JPS57140783A - 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same - Google Patents

1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Info

Publication number
JPS57140783A
JPS57140783A JP56015837A JP1583781A JPS57140783A JP S57140783 A JPS57140783 A JP S57140783A JP 56015837 A JP56015837 A JP 56015837A JP 1583781 A JP1583781 A JP 1583781A JP S57140783 A JPS57140783 A JP S57140783A
Authority
JP
Japan
Prior art keywords
benzyl
compound
salt
formula
dioxopiperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56015837A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6366319B2 (xx
Inventor
Takako Hori
Chosaku Yoshida
Yasuo Kiba
Takatsune Takeno
Joji Nakano
Jun Nitta
Sumiko Kishimoto
Shohachi Murakami
Hisatsugu Tsuda
Isamu Saikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP56015837A priority Critical patent/JPS57140783A/ja
Priority to US06/345,055 priority patent/US4459407A/en
Priority to CH674/82A priority patent/CH651036A5/de
Priority to ES509391A priority patent/ES509391A0/es
Priority to SE8200679A priority patent/SE449101B/sv
Priority to FR8201925A priority patent/FR2499569A1/fr
Priority to GB8203333A priority patent/GB2094296B/en
Priority to IT8247729A priority patent/IT1154274B/it
Priority to NL8200451A priority patent/NL8200451A/nl
Priority to BE0/207239A priority patent/BE892032A/fr
Priority to AU80240/82A priority patent/AU537512B2/en
Priority to KR8200513A priority patent/KR880001105B1/ko
Priority to DE19823204074 priority patent/DE3204074A1/de
Publication of JPS57140783A publication Critical patent/JPS57140783A/ja
Priority to ES518304A priority patent/ES518304A0/es
Publication of JPS6366319B2 publication Critical patent/JPS6366319B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
JP56015837A 1979-07-24 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same Granted JPS57140783A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP56015837A JPS57140783A (en) 1981-02-06 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same
US06/345,055 US4459407A (en) 1979-07-24 1982-02-02 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives and salts thereof
CH674/82A CH651036A5 (de) 1981-02-06 1982-02-04 1-benzyl-4-(4-(2-pyrimidinylamino)-benzyl)-2,3-dioxopiperazin-derivate, salze derselben, verfahren zur herstellung derselben und carcinostatische mittel mit einem gehalt derselben.
IT8247729A IT1154274B (it) 1981-02-06 1982-02-05 Derivati di piperazina, procedimento per produrli ed agenti carcinostatici che li contengono
AU80240/82A AU537512B2 (en) 1981-02-06 1982-02-05 Dioxopiperazine derivatives
FR8201925A FR2499569A1 (fr) 1981-02-06 1982-02-05 Nouveaux derives de 1-benzyl- 4-(4-(2-pyrimidinylamino)benzyl)-2,3- dioxopiperazines, leurs sels, un procede de preparation de ces derives et sels et un agent carcinostatique les contenant
GB8203333A GB2094296B (en) 1981-02-06 1982-02-05 Dioxopiperazine derivatives
ES509391A ES509391A0 (es) 1981-02-06 1982-02-05 Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4(4-(2-pirimidinilamino)bencil-2,3-dioxopiperazina o sus sales.
NL8200451A NL8200451A (nl) 1981-02-06 1982-02-05 1-benzyl-4-4-(2-pyrimidinylamino)benzyl-2,3-dioxopiperazinederivaten, zouten daarvan en werkwijzen voor het bereiden van deze derivaten en van farmaceutische preparaten die ze bevatten.
BE0/207239A BE892032A (fr) 1981-02-06 1982-02-05 Nouveaux derives de 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl-2,3-dioxopiperazines, leurs sels, un procede de preparation de ces derives et sels et un agent carcinostatique les contenant
SE8200679A SE449101B (sv) 1981-02-06 1982-02-05 1-bensyl-4-/4-(2-pyrimidinylamino)bensyl/-2,3-dioxopiperazinderivat, forfarande for framstellning derav och karcinostatiska medel der de ingar
KR8200513A KR880001105B1 (ko) 1981-02-06 1982-02-06 1-벤질-4-[4-(2-피리미디닐아미노)벤질]-2,3-디옥소피페라진 유도체의 제조방법
DE19823204074 DE3204074A1 (de) 1981-02-06 1982-02-06 Neue 1-benzyl-4-(4-(2-pyrimidinylamino)-benzyl)-2,3-dioxopiperazin-derivate, salze derselben, verfahren zur herstellung derselben und carcinostatische mittel mit einem gehalt derselben
ES518304A ES518304A0 (es) 1981-02-06 1982-12-16 Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4-(4-(2-pirimidinilamino)bencil)-2,3-dioxopiperazina o sus sales.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56015837A JPS57140783A (en) 1981-02-06 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Publications (2)

Publication Number Publication Date
JPS57140783A true JPS57140783A (en) 1982-08-31
JPS6366319B2 JPS6366319B2 (xx) 1988-12-20

Family

ID=11899943

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56015837A Granted JPS57140783A (en) 1979-07-24 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Country Status (12)

Country Link
JP (1) JPS57140783A (xx)
KR (1) KR880001105B1 (xx)
AU (1) AU537512B2 (xx)
BE (1) BE892032A (xx)
CH (1) CH651036A5 (xx)
DE (1) DE3204074A1 (xx)
ES (2) ES509391A0 (xx)
FR (1) FR2499569A1 (xx)
GB (1) GB2094296B (xx)
IT (1) IT1154274B (xx)
NL (1) NL8200451A (xx)
SE (1) SE449101B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028257A1 (fr) * 1996-12-24 1998-07-02 Chugai Seiyaku Kabushiki Kaisha Derives d'amine aromatiques ayant une action inhibitrice a l'egard des nos

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7371622B2 (ja) * 2018-04-11 2023-10-31 三菱瓦斯化学株式会社 ジシアノアルカンおよびビス（アミノメチル）アルカンの製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618969A (en) * 1979-07-24 1981-02-23 Toyama Chem Co Ltd Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028257A1 (fr) * 1996-12-24 1998-07-02 Chugai Seiyaku Kabushiki Kaisha Derives d'amine aromatiques ayant une action inhibitrice a l'egard des nos

Also Published As

Publication number Publication date
ES8402285A1 (es) 1984-01-16
GB2094296A (en) 1982-09-15
IT8247729A0 (it) 1982-02-05
AU537512B2 (en) 1984-06-28
GB2094296B (en) 1985-02-13
DE3204074C2 (xx) 1987-12-23
KR830009090A (ko) 1983-12-17
IT1154274B (it) 1987-01-21
FR2499569B1 (xx) 1985-02-22
BE892032A (fr) 1982-08-05
DE3204074A1 (de) 1982-10-28
ES8304970A1 (es) 1983-03-16
KR880001105B1 (ko) 1988-06-29
NL8200451A (nl) 1982-09-01
AU8024082A (en) 1982-08-12
FR2499569A1 (fr) 1982-08-13
ES509391A0 (es) 1983-03-16
SE8200679L (sv) 1982-09-22
SE449101B (sv) 1987-04-06
JPS6366319B2 (xx) 1988-12-20
ES518304A0 (es) 1984-01-16
CH651036A5 (de) 1985-08-30

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