JPS57188589A - 3(4-phenyl-1-piperazino-1-yl)-1,2-propanediol- 3-(theophyllin-7-yl)-1-propane sulfonate, manufacture and antitussive medicine containing same - Google Patents

3(4-phenyl-1-piperazino-1-yl)-1,2-propanediol- 3-(theophyllin-7-yl)-1-propane sulfonate, manufacture and antitussive medicine containing same

Info

Publication number
JPS57188589A
JPS57188589A JP57027570A JP2757082A JPS57188589A JP S57188589 A JPS57188589 A JP S57188589A JP 57027570 A JP57027570 A JP 57027570A JP 2757082 A JP2757082 A JP 2757082A JP S57188589 A JPS57188589 A JP S57188589A
Authority
JP
Japan
Prior art keywords
theophyllin
piperazino
propanediol
phenyl
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57027570A
Other languages
English (en)
Other versions
JPH0333715B2 (ja
Inventor
Pesuterini Bitsutorio
Gerarudoni Mario
Gianotsuchi Daniro
Meri Aruberuto
Aruberutoo Matsugi Karuro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EI MENARINII ESU EI ESU
Menarini SAS
Original Assignee
EI MENARINII ESU EI ESU
Menarini SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI MENARINII ESU EI ESU, Menarini SAS filed Critical EI MENARINII ESU EI ESU
Publication of JPS57188589A publication Critical patent/JPS57188589A/ja
Publication of JPH0333715B2 publication Critical patent/JPH0333715B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP57027570A 1981-02-25 1982-02-24 3(4-phenyl-1-piperazino-1-yl)-1,2-propanediol- 3-(theophyllin-7-yl)-1-propane sulfonate, manufacture and antitussive medicine containing same Granted JPS57188589A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8109343A IT1210639B (it) 1981-02-25 1981-02-25 Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione

Publications (2)

Publication Number Publication Date
JPS57188589A true JPS57188589A (en) 1982-11-19
JPH0333715B2 JPH0333715B2 (ja) 1991-05-20

Family

ID=11128724

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57027570A Granted JPS57188589A (en) 1981-02-25 1982-02-24 3(4-phenyl-1-piperazino-1-yl)-1,2-propanediol- 3-(theophyllin-7-yl)-1-propane sulfonate, manufacture and antitussive medicine containing same

Country Status (18)

Country Link
US (1) US4372958A (ja)
JP (1) JPS57188589A (ja)
AT (1) AT380881B (ja)
BE (1) BE892271A (ja)
CA (1) CA1192549A (ja)
CH (1) CH651043A5 (ja)
DE (1) DE3205149A1 (ja)
DK (1) DK148687C (ja)
ES (1) ES8302680A1 (ja)
FR (1) FR2500455A1 (ja)
GB (1) GB2093445B (ja)
GR (1) GR76060B (ja)
IT (1) IT1210639B (ja)
LU (1) LU83962A1 (ja)
NL (1) NL8200746A (ja)
PT (1) PT74463B (ja)
SE (1) SE440503B (ja)
YU (1) YU44007B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004505074A (ja) * 2000-07-28 2004-02-19 ドムペ・ソチエタ・ペル・アツィオーニ 鎮咳剤としての２，２−二置換１，３−ジオキソラン

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
IT1217950B (it) * 1988-06-28 1990-03-30 Dott Formenti Ind Chimica E Fa Sali di (r,s) 3 (4 fenil 1 piperazinil) 1,2 propandtolo
IT1231158B (it) * 1989-07-20 1991-11-19 Dompe Farmaceutici Spa Procedimento per la risoluzione ottica della dropropizina.
DE3938123A1 (de) * 1989-11-16 1991-05-23 Diehl Gmbh & Co Treibladungsanzuender

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3163649A (en) * 1964-12-29 Substituteb phenyl-piperazine
GB938646A (en) * 1961-03-16 1963-10-02 Henri Morren New piperazine derivatives
FR1384693A (fr) * 1963-10-08 1965-01-08 Electrochimie Soc Procédé de préparation d'esters méthallyliques
FR1554628A (ja) * 1967-05-23 1969-01-24

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004505074A (ja) * 2000-07-28 2004-02-19 ドムペ・ソチエタ・ペル・アツィオーニ 鎮咳剤としての２，２−二置換１，３−ジオキソラン

Also Published As

Publication number Publication date
DK148687B (da) 1985-09-02
YU44007B (en) 1990-02-28
PT74463A (en) 1982-03-01
IT1210639B (it) 1989-09-14
IT8109343A0 (it) 1981-02-25
BE892271A (fr) 1982-06-16
DE3205149C2 (ja) 1991-04-18
ES509850A0 (es) 1983-02-01
US4372958A (en) 1983-02-08
CA1192549A (en) 1985-08-27
SE8201184L (sv) 1982-08-26
PT74463B (en) 1983-08-24
SE440503B (sv) 1985-08-05
FR2500455B1 (ja) 1984-04-27
YU41282A (en) 1987-10-31
GR76060B (ja) 1984-08-03
ATA59982A (de) 1985-12-15
FR2500455A1 (fr) 1982-08-27
DK148687C (da) 1986-04-28
CH651043A5 (it) 1985-08-30
GB2093445B (en) 1985-02-27
DE3205149A1 (de) 1982-11-11
LU83962A1 (fr) 1982-07-08
JPH0333715B2 (ja) 1991-05-20
ES8302680A1 (es) 1983-02-01
AT380881B (de) 1986-07-25
GB2093445A (en) 1982-09-02
DK79982A (da) 1982-08-26
NL8200746A (nl) 1982-09-16

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