JPS58150572A - ５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル - Google Patents
５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシルInfo
- Publication number
- JPS58150572A JPS58150572A JP57033252A JP3325282A JPS58150572A JP S58150572 A JPS58150572 A JP S58150572A JP 57033252 A JP57033252 A JP 57033252A JP 3325282 A JP3325282 A JP 3325282A JP S58150572 A JPS58150572 A JP S58150572A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- fluoro
- uracil
- trifluoromethylpropionyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 title claims abstract description 14
- 229940035893 uracil Drugs 0.000 title claims abstract description 7
- 238000006243 chemical reaction Methods 0.000 abstract description 11
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract description 9
- 239000002904 solvent Substances 0.000 abstract description 8
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract description 2
- 230000000259 anti-tumor effect Effects 0.000 abstract description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract description 2
- DQOGDQIDOONUSK-UHFFFAOYSA-N 3,3,3-trifluoro-2-methylpropanoic acid Chemical compound OC(=O)C(C)C(F)(F)F DQOGDQIDOONUSK-UHFFFAOYSA-N 0.000 abstract 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960002949 fluorouracil Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- WADSJYLPJPTMLN-UHFFFAOYSA-N 3-(cycloundecen-1-yl)-1,2-diazacycloundec-2-ene Chemical compound C1CCCCCCCCC=C1C1=NNCCCCCCCC1 WADSJYLPJPTMLN-UHFFFAOYSA-N 0.000 description 1
- ZARBPJCRKSPIRN-UHFFFAOYSA-N 6-fluoro-1h-pyrimidine-2,4-dione Chemical class FC1=CC(=O)NC(=O)N1 ZARBPJCRKSPIRN-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- -1 tetrahydro7rane Chemical compound 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57033252A JPS58150572A (ja) | 1982-03-03 | 1982-03-03 | ５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57033252A JPS58150572A (ja) | 1982-03-03 | 1982-03-03 | ５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58150572A true JPS58150572A (ja) | 1983-09-07 |
| JPS6116391B2 JPS6116391B2 (enExample) | 1986-04-30 |
Family
ID=12381299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57033252A Granted JPS58150572A (ja) | 1982-03-03 | 1982-03-03 | ５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58150572A (enExample) |
-
1982
- 1982-03-03 JP JP57033252A patent/JPS58150572A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6116391B2 (enExample) | 1986-04-30 |
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