JPS56164175A - Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent - Google Patents

Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent

Info

Publication number
JPS56164175A
JPS56164175A JP6850780A JP6850780A JPS56164175A JP S56164175 A JPS56164175 A JP S56164175A JP 6850780 A JP6850780 A JP 6850780A JP 6850780 A JP6850780 A JP 6850780A JP S56164175 A JPS56164175 A JP S56164175A
Authority
JP
Japan
Prior art keywords
formula
compound
agent
thiazole derivative
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6850780A
Other languages
Japanese (ja)
Other versions
JPS6310950B2 (en
Inventor
Takao Kawasaki
Yoshiaki Osaka
Tadashi Tsuchiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Priority to JP6850780A priority Critical patent/JPS56164175A/en
Priority to US06/163,507 priority patent/US4363813A/en
Priority to CA000355635A priority patent/CA1150272A/en
Priority to FR8015210A priority patent/FR2465729A1/en
Priority to IT23315/80A priority patent/IT1131682B/en
Priority to GB8022292A priority patent/GB2056440B/en
Priority to DE3026054A priority patent/DE3026054C2/en
Priority to ES493650A priority patent/ES8105987A1/en
Priority to ES500076A priority patent/ES8201565A1/en
Publication of JPS56164175A publication Critical patent/JPS56164175A/en
Priority to CA000417020A priority patent/CA1158247A/en
Publication of JPS6310950B2 publication Critical patent/JPS6310950B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 2-(3,4,5-trimethoxyphenyl)-thiazole derivative of formula I (R1 is H or 1W3C alkyl; R2 is H, 1W3C alkyl, carboxyl or ester, amide, etc. thereof or oxime or semicarbazone derivative, etc. of the carbonyl in the acetyl group).
EXAMPLE: 2-(3,4,5-Trimethoxyphenyl)-4-methyl-5-acethylthiazoleoxime.
USE: An antipeptic ulcer agent, inhibitor against gastric acid, secretion, peripheral vasodilator and bronchodilator agent, hypotensive agent, antiarrhythmic agent and anti-inflammatory agent.
PROCESS: The aimed substance is obtained by the following methods: A compound of formula II is reacted with a compound of formula III (X is halogen) in an inert solvent at 50W150°C for 1W10hr to give the aimed substance. Alternatively, a compound of formula IV is reacted with a compound of the formula R1-NH2 to afford a compound of formula V (R2 is OH, NHCONH2, etc.).
COPYRIGHT: (C)1981,JPO&Japio
JP6850780A 1979-07-09 1980-05-23 Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent Granted JPS56164175A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP6850780A JPS56164175A (en) 1980-05-23 1980-05-23 Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent
US06/163,507 US4363813A (en) 1979-07-09 1980-06-27 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles
CA000355635A CA1150272A (en) 1979-07-09 1980-07-07 2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles
GB8022292A GB2056440B (en) 1979-07-09 1980-07-08 2 - (3,4,5 - trimethoxyphenyl)thiazoles
IT23315/80A IT1131682B (en) 1979-07-09 1980-07-08 2- (3,4,5-TRIMETOXYPHENYL) -TIAZOLI 4,5-BISUBSTITUTES AND PROCEDURE FOR THEIR PREPARATION
FR8015210A FR2465729A1 (en) 1979-07-09 1980-07-08 SUBSTITUTED 2- (3,4,5-TRIMETHOXYPHENYL) -THIAZOLES, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE
DE3026054A DE3026054C2 (en) 1979-07-09 1980-07-09 4,5-disubstituted 2- (3,4,5-trimethoxyphenyl) thiazoles and agents containing the same
ES493650A ES8105987A1 (en) 1979-07-09 1980-07-09 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles
ES500076A ES8201565A1 (en) 1979-07-09 1981-02-13 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles
CA000417020A CA1158247A (en) 1979-07-09 1982-12-03 2,(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6850780A JPS56164175A (en) 1980-05-23 1980-05-23 Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent

Publications (2)

Publication Number Publication Date
JPS56164175A true JPS56164175A (en) 1981-12-17
JPS6310950B2 JPS6310950B2 (en) 1988-03-10

Family

ID=13375681

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6850780A Granted JPS56164175A (en) 1979-07-09 1980-05-23 Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent

Country Status (1)

Country Link
JP (1) JPS56164175A (en)

Also Published As

Publication number Publication date
JPS6310950B2 (en) 1988-03-10

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