JPS5770814A - Oral preparation of blood clotting eighth factor - Google Patents
Oral preparation of blood clotting eighth factorInfo
- Publication number
- JPS5770814A JPS5770814A JP55144508A JP14450880A JPS5770814A JP S5770814 A JPS5770814 A JP S5770814A JP 55144508 A JP55144508 A JP 55144508A JP 14450880 A JP14450880 A JP 14450880A JP S5770814 A JPS5770814 A JP S5770814A
- Authority
- JP
- Japan
- Prior art keywords
- factor
- ribosome
- blood clotting
- oral preparation
- enclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000023555 blood coagulation Effects 0.000 title abstract 3
- 239000002775 capsule Substances 0.000 abstract 2
- 108010039627 Aprotinin Proteins 0.000 abstract 1
- 208000031220 Hemophilia Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 229940122618 Trypsin inhibitor Drugs 0.000 abstract 1
- 101710162629 Trypsin inhibitor Proteins 0.000 abstract 1
- 229960004405 aprotinin Drugs 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
- 239000002753 trypsin inhibitor Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55144508A JPS5770814A (en) | 1980-10-17 | 1980-10-17 | Oral preparation of blood clotting eighth factor |
| GB8130122A GB2085729B (en) | 1980-10-17 | 1981-10-06 | Pharmaceutical composition for oral administration containing coagulation factor viii |
| US06/309,269 US4348384A (en) | 1980-10-17 | 1981-10-07 | Pharmaceutical composition for oral administration containing coagulation factor VIII or IX |
| DE19813141223 DE3141223A1 (de) | 1980-10-17 | 1981-10-16 | "oral verabreichbare arzneimittel zur therapie und prophylaxe von haemophilie a" |
| FR8119522A FR2492260A1 (fr) | 1980-10-17 | 1981-10-16 | Composition pharmaceutique pour l'administration orale contenant le facteur de coagulation viii |
| ES506320A ES506320A0 (es) | 1980-10-17 | 1981-10-16 | Un procedimiento para la preparacion de liposomas con el factor de coagulacion viii y un enhibidor de proteasa. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55144508A JPS5770814A (en) | 1980-10-17 | 1980-10-17 | Oral preparation of blood clotting eighth factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5770814A true JPS5770814A (en) | 1982-05-01 |
| JPH03366B2 JPH03366B2 (enrdf_load_stackoverflow) | 1991-01-07 |
Family
ID=15363986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55144508A Granted JPS5770814A (en) | 1980-10-17 | 1980-10-17 | Oral preparation of blood clotting eighth factor |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5770814A (enrdf_load_stackoverflow) |
| DE (1) | DE3141223A1 (enrdf_load_stackoverflow) |
| ES (1) | ES506320A0 (enrdf_load_stackoverflow) |
| FR (1) | FR2492260A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2085729B (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6056918A (ja) * | 1983-08-03 | 1985-04-02 | ビオメデイカ・フオスカマ・インデユストリア・キミコ−フアルマチエウテイカ・エツセ・ピ・ア | フルクト−ス−１，６−２燐酸含有リポソ−ム |
| JPS6069027A (ja) * | 1983-06-27 | 1985-04-19 | クイ−ンズ ユニバ−シテイ アツト キングストン | 止血用薬剤組成物 |
| JPS6150912A (ja) * | 1984-08-16 | 1986-03-13 | Shionogi & Co Ltd | リポソ−ム製剤の製造法 |
| JP2001514209A (ja) * | 1997-09-04 | 2001-09-11 | バイオゾーン ラボラトリーズ，インコーポレイテッド | 経口リポソーム送達系 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2581543B1 (fr) * | 1985-05-09 | 1989-07-07 | Tressens Dominique | Pharmacotechnie permettant la realisation d'une preparation insulinique active par voie orale |
| DE3625090A1 (de) * | 1986-07-24 | 1988-01-28 | Behringwerke Ag | Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung |
| GB8822857D0 (en) * | 1988-09-29 | 1988-11-02 | Patralan Ltd | Pharmaceutical formulations |
| GB9007052D0 (en) * | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
| DE4115453A1 (de) * | 1991-05-11 | 1992-11-12 | Knoll Ag | Neue wirkstoffkombination |
| WO1994028876A1 (en) * | 1993-06-07 | 1994-12-22 | Advanced Therapies, Inc. | Liposome powders |
| FR2706302B1 (fr) * | 1993-06-18 | 1995-08-18 | Franche Comte Universite | Produit alcalinisant sous forme gastro-résistante. |
| DE4416180C2 (de) * | 1994-05-06 | 1997-08-14 | Immuno Ag | Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen und Verfahren zur Herstellung dieses Präparats |
| US6017891A (en) * | 1994-05-06 | 2000-01-25 | Baxter Aktiengesellschaft | Stable preparation for the treatment of blood coagulation disorders |
| DE4416166C2 (de) * | 1994-05-06 | 1997-11-20 | Immuno Ag | Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen |
| CH689139A5 (de) * | 1995-04-03 | 1998-10-30 | Cerbios Pharma Sa | Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung. |
| PT2193809E (pt) | 1999-02-22 | 2015-08-24 | Baxter Int | Formulações de fator viii livres de albumina |
| EP2385825B1 (en) | 2008-11-07 | 2018-10-10 | University of Connecticut | Factor viii formulations |
| DE102009001334B4 (de) | 2009-03-04 | 2017-02-23 | Stefan Brosig | Einfache magensaftresistente Verkapselung, z.B. von Ingwer und anderen empfindlichen Stoffen |
| CN109316599A (zh) * | 2018-08-24 | 2019-02-12 | 上海交通大学医学院附属瑞金医院 | 一种抑肽酶或其突变体、衍生物、类似物或其组成片段的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2249552A1 (de) * | 1971-10-12 | 1973-05-30 | Inchema S A | Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen |
| NL7900459A (nl) * | 1979-01-19 | 1980-07-22 | Hendrik Coenraad Hemker Prof D | Farmaceutisch preparaat en werkwijze ter bereiding daarvan. |
-
1980
- 1980-10-17 JP JP55144508A patent/JPS5770814A/ja active Granted
-
1981
- 1981-10-06 GB GB8130122A patent/GB2085729B/en not_active Expired
- 1981-10-16 FR FR8119522A patent/FR2492260A1/fr active Granted
- 1981-10-16 ES ES506320A patent/ES506320A0/es active Granted
- 1981-10-16 DE DE19813141223 patent/DE3141223A1/de not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6069027A (ja) * | 1983-06-27 | 1985-04-19 | クイ−ンズ ユニバ−シテイ アツト キングストン | 止血用薬剤組成物 |
| JPS6056918A (ja) * | 1983-08-03 | 1985-04-02 | ビオメデイカ・フオスカマ・インデユストリア・キミコ−フアルマチエウテイカ・エツセ・ピ・ア | フルクト−ス−１，６−２燐酸含有リポソ−ム |
| JPS6150912A (ja) * | 1984-08-16 | 1986-03-13 | Shionogi & Co Ltd | リポソ−ム製剤の製造法 |
| JP2001514209A (ja) * | 1997-09-04 | 2001-09-11 | バイオゾーン ラボラトリーズ，インコーポレイテッド | 経口リポソーム送達系 |
| JP2010001317A (ja) * | 1997-09-04 | 2010-01-07 | Biozone Lab Inc | 経口リポソーム送達系 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03366B2 (enrdf_load_stackoverflow) | 1991-01-07 |
| ES8306323A1 (es) | 1983-05-16 |
| GB2085729B (en) | 1984-04-18 |
| GB2085729A (en) | 1982-05-06 |
| ES506320A0 (es) | 1983-05-16 |
| DE3141223A1 (de) | 1982-06-24 |
| FR2492260B1 (enrdf_load_stackoverflow) | 1984-07-27 |
| FR2492260A1 (fr) | 1982-04-23 |
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