JPS5731930A - Production of cytotoxic substance-bound reactive polymer - Google Patents
Production of cytotoxic substance-bound reactive polymerInfo
- Publication number
- JPS5731930A JPS5731930A JP10637680A JP10637680A JPS5731930A JP S5731930 A JPS5731930 A JP S5731930A JP 10637680 A JP10637680 A JP 10637680A JP 10637680 A JP10637680 A JP 10637680A JP S5731930 A JPS5731930 A JP S5731930A
- Authority
- JP
- Japan
- Prior art keywords
- reactive polymer
- cytotoxic substance
- amino
- group
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To produce titled polymer useful as an antitumoric agent, by reacting a specified reactive polymer with a cytotoxic substance containing an amino or imino group in the molecule.
CONSTITUTION: A reactive polymer, polymerization degree 5W3,000, consisting of at least 60mol% structural units of formula I, wherein Z is H or a monovalent cation and m is 1W4, and having, on the carboxyl terminal groups of its main chains, active goups of formula II, wherein X is H or a group capable of forming an active disulfide group together with the S atom, W is a bivalent organic group and R1 is H or a 1W4C alkyl, is reacted with a cytotoxic substance containing an amino or imino group in the molecule, e.g., mitomycin C, in an organic solvent at -40W100°C for 10minW10days to obtain a reactive polymer, polymerization degree 5W3,000, consisting of at least 60mol% structural units of formulas I and III, wherein Y is the amino or imino residue of a cytotoxic substance and m is 1W4, and containing active groups of formula II on the carboxyl groups of the main chains.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10637680A JPS5731930A (en) | 1980-08-04 | 1980-08-04 | Production of cytotoxic substance-bound reactive polymer |
DE8181302118T DE3175151D1 (en) | 1980-05-21 | 1981-05-13 | Reactive polymer and process for the preparation thereof |
EP81302118A EP0040506B1 (en) | 1980-05-21 | 1981-05-13 | Reactive polymer and process for the preparation thereof |
US06/265,924 US4385169A (en) | 1980-05-21 | 1981-05-21 | Reactive alpha amino acid polymer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10637680A JPS5731930A (en) | 1980-08-04 | 1980-08-04 | Production of cytotoxic substance-bound reactive polymer |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5731930A true JPS5731930A (en) | 1982-02-20 |
JPS6219770B2 JPS6219770B2 (en) | 1987-05-01 |
Family
ID=14431989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10637680A Granted JPS5731930A (en) | 1980-05-21 | 1980-08-04 | Production of cytotoxic substance-bound reactive polymer |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5731930A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59116232A (en) * | 1982-12-24 | 1984-07-05 | Teijin Ltd | Cell toxicity complex and its preparation |
JPS59159827A (en) * | 1983-03-02 | 1984-09-10 | Teijin Ltd | Reactive polymer having bonded cytotoxic substance and its production |
JPS62275128A (en) * | 1986-02-14 | 1987-11-30 | Nippon Mejifuijitsukusu Kk | Reactive high-molecular compound having amino group and bifunctional ligand and use thereof |
JPS63302909A (en) * | 1987-06-01 | 1988-12-09 | Kurita Mach Mfg Co Ltd | Filter press |
-
1980
- 1980-08-04 JP JP10637680A patent/JPS5731930A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59116232A (en) * | 1982-12-24 | 1984-07-05 | Teijin Ltd | Cell toxicity complex and its preparation |
JPH048411B2 (en) * | 1982-12-24 | 1992-02-17 | ||
JPS59159827A (en) * | 1983-03-02 | 1984-09-10 | Teijin Ltd | Reactive polymer having bonded cytotoxic substance and its production |
JPH0149298B2 (en) * | 1983-03-02 | 1989-10-24 | Teijin Ltd | |
JPS62275128A (en) * | 1986-02-14 | 1987-11-30 | Nippon Mejifuijitsukusu Kk | Reactive high-molecular compound having amino group and bifunctional ligand and use thereof |
JPS63302909A (en) * | 1987-06-01 | 1988-12-09 | Kurita Mach Mfg Co Ltd | Filter press |
JPH0367722B2 (en) * | 1987-06-01 | 1991-10-24 | Kurita Machinery Manuf |
Also Published As
Publication number | Publication date |
---|---|
JPS6219770B2 (en) | 1987-05-01 |
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