JPS56164175A - Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent - Google Patents
Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituentInfo
- Publication number
- JPS56164175A JPS56164175A JP6850780A JP6850780A JPS56164175A JP S56164175 A JPS56164175 A JP S56164175A JP 6850780 A JP6850780 A JP 6850780A JP 6850780 A JP6850780 A JP 6850780A JP S56164175 A JPS56164175 A JP S56164175A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- agent
- thiazole derivative
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2-(3,4,5-trimethoxyphenyl)-thiazole derivative of formula I (R1 is H or 1W3C alkyl; R2 is H, 1W3C alkyl, carboxyl or ester, amide, etc. thereof or oxime or semicarbazone derivative, etc. of the carbonyl in the acetyl group).
EXAMPLE: 2-(3,4,5-Trimethoxyphenyl)-4-methyl-5-acethylthiazoleoxime.
USE: An antipeptic ulcer agent, inhibitor against gastric acid, secretion, peripheral vasodilator and bronchodilator agent, hypotensive agent, antiarrhythmic agent and anti-inflammatory agent.
PROCESS: The aimed substance is obtained by the following methods: A compound of formula II is reacted with a compound of formula III (X is halogen) in an inert solvent at 50W150°C for 1W10hr to give the aimed substance. Alternatively, a compound of formula IV is reacted with a compound of the formula R1-NH2 to afford a compound of formula V (R2 is OH, NHCONH2, etc.).
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6850780A JPS56164175A (en) | 1980-05-23 | 1980-05-23 | Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent |
US06/163,507 US4363813A (en) | 1979-07-09 | 1980-06-27 | 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles |
CA000355635A CA1150272A (en) | 1979-07-09 | 1980-07-07 | 2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles |
GB8022292A GB2056440B (en) | 1979-07-09 | 1980-07-08 | 2 - (3,4,5 - trimethoxyphenyl)thiazoles |
IT23315/80A IT1131682B (en) | 1979-07-09 | 1980-07-08 | 2- (3,4,5-TRIMETOXYPHENYL) -TIAZOLI 4,5-BISUBSTITUTES AND PROCEDURE FOR THEIR PREPARATION |
FR8015210A FR2465729A1 (en) | 1979-07-09 | 1980-07-08 | SUBSTITUTED 2- (3,4,5-TRIMETHOXYPHENYL) -THIAZOLES, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE |
DE3026054A DE3026054C2 (en) | 1979-07-09 | 1980-07-09 | 4,5-disubstituted 2- (3,4,5-trimethoxyphenyl) thiazoles and agents containing the same |
ES493650A ES8105987A1 (en) | 1979-07-09 | 1980-07-09 | 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles |
ES500076A ES8201565A1 (en) | 1979-07-09 | 1981-02-13 | 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles |
CA000417020A CA1158247A (en) | 1979-07-09 | 1982-12-03 | 2,(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6850780A JPS56164175A (en) | 1980-05-23 | 1980-05-23 | Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56164175A true JPS56164175A (en) | 1981-12-17 |
JPS6310950B2 JPS6310950B2 (en) | 1988-03-10 |
Family
ID=13375681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6850780A Granted JPS56164175A (en) | 1979-07-09 | 1980-05-23 | Novel thiazole derivative and antipeptic ulcer agent containing the same as active constituent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56164175A (en) |
-
1980
- 1980-05-23 JP JP6850780A patent/JPS56164175A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6310950B2 (en) | 1988-03-10 |
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