JPS58109473A - ２−（三置換フエニルイミノ）−イミダゾリン類 - Google Patents

２−（三置換フエニルイミノ）−イミダゾリン類

Info

Publication number
JPS58109473A
JPS58109473A JP57204429A JP20442982A JPS58109473A JP S58109473 A JPS58109473 A JP S58109473A JP 57204429 A JP57204429 A JP 57204429A JP 20442982 A JP20442982 A JP 20442982A JP S58109473 A JPS58109473 A JP S58109473A
Authority
JP
Japan
Prior art keywords
lower alkyl
trisubstituted
benzamine
solution
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57204429A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0545584B2 (enExample
Inventor
ビリ−・マ−レイ・ヨ−ク・ジユニア−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of JPS58109473A publication Critical patent/JPS58109473A/ja
Publication of JPH0545584B2 publication Critical patent/JPH0545584B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP57204429A 1981-11-20 1982-11-20 ２−（三置換フエニルイミノ）−イミダゾリン類 Granted JPS58109473A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/323,371 US4461904A (en) 1981-11-20 1981-11-20 2-(Trisubstituted phenylimino)-imidazolines
US323371 1981-11-20

Publications (2)

Publication Number Publication Date
JPS58109473A true JPS58109473A (ja) 1983-06-29
JPH0545584B2 JPH0545584B2 (enExample) 1993-07-09

Family

ID=23258934

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57204429A Granted JPS58109473A (ja) 1981-11-20 1982-11-20 ２−（三置換フエニルイミノ）−イミダゾリン類

Country Status (6)

Country Link
US (1) US4461904A (enExample)
EP (1) EP0081923B1 (enExample)
JP (1) JPS58109473A (enExample)
AT (1) ATE25079T1 (enExample)
CA (1) CA1183545A (enExample)
DE (1) DE3275184D1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3321282A1 (de) * 1983-06-13 1984-12-13 Boehringer Ingelheim KG, 6507 Ingelheim Neue 1-acetonyl-2-(phenylimino)-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
US4505926A (en) * 1983-09-15 1985-03-19 Beecham Group P.L.C. Quaternary amino imidazolidines, compositions and use
EP0236636A3 (en) * 1986-02-07 1988-12-07 Alcon Laboratories, Inc. Use of clonidine derivatives for the preparation of ocular hemostatic agents
AU585309B2 (en) * 1984-12-14 1989-06-15 Alcon Laboratories, Inc. Method for controlling ocular bleeding
US4587257A (en) * 1984-12-14 1986-05-06 Alcon Laboratories, Inc. Control of ocular bleeding using clonidine derivatives
FR2592042B1 (fr) * 1985-12-19 1988-03-25 Ile De France Nouveaux ortho-anisamides, leur procede d'obtention, et leurs applications therapeutiques
US5212196A (en) * 1986-10-21 1993-05-18 Alcon Laboratories, Inc. Control of post-surgical intraocular pressure using clonidine derivatives
US4897412A (en) * 1987-04-06 1990-01-30 Laboratories Alcon S.A. Imidazolines useful in lowering intraocular pressure
US4801617A (en) * 1987-04-06 1989-01-31 Leclerc Gerard Iminoimidazolidines useful in lowering intraocular pressure
CA1334168C (en) * 1988-04-26 1995-01-31 Louis M. De Santis Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
ES2105333T3 (es) * 1992-10-13 1997-10-16 Alcon Lab Inc Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma.
US5340572A (en) * 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
US5523316A (en) * 1994-06-23 1996-06-04 Alcon Laboratories, Inc. Intraocular irrigating solution containing agent for controlling IOP
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
US6602897B2 (en) * 2000-10-14 2003-08-05 Boehringer Ingelheim Pharma Kg m-Amino-phenylimino-imidazolidine derivatives for treating urinary incontinence
BRPI0511462A (pt) * 2004-05-25 2007-12-26 Othera Pharmaceuticals Inc medicamentos e pró-medicamentos óculo-seletivos

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56147773A (en) * 1980-03-03 1981-11-16 Merck & Co Inc Non-ovulation chicken feed composition
JPS57181060A (en) * 1981-04-24 1982-11-08 Beecham Group Ltd Imidazole derivatives, manufacture and medicinal composition containing them

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2938038A (en) * 1960-05-24 X-dihydroxyphenylamino
US3236857A (en) * 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
US3636219A (en) * 1964-03-02 1972-01-18 Du Pont Anticholinergic compositions containing certain thiazolines or imidazolines
DE1670274A1 (de) * 1966-10-31 1970-07-16 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2)
AT285599B (de) * 1968-06-21 1970-11-10 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen
US3622579A (en) * 1969-08-28 1971-11-23 Boehringer Sohn Ingelheim Derivatives of 2-anilino-1,3-diazacyclopentene-(2)
BE759125A (fr) * 1969-11-19 1971-05-18 Boehringer Sohn Ingelheim Nouvelles n-allyl-2-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer
BE759126A (fr) * 1969-11-19 1971-05-18 Boehringer Sohn Ingelheim Nouvelles n-cycloalcoyl-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer
DE2220906A1 (de) * 1972-04-28 1973-11-15 Boehringer Sohn Ingelheim Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2316377C3 (de) * 1973-04-02 1978-11-02 Lentia Gmbh, Chem. U. Pharm. Erzeugnisse - Industriebedarf, 8000 Muenchen Verfahren zur Herstellung von 2-Phenyl-amino-2-imidazolin-Derivaten und von deren Salzen
US4125620A (en) * 1974-10-01 1978-11-14 Boehringer Ingelheim Gmbh 2-[(2',6'-Disubstituted-phenyl)-imino]-imidazolidines and salts thereof
DE2630060C2 (de) * 1976-07-03 1984-04-19 C.H. Boehringer Sohn, 6507 Ingelheim 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
GB1595412A (en) * 1976-12-14 1981-08-12 Boots Co Ltd Method for control of pests attacking animals
US4094964A (en) * 1977-05-10 1978-06-13 Hoffmann-La Roche Inc. Clonidine assay
DE2806811A1 (de) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben
DE2806775A1 (de) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
ZA792696B (en) * 1978-05-31 1980-06-25 Boots Co Ltd Compounds,compositions and methods for controlling pests
US4262005A (en) * 1978-05-31 1981-04-14 The Boots Company Limited Compounds, compositions and methods for controlling pests
DE2831657A1 (de) * 1978-07-19 1980-02-07 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2832310A1 (de) * 1978-07-22 1980-02-07 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2905883A1 (de) * 1979-02-16 1980-08-28 Boehringer Sohn Ingelheim Radioimmuntest fuer clonidin
DE2947563A1 (de) * 1979-11-26 1981-06-04 C.H. Boehringer Sohn, 6507 Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2949287A1 (de) * 1979-12-07 1981-06-11 C.H. Boehringer Sohn, 6507 Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2950345A1 (de) * 1979-12-14 1981-07-02 C.H. Boehringer Sohn, 6507 Ingelheim Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE3168754D1 (en) * 1980-07-09 1985-03-21 Beecham Group Plc Clonidine derivatives useful in the treatment of diarrhoea

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56147773A (en) * 1980-03-03 1981-11-16 Merck & Co Inc Non-ovulation chicken feed composition
JPS57181060A (en) * 1981-04-24 1982-11-08 Beecham Group Ltd Imidazole derivatives, manufacture and medicinal composition containing them

Also Published As

Publication number Publication date
JPH0545584B2 (enExample) 1993-07-09
EP0081923B1 (en) 1987-01-21
EP0081923A2 (en) 1983-06-22
US4461904A (en) 1984-07-24
CA1183545A (en) 1985-03-05
DE3275184D1 (de) 1987-02-26
EP0081923A3 (en) 1983-07-20
ATE25079T1 (de) 1987-02-15

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