JPS5750960A - Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone - Google Patents
Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenoneInfo
- Publication number
- JPS5750960A JPS5750960A JP12752580A JP12752580A JPS5750960A JP S5750960 A JPS5750960 A JP S5750960A JP 12752580 A JP12752580 A JP 12752580A JP 12752580 A JP12752580 A JP 12752580A JP S5750960 A JPS5750960 A JP S5750960A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- agent
- reaction
- isoindolinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Natural products CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- GPRYKVSEZCQIHD-UHFFFAOYSA-N 1-(4-aminophenyl)ethanone Chemical compound CC(=O)C1=CC=C(N)C=C1 GPRYKVSEZCQIHD-UHFFFAOYSA-N 0.000 abstract 2
- 239000000730 antalgic agent Substances 0.000 abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- JKNKNWJNCOJPLI-UHFFFAOYSA-N o-phthalaldehydic acid Chemical compound C1=CC=C2C(O)OC(=O)C2=C1 JKNKNWJNCOJPLI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- RJMIEHBSYVWVIN-LLVKDONJSA-N (2r)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]propanoic acid Chemical compound C1=CC([C@H](C(O)=O)C)=CC=C1N1C(=O)C2=CC=CC=C2C1 RJMIEHBSYVWVIN-LLVKDONJSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229960004187 indoprofen Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12752580A JPS5750960A (en) | 1980-09-10 | 1980-09-10 | Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12752580A JPS5750960A (en) | 1980-09-10 | 1980-09-10 | Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5750960A true JPS5750960A (en) | 1982-03-25 |
| JPS632260B2 JPS632260B2 (enrdf_load_stackoverflow) | 1988-01-18 |
Family
ID=14962166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12752580A Granted JPS5750960A (en) | 1980-09-10 | 1980-09-10 | Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5750960A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009530306A (ja) * | 2006-03-17 | 2009-08-27 | アメリカ合衆国 | 脊髄性筋萎縮症の治療およびその他用途のための化合物 |
-
1980
- 1980-09-10 JP JP12752580A patent/JPS5750960A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009530306A (ja) * | 2006-03-17 | 2009-08-27 | アメリカ合衆国 | 脊髄性筋萎縮症の治療およびその他用途のための化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS632260B2 (enrdf_load_stackoverflow) | 1988-01-18 |
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