JPS5726690A - New preparation of cephamycin derivative - Google Patents

New preparation of cephamycin derivative

Info

Publication number
JPS5726690A
JPS5726690A JP10060380A JP10060380A JPS5726690A JP S5726690 A JPS5726690 A JP S5726690A JP 10060380 A JP10060380 A JP 10060380A JP 10060380 A JP10060380 A JP 10060380A JP S5726690 A JPS5726690 A JP S5726690A
Authority
JP
Japan
Prior art keywords
protecting group
give
formula
compound
carboxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10060380A
Other languages
Japanese (ja)
Inventor
Toshinori Saito
Shunzo Fukatsu
Takeshi Nishihata
Masayuki Shibahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP10060380A priority Critical patent/JPS5726690A/en
Publication of JPS5726690A publication Critical patent/JPS5726690A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an antimicrobial agent, etc. in high yield, by treating a specific amide group-containing cephem carboxylic acid with a halogenating agent, followed by imino etherification with a lower alcohol, treatment with an acylating agent, and removal of protecting group.
CONSTITUTION: A compound shown by the formula I (R1 is amino-protecting group; R2 is H or amino-protecting group; R3 and R4 are carboxyl-protecting group) is treated with a halogenating agent in the presence of a base to give an imino halide derivative, which is reacted with a lower alcohol to give an imino ether derivative shown by the formula II (R5 is lower alkyl). This compound is reacted with an acylating agent to give a compound shown by the formula III [R6 is X2CH (X2 is halogen), etc.], the carboxyl-protecting group R4 is removed and the resulting compound is reacted with cysteine, etc., to give 7β-(2D-2-amino-2-carboxyl) eth ethyl-thioacetamido-7α-methoxy-3-( 1-methyl-1H-tetrazole-5-yl )thiomethyl-3-cephem-4-carboxylic acid shown by the formula IV or its salt.
COPYRIGHT: (C)1982,JPO&Japio
JP10060380A 1980-07-24 1980-07-24 New preparation of cephamycin derivative Pending JPS5726690A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10060380A JPS5726690A (en) 1980-07-24 1980-07-24 New preparation of cephamycin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10060380A JPS5726690A (en) 1980-07-24 1980-07-24 New preparation of cephamycin derivative

Publications (1)

Publication Number Publication Date
JPS5726690A true JPS5726690A (en) 1982-02-12

Family

ID=14278432

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10060380A Pending JPS5726690A (en) 1980-07-24 1980-07-24 New preparation of cephamycin derivative

Country Status (1)

Country Link
JP (1) JPS5726690A (en)

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