 publication Critical patent/JPH0348170B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2103/05—

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP56173585A 1981-10-28 1981-10-28 人由来血液凝固第７因子含有水溶液の加熱処理方法 Granted JPS5874617A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP56173585A JPS5874617A (ja) 1981-10-28 1981-10-28 人由来血液凝固第７因子含有水溶液の加熱処理方法
US06/350,150 US4446134A (en) 1981-10-28 1982-02-19 Process for heat treatment of aqueous solution containing human blood coagulation factor VIII
DE8282101408T DE3279807D1 (en) 1981-10-28 1982-02-24 Process for heat treatment of aqueous solution containing human blood coagulation factor viii
EP82101408A EP0077870B1 (en) 1981-10-28 1982-02-24 Process for heat treatment of aqueous solution containing human blood coagulation factor viii
AT82101408T ATE44465T1 (de) 1981-10-28 1982-02-24 Verfahren zur waermebehandlung einer den menschlichen blutgerinnungsfaktor viii enthaltenden waessrigen loesung.
ES509941A ES509941A0 (es) 1981-10-28 1982-02-26 "un procedimiento para tratar termicamente con fines de inactivacion el virus de la hepatitis en una composicion de factor viii de coagulacion de la sangre humana".

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56173585A JPS5874617A (ja) 1981-10-28 1981-10-28 人由来血液凝固第７因子含有水溶液の加熱処理方法

Publications (2)

Publication Number Publication Date
JPS5874617A true JPS5874617A (ja) 1983-05-06
JPH0348170B2 JPH0348170B2 (esLanguage) 1991-07-23

Family

ID=15963301

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56173585A Granted JPS5874617A (ja) 1981-10-28 1981-10-28 人由来血液凝固第７因子含有水溶液の加熱処理方法

Country Status (6)

Country Link
US (1) US4446134A (esLanguage)
EP (1) EP0077870B1 (esLanguage)
JP (1) JPS5874617A (esLanguage)
AT (1) ATE44465T1 (esLanguage)
DE (1) DE3279807D1 (esLanguage)
ES (1) ES509941A0 (esLanguage)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581231A (en) * 1982-06-10 1986-04-08 The United States Of America As Represented By The Secretary Of Health And Human Services Inactivation of viruses containing essential lipids
DE3481109D1 (de) * 1983-05-09 1990-03-01 Novo Nordisk As Antihaemophilie-faktor-viii-konzentrat und dessen herstellungsverfahren.
DE3330770A1 (de) * 1983-08-26 1985-03-14 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von humanplasma
US4615886A (en) * 1983-08-31 1986-10-07 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Utilizing a halohydrocarbon containing dissolved water to inactivate a lipid virus
AT389815B (de) * 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4797388A (en) * 1984-05-21 1989-01-10 Cetus Corporation Pharmaceutical compositions with galactitol as carrier
JPH0669961B2 (ja) * 1984-09-25 1994-09-07 株式会社ミドリ十字 免疫グロブリンの加熱処理方法
US4670394A (en) * 1984-11-16 1987-06-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Isolation and culture of adrenal medullary endothelial cells producing blood clotting factor VIII:C
JPH0825902B2 (ja) * 1985-02-21 1996-03-13 株式会社ミドリ十字 γ−グロブリンの加熱処理方法
AT390560B (de) * 1986-05-30 1990-05-25 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern
US4749783A (en) * 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
DE3625090A1 (de) * 1986-07-24 1988-01-28 Behringwerke Ag Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung
GB8628104D0 (en) * 1986-11-25 1986-12-31 Connaught Lab Pasteurization of immunoglobin solutions
WO1988008710A1 (en) * 1987-05-15 1988-11-17 Rubinstein Alan I Sequential improved method for treatment of human blood-clotting factor products
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
IL86417A (en) * 1987-05-22 1992-09-06 Armour Pharma Process for the inactivation of pathogens in biological or pharmaceutical material by mixing with aqueous solution containing a sugar(alcohol)and neutral salts as stabilizers
DE3805459A1 (de) * 1988-02-22 1989-08-31 Biotest Pharma Gmbh Verfahren zur sterilisation von blut, plasma, blut- und plasmaderivaten, zellsuspensionen oder dgl.
US4939176A (en) * 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
DE4001451A1 (de) * 1990-01-19 1991-08-01 Octapharma Ag Stabile injizierbare loesungen von faktor viii und faktor ix
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
SE9302006D0 (sv) * 1992-10-02 1993-06-11 Kabi Pharmacia Ab Protein formulation
EP0674531A1 (de) * 1992-12-16 1995-10-04 IMMUNO Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates
JP3220539B2 (ja) * 1992-12-25 2001-10-22 日本ケミカルリサーチ株式会社 活性乳蛋白成分含有製品およびその製造法
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US6288030B1 (en) 1993-12-22 2001-09-11 Amgen Inc. Stem cell factor formulations and methods
WO1997027878A1 (en) * 1996-02-05 1997-08-07 Asahi Medical Co., Ltd. Sterile protective agent and method for sterilization
AUPO871997A0 (en) * 1997-08-25 1997-09-18 Csl Limited Dried biologically or therapeutically active preparations
CN1075736C (zh) * 1997-12-30 2001-12-05 长春市中心血站 高密度脂蛋白制剂的病毒灭活方法
DK2130554T3 (da) 1999-02-22 2012-12-03 Univ Connecticut Albuminfrie faktor VIII-præparater
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
KR100624013B1 (ko) 2004-06-25 2006-09-19 주식회사 녹십자홀딩스 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
ES2706296T3 (es) * 2008-11-07 2019-03-28 Univ Connecticut Formulaciones de Factor VIII
PT3135687T (pt) 2015-08-31 2019-05-21 Inst Grifols S A Método para preparação de imunoglobulinas

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118819A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable antitrypsin
JPS51118820A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable macroglobulin
JPS56135418A (en) * 1980-03-27 1981-10-22 Green Cross Corp:The Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2705230A (en) * 1949-09-23 1955-03-29 Allen F Reid Method of purifying albumin
US4089944A (en) * 1975-12-22 1978-05-16 Baxter Travenol Laboratories, Inc. Rapidly solubilized AHF composition and process for preparing same
US4027013A (en) * 1976-01-22 1977-05-31 William L. Wilson Clottable fibrinogen free factor VIII and albumin product and process
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118819A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable antitrypsin
JPS51118820A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable macroglobulin
JPS56135418A (en) * 1980-03-27 1981-10-22 Green Cross Corp:The Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human

Also Published As

Publication number Publication date
EP0077870A2 (en) 1983-05-04
EP0077870B1 (en) 1989-07-12
US4446134A (en) 1984-05-01
JPH0348170B2 (esLanguage) 1991-07-23
EP0077870A3 (en) 1983-11-09
ES8302772A1 (es) 1983-01-16
ES509941A0 (es) 1983-01-16
DE3279807D1 (en) 1989-08-17
ATE44465T1 (de) 1989-07-15

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