ATE25079T1 - 2-(trisubstituierte phenyl-imino)-imidazoline. - Google Patents
2-(trisubstituierte phenyl-imino)-imidazoline.Info
- Publication number
- ATE25079T1 ATE25079T1 AT82306187T AT82306187T ATE25079T1 AT E25079 T1 ATE25079 T1 AT E25079T1 AT 82306187 T AT82306187 T AT 82306187T AT 82306187 T AT82306187 T AT 82306187T AT E25079 T1 ATE25079 T1 AT E25079T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazoline
- imino
- tri
- substitute phenyl
- substitute
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/323,371 US4461904A (en) | 1981-11-20 | 1981-11-20 | 2-(Trisubstituted phenylimino)-imidazolines |
EP82306187A EP0081923B1 (de) | 1981-11-20 | 1982-11-19 | 2-(Trisubstituierte Phenyl-imino)-Imidazoline |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE25079T1 true ATE25079T1 (de) | 1987-02-15 |
Family
ID=23258934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT82306187T ATE25079T1 (de) | 1981-11-20 | 1982-11-19 | 2-(trisubstituierte phenyl-imino)-imidazoline. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4461904A (de) |
EP (1) | EP0081923B1 (de) |
JP (1) | JPS58109473A (de) |
AT (1) | ATE25079T1 (de) |
CA (1) | CA1183545A (de) |
DE (1) | DE3275184D1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3321282A1 (de) * | 1983-06-13 | 1984-12-13 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue 1-acetonyl-2-(phenylimino)-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
US4505926A (en) * | 1983-09-15 | 1985-03-19 | Beecham Group P.L.C. | Quaternary amino imidazolidines, compositions and use |
EP0236636A3 (de) * | 1986-02-07 | 1988-12-07 | Alcon Laboratories, Inc. | Verwendung von Clonidinderivaten zur Herstellung von okularen Hämostasemitteln |
US4587257A (en) * | 1984-12-14 | 1986-05-06 | Alcon Laboratories, Inc. | Control of ocular bleeding using clonidine derivatives |
AU585309B2 (en) * | 1984-12-14 | 1989-06-15 | Alcon Laboratories, Inc. | Method for controlling ocular bleeding |
FR2592042B1 (fr) * | 1985-12-19 | 1988-03-25 | Ile De France | Nouveaux ortho-anisamides, leur procede d'obtention, et leurs applications therapeutiques |
US5212196A (en) * | 1986-10-21 | 1993-05-18 | Alcon Laboratories, Inc. | Control of post-surgical intraocular pressure using clonidine derivatives |
US4801617A (en) * | 1987-04-06 | 1989-01-31 | Leclerc Gerard | Iminoimidazolidines useful in lowering intraocular pressure |
US4897412A (en) * | 1987-04-06 | 1990-01-30 | Laboratories Alcon S.A. | Imidazolines useful in lowering intraocular pressure |
CA1334168C (en) * | 1988-04-26 | 1995-01-31 | Louis M. De Santis | Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers |
GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
US5124154A (en) * | 1990-06-12 | 1992-06-23 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
JP3002258B2 (ja) * | 1992-10-13 | 2000-01-24 | アルコン ラボラトリーズ, インコーポレイテッド | 緑内障(glaucoma)治療のための、プロスタグランジンとクロニジン誘導体の組合わせ |
US5340572A (en) * | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
US5523316A (en) * | 1994-06-23 | 1996-06-04 | Alcon Laboratories, Inc. | Intraocular irrigating solution containing agent for controlling IOP |
DE19514579A1 (de) | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
US6602897B2 (en) * | 2000-10-14 | 2003-08-05 | Boehringer Ingelheim Pharma Kg | m-Amino-phenylimino-imidazolidine derivatives for treating urinary incontinence |
US7678829B2 (en) * | 2004-05-25 | 2010-03-16 | Qlt Inc. | Oculoselective drugs and prodrugs |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2938038A (en) * | 1960-05-24 | X-dihydroxyphenylamino | ||
US3236857A (en) * | 1961-10-09 | 1966-02-22 | Boehringer Sohn Ingelheim | 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products |
US3636219A (en) * | 1964-03-02 | 1972-01-18 | Du Pont | Anticholinergic compositions containing certain thiazolines or imidazolines |
DE1670274A1 (de) * | 1966-10-31 | 1970-07-16 | Boehringer Sohn Ingelheim | Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2) |
AT285599B (de) * | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen |
US3622579A (en) * | 1969-08-28 | 1971-11-23 | Boehringer Sohn Ingelheim | Derivatives of 2-anilino-1,3-diazacyclopentene-(2) |
BE759125A (fr) * | 1969-11-19 | 1971-05-18 | Boehringer Sohn Ingelheim | Nouvelles n-allyl-2-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer |
BE759126A (fr) * | 1969-11-19 | 1971-05-18 | Boehringer Sohn Ingelheim | Nouvelles n-cycloalcoyl-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer |
DE2220906A1 (de) * | 1972-04-28 | 1973-11-15 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung |
DE2316377C3 (de) * | 1973-04-02 | 1978-11-02 | Lentia Gmbh, Chem. U. Pharm. Erzeugnisse - Industriebedarf, 8000 Muenchen | Verfahren zur Herstellung von 2-Phenyl-amino-2-imidazolin-Derivaten und von deren Salzen |
US4125620A (en) * | 1974-10-01 | 1978-11-14 | Boehringer Ingelheim Gmbh | 2-[(2',6'-Disubstituted-phenyl)-imino]-imidazolidines and salts thereof |
DE2630060C2 (de) * | 1976-07-03 | 1984-04-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
GB1595412A (en) * | 1976-12-14 | 1981-08-12 | Boots Co Ltd | Method for control of pests attacking animals |
US4094964A (en) * | 1977-05-10 | 1978-06-13 | Hoffmann-La Roche Inc. | Clonidine assay |
DE2806775A1 (de) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
DE2806811A1 (de) * | 1978-02-17 | 1979-08-23 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben |
ZA792696B (en) * | 1978-05-31 | 1980-06-25 | Boots Co Ltd | Compounds,compositions and methods for controlling pests |
US4262005A (en) * | 1978-05-31 | 1981-04-14 | The Boots Company Limited | Compounds, compositions and methods for controlling pests |
DE2831657A1 (de) * | 1978-07-19 | 1980-02-07 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
DE2832310A1 (de) * | 1978-07-22 | 1980-02-07 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
DE2905883A1 (de) * | 1979-02-16 | 1980-08-28 | Boehringer Sohn Ingelheim | Radioimmuntest fuer clonidin |
DE2947563A1 (de) * | 1979-11-26 | 1981-06-04 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
DE2949287A1 (de) * | 1979-12-07 | 1981-06-11 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
DE2950345A1 (de) * | 1979-12-14 | 1981-07-02 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
US4287201A (en) * | 1980-03-03 | 1981-09-01 | Merck & Co., Inc. | Anovulatory method and chicken feed compositions |
EP0043659B1 (de) * | 1980-07-09 | 1985-02-06 | Beecham Group Plc | Bei der Behandlung der Diarrhöe verwendbare Clonidin-Derivate |
EP0070084A3 (de) * | 1981-04-24 | 1983-02-16 | Beecham Group Plc | Imidazolin-Derivate |
-
1981
- 1981-11-20 US US06/323,371 patent/US4461904A/en not_active Expired - Lifetime
-
1982
- 1982-11-12 CA CA000415421A patent/CA1183545A/en not_active Expired
- 1982-11-19 AT AT82306187T patent/ATE25079T1/de active
- 1982-11-19 DE DE8282306187T patent/DE3275184D1/de not_active Expired
- 1982-11-19 EP EP82306187A patent/EP0081923B1/de not_active Expired
- 1982-11-20 JP JP57204429A patent/JPS58109473A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
EP0081923B1 (de) | 1987-01-21 |
JPH0545584B2 (de) | 1993-07-09 |
CA1183545A (en) | 1985-03-05 |
DE3275184D1 (de) | 1987-02-26 |
US4461904A (en) | 1984-07-24 |
EP0081923A2 (de) | 1983-06-22 |
EP0081923A3 (en) | 1983-07-20 |
JPS58109473A (ja) | 1983-06-29 |
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