JPS5748984A - Pyrid 2,3-d pyrimidine-6-glyoxylic derivative and its salt - Google Patents
Pyrid 2,3-d pyrimidine-6-glyoxylic derivative and its saltInfo
- Publication number
- JPS5748984A JPS5748984A JP55125587A JP12558780A JPS5748984A JP S5748984 A JPS5748984 A JP S5748984A JP 55125587 A JP55125587 A JP 55125587A JP 12558780 A JP12558780 A JP 12558780A JP S5748984 A JPS5748984 A JP S5748984A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pyrimidine
- glyoxylic
- pyrid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- -1 2-( 4-Acetyl-1-piperazinyl )-8-ethyl-5,8-dihydro-5-oxopyrido[ 2,3-d ] pyrimidine-6-glyoxylic acid Chemical compound 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
NEW MATERIAL:A Compound of formula I (R1 is H, lower alkanoyl; R2 is lower alkyl; R3 is H, alkyl) and their salts.
EXAMPLE: 2-( 4-Acetyl-1-piperazinyl )-8-ethyl-5,8-dihydro-5-oxopyrido[ 2,3-d ] pyrimidine-6-glyoxylic acid.
USE: Antibiotics and synthetic intermediates of other antibiotics.
PREPARATION: A compound of formula II (R'1 is lower alkanoyl; R4 is lower alyl) is heated in a high-boiling solvent such as biphenyl at 140W260°C to effect cyclization to form a compound of formula III, which is made to react with an alkylating agent to produce a compound of formula IV. Then, selenium dioxide is made to act on the product in a solvent such as pyridine at 60W110°C to give a compound of formula I'. The compound of formula I' can be converted into other compounds of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55125587A JPS5748984A (en) | 1980-09-09 | 1980-09-09 | Pyrid 2,3-d pyrimidine-6-glyoxylic derivative and its salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55125587A JPS5748984A (en) | 1980-09-09 | 1980-09-09 | Pyrid 2,3-d pyrimidine-6-glyoxylic derivative and its salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5748984A true JPS5748984A (en) | 1982-03-20 |
| JPH0115513B2 JPH0115513B2 (en) | 1989-03-17 |
Family
ID=14913861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55125587A Granted JPS5748984A (en) | 1980-09-09 | 1980-09-09 | Pyrid 2,3-d pyrimidine-6-glyoxylic derivative and its salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5748984A (en) |
-
1980
- 1980-09-09 JP JP55125587A patent/JPS5748984A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0115513B2 (en) | 1989-03-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS56131565A (en) | 4-substituted-2-oxoazetidine compound and its preparation | |
| JPS5748984A (en) | Pyrid 2,3-d pyrimidine-6-glyoxylic derivative and its salt | |
| JPS5738759A (en) | Preparation of novel aromatic carboxylic acid derivative | |
| JPS56118083A (en) | Furo(3,2-b)(1,8)naphthyridine derivative | |
| JPS56125386A (en) | Pyrido (2,3-d)pyrimidine derivative and its preparation | |
| JPS5759897A (en) | Thiazolineazatidinone | |
| JPS5690067A (en) | Novel heterocyclic ring substituted phenylacetic acid derivative | |
| JPS5620577A (en) | 4- n-alkylanilino quinazoline derivative and its preparation | |
| JPS57146772A (en) | 3,3-di-substituted indolidin-2-one compound and its preparation | |
| JPS5527142A (en) | Novel 1-phthalazone derivative | |
| JPS5484597A (en) | Novel heterocyclic compound and its preparation | |
| JPS5646873A (en) | 2-guanidinothiazole derivative and its preparation | |
| JPS55120591A (en) | Phosphinoethylmalonic acid derivative, and preparation thereof | |
| JPS5639074A (en) | Pyrimidine derivative | |
| JPS55104266A (en) | Novel pyridone derivative | |
| JPS54128599A (en) | Pyrrolobenzazepin derivative | |
| JPS55139388A (en) | Cephalosporin derivative | |
| JPS54135788A (en) | Tricyclic compound and its preparation | |
| JPS5538361A (en) | 6-hydroxymethylpyrido 2,3-d pyrimidine derivative and its preparation | |
| JPS5549386A (en) | Heterocyclic compound and its acid addition salt | |
| JPS57145867A (en) | Novel 6-oxabicyclo(3,2,1)octane-7-one derivative | |
| JPS5716885A (en) | 3,4-benzo-7-thia-2-azabicyclo 3,3,1 nonane derivative | |
| JPS5721348A (en) | 2- 1-methyl-2-propenyl -3-hydroxyundecanoic derivative | |
| JPS57116048A (en) | Novel quinoline derivative | |
| JPS5785391A (en) | Thieno(3,4-alpha)imidazoline derivative and its preparation |