JPS56118083A - Furo(3,2-b)(1,8)naphthyridine derivative - Google Patents

Furo(3,2-b)(1,8)naphthyridine derivative

Info

Publication number
JPS56118083A
JPS56118083A JP2144180A JP2144180A JPS56118083A JP S56118083 A JPS56118083 A JP S56118083A JP 2144180 A JP2144180 A JP 2144180A JP 2144180 A JP2144180 A JP 2144180A JP S56118083 A JPS56118083 A JP S56118083A
Authority
JP
Japan
Prior art keywords
formula
compound
acid
lower alkyl
naphthyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2144180A
Other languages
Japanese (ja)
Other versions
JPS6221798B2 (en
Inventor
Yoshiaki Tanaka
Isao Hayakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP2144180A priority Critical patent/JPS56118083A/en
Publication of JPS56118083A publication Critical patent/JPS56118083A/en
Publication of JPS6221798B2 publication Critical patent/JPS6221798B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:5,8-Dihydrofuro- or 2,3,5,8-tetrahydrofuro[3,2-b][1,8]naphthyridine-7-carboxylic acid derivative of formula Ia and IIb, or their salts.
EXAMPLE: 5-( 2-Fluoroethyl )-5,8-dihydro-8-oxofuro[ 3,2-b ][ 1,8 ]naphthyridine-7- boxylic acid.
USE: Fungicide.
PROCESS: The compound of formula Ia is prepared by (1) reacting a compound of formula II (R1 is lower alkyl; R2 is H, lower alkyloxy, etc.) with 1-bromo-2-fluoroethane in the presence of an acid scavenger such as potassium carbonate, (2) heating the resulting compound of formula III together with N,N-dialkylformamide diethyl acetal in the presence of a dialkylamine to obtain a compound of formula IV (R3 is lower alkyl), (3) heating the compound in an alcohol in the presence of hydrobromic acid, etc., and (4) reacting the resulting compound of formula V (R4 is lower alkyl) with concentrated sulfuric acid and hydrobromic acid, etc.
COPYRIGHT: (C)1981,JPO&Japio
JP2144180A 1980-02-22 1980-02-22 Furo(3,2-b)(1,8)naphthyridine derivative Granted JPS56118083A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2144180A JPS56118083A (en) 1980-02-22 1980-02-22 Furo(3,2-b)(1,8)naphthyridine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2144180A JPS56118083A (en) 1980-02-22 1980-02-22 Furo(3,2-b)(1,8)naphthyridine derivative

Publications (2)

Publication Number Publication Date
JPS56118083A true JPS56118083A (en) 1981-09-16
JPS6221798B2 JPS6221798B2 (en) 1987-05-14

Family

ID=12055045

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2144180A Granted JPS56118083A (en) 1980-02-22 1980-02-22 Furo(3,2-b)(1,8)naphthyridine derivative

Country Status (1)

Country Link
JP (1) JPS56118083A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008046135A1 (en) * 2006-10-16 2008-04-24 Bionomics Limited Novel anxiolytic compounds
US9023848B2 (en) 2011-03-02 2015-05-05 Bionomics Limited Small-molecules as therapeutics
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008046135A1 (en) * 2006-10-16 2008-04-24 Bionomics Limited Novel anxiolytic compounds
US8293737B2 (en) 2006-10-16 2012-10-23 Bionomics Limited Anxiolytic compounds
US8551990B2 (en) 2006-10-16 2013-10-08 Bionomics Limited Anxiolytic compounds
US8614212B2 (en) 2006-10-16 2013-12-24 Bionomics Limited Anxiolytic compounds
US8906912B2 (en) 2006-10-16 2014-12-09 Bionomics Limited Anxiolytic compounds
US9573945B2 (en) 2006-10-16 2017-02-21 Bionomics Limited Anxiolytic compounds
JP2017105818A (en) * 2006-10-16 2017-06-15 バイオノミクス リミテッド Novel anxiolytic compounds
US9975892B2 (en) 2006-10-16 2018-05-22 Bionomics Limited Anxiolytic compounds
US10233181B2 (en) 2006-10-16 2019-03-19 Bionomics Limited Anxiolytic compounds
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
US9023848B2 (en) 2011-03-02 2015-05-05 Bionomics Limited Small-molecules as therapeutics
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines

Also Published As

Publication number Publication date
JPS6221798B2 (en) 1987-05-14

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