ES8201565A1 - Metodo perfeccionado para la fabricacion de 2-(3,4,5-trime- toxifenil),4,5-disubstituidos - Google Patents

Metodo perfeccionado para la fabricacion de 2-(3,4,5-trime- toxifenil),4,5-disubstituidos

Info

Publication number
ES8201565A1
ES8201565A1 ES500076A ES500076A ES8201565A1 ES 8201565 A1 ES8201565 A1 ES 8201565A1 ES 500076 A ES500076 A ES 500076A ES 500076 A ES500076 A ES 500076A ES 8201565 A1 ES8201565 A1 ES 8201565A1
Authority
ES
Spain
Prior art keywords
trimethoxyphenyl
disubstituted thiazoles
thiazoles
disubstituted
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500076A
Other languages
English (en)
Other versions
ES500076A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8705579A external-priority patent/JPS5612377A/ja
Priority claimed from JP6850780A external-priority patent/JPS56164175A/ja
Application filed by Kureha Corp filed Critical Kureha Corp
Publication of ES500076A0 publication Critical patent/ES500076A0/es
Publication of ES8201565A1 publication Critical patent/ES8201565A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-(3,4,5-TRIMETOXIFENIL)-TIAZOLES, 4,5-DISUSTITUIDOS, DE FORMULA (I) EN LA QUE R1 ES UN RADICAL ALQUILO C1-3; Y R2 ES UN GRUPO HIDROXILO, AMINO O HIDRACINO. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1 TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN COMPUESTO QUE PUEDE SER HIDROXIDO SODICO, AMONIACO O HIDRATO DE HIDRACINA. LA REACCION SE LLEVA A CABO EN METANOL O ETANOL COMO DISOLVENTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 50 C Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INGREDIENTES ACTIVOS EN MEDICINA ANTIULCERA PEPTICA.
ES500076A 1979-07-09 1981-02-13 Metodo perfeccionado para la fabricacion de 2-(3,4,5-trime- toxifenil),4,5-disubstituidos Expired ES8201565A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8705579A JPS5612377A (en) 1979-07-09 1979-07-09 Novel thiazole derivative, its preparation, and drug for ulcer having andigestive action
JP6850780A JPS56164175A (en) 1980-05-23 1980-05-23 Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent

Publications (2)

Publication Number Publication Date
ES500076A0 ES500076A0 (es) 1982-01-01
ES8201565A1 true ES8201565A1 (es) 1982-01-01

Family

ID=26409723

Family Applications (2)

Application Number Title Priority Date Filing Date
ES493650A Expired ES8105987A1 (es) 1979-07-09 1980-07-09 Procedimiento para la fabricacion de 2(3,4,5-trimetoxifenil)tiazoles,4,5-disubstituidos
ES500076A Expired ES8201565A1 (es) 1979-07-09 1981-02-13 Metodo perfeccionado para la fabricacion de 2-(3,4,5-trime- toxifenil),4,5-disubstituidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES493650A Expired ES8105987A1 (es) 1979-07-09 1980-07-09 Procedimiento para la fabricacion de 2(3,4,5-trimetoxifenil)tiazoles,4,5-disubstituidos

Country Status (7)

Country Link
US (1) US4363813A (es)
CA (1) CA1150272A (es)
DE (1) DE3026054C2 (es)
ES (2) ES8105987A1 (es)
FR (1) FR2465729A1 (es)
GB (1) GB2056440B (es)
IT (1) IT1131682B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5772975A (en) * 1980-10-24 1982-05-07 Kureha Chem Ind Co Ltd 2-substituted phenylthiazole derviative, and medicine for peptic ulcer containing said derivative as active component
DE3425118A1 (de) * 1984-07-07 1986-01-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue redox-indikatoren
US4746669A (en) * 1985-12-23 1988-05-24 Merck & Co., Inc. Substituted thiazoles as immunoregulants
FR2625199B1 (fr) * 1987-12-23 1991-03-22 Irceba Derives oxyimino du thiazole, procede de preparation et utilisation en therapeutique
CA2073981C (en) * 1990-11-30 2002-01-08 Shiro Kondo 2-arylthiazole derivatives and pharmaceutical composition thereof
WO1993024472A1 (en) * 1992-05-29 1993-12-09 Otsuka Pharmaceutical Co., Ltd. Thiazole derivative
US5639770A (en) * 1992-05-29 1997-06-17 Otsuka Pharmaceutical Co., Ltd. Thiazole derivatives
EP1577289A1 (en) * 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
EP1764096A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
EP1764094A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel multi-cyclic compounds and their use
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP1764093A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1743083A (en) * 1928-02-03 1930-01-07 Winthrop Chem Co Catechol thiazoles and process of making the same
US1970656A (en) * 1931-11-04 1934-08-21 Winthrop Chem Co Inc Thiazole compound and process of producing the same
US2014498A (en) * 1932-08-18 1935-09-17 Winthrop Chem Co Inc Halogenated derivatives of thiazole and process of preparing the same
US2030373A (en) * 1932-08-18 1936-02-11 Winthrop Chem Co Inc Derivatives of thiazole and process of preparing the same
US4154947A (en) * 1978-03-13 1979-05-15 American Cyanamid Company Heterocyclic substituted benzylideneaminoguanidines

Also Published As

Publication number Publication date
ES493650A0 (es) 1981-07-01
GB2056440B (en) 1983-05-25
IT8023315A0 (it) 1980-07-08
ES500076A0 (es) 1982-01-01
CA1150272A (en) 1983-07-19
ES8105987A1 (es) 1981-07-01
IT1131682B (it) 1986-06-25
US4363813A (en) 1982-12-14
GB2056440A (en) 1981-03-18
DE3026054C2 (de) 1982-03-11
FR2465729A1 (fr) 1981-03-27
FR2465729B1 (es) 1983-03-18
DE3026054A1 (de) 1981-02-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603