JPS5777651A

JPS5777651A - Indane derivative and its preparation

Indane derivative and its preparation

Info

Publication number: JPS5777651A
Authority: JP; Japan
Prior art keywords: compound; formulai; lower alkyl; reducing conditions; indane derivative
Prior art date: 1980-10-31
Legal status : Granted

Application number

JP55154394A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6212800B2 (enrdf_load_stackoverflow

Inventor

Yoshikazu Oka

Kohei Nishikawa

Akio Miyake

Current Assignee

Takeda Pharmaceutical Co Ltd

Original Assignee

Takeda Chemical Industries Ltd

Priority date

1980-10-31

Filing date

1980-10-31

Publication date

1982-05-15

1980-10-31 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1980-10-31 Priority to JP55154394A priority Critical patent/JPS5777651A/ja

1981-10-16 Priority to AU76521/81A priority patent/AU543804B2/en

1981-10-19 Priority to US06/312,639 priority patent/US4822818A/en

1981-10-20 Priority to ZA817253A priority patent/ZA817253B/xx

1981-10-21 Priority to IE2471/81A priority patent/IE51918B1/en

1981-10-21 Priority to DE8181304940T priority patent/DE3165862D1/de

1981-10-21 Priority to EP81304940A priority patent/EP0051391B1/en

1981-10-21 Priority to GB8131719A priority patent/GB2086393B/en

1981-10-21 Priority to AT81304940T priority patent/ATE9220T1/de

1981-10-28 Priority to FI813383A priority patent/FI73698C/fi

1981-10-28 Priority to PH26409A priority patent/PH18357A/en

1981-10-29 Priority to SU813350151A priority patent/SU1271372A3/ru

1981-10-29 Priority to DK478181A priority patent/DK164917C/da

1981-10-29 Priority to NO813662A priority patent/NO155133C/no

1981-10-29 Priority to HU813176A priority patent/HU183652B/hu

1981-10-29 Priority to KR1019810004142A priority patent/KR880000890B1/ko

1981-10-29 Priority to MX7586A priority patent/MX154997A/es

1981-10-29 Priority to GR66380A priority patent/GR75368B/el

1981-10-29 Priority to CA000389042A priority patent/CA1287444C/en

1981-10-30 Priority to IL64168A priority patent/IL64168A0/xx

1981-10-30 Priority to PT73912A priority patent/PT73912B/pt

1981-10-30 Priority to ES506714A priority patent/ES506714A0/es

1981-10-30 Priority to NZ198826A priority patent/NZ198826A/en

1982-05-15 Publication of JPS5777651A publication Critical patent/JPS5777651A/ja

1982-08-26 Priority to ES515269A priority patent/ES515269A0/es

1983-05-12 Priority to US06/494,061 priority patent/US4474692A/en

1983-07-15 Priority to ES524148A priority patent/ES8504671A1/es

1983-10-12 Priority to PH29829A priority patent/PH21390A/en

1984-11-19 Priority to CA000468185A priority patent/CA1287446C/en

1985-12-30 Priority to MY500/85A priority patent/MY8500500A/xx

1986-07-15 Priority to NO862859A priority patent/NO157103C/no

1986-10-29 Priority to KR1019860009085A priority patent/KR880001007B1/ko

1987-03-05 Priority to HK198/87A priority patent/HK19887A/xx

1987-03-20 Publication of JPS6212800B2 publication Critical patent/JPS6212800B2/ja

1987-05-22 Priority to MX661087A priority patent/MX6610A/es

1989-01-30 Priority to US07/302,940 priority patent/US5098892A/en

Status Granted legal-status Critical Current

Links

125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 title 1
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
101800004538 Bradykinin Proteins 0.000 abstract 1
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
102100035792 Kininogen-1 Human genes 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229940039227 diagnostic agent Drugs 0.000 abstract 1
239000000032 diagnostic agent Substances 0.000 abstract 1
229960001269 glycine hydrochloride Drugs 0.000 abstract 1
-1 hydride compound Chemical class 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
150000002468 indanes Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1