JPS5711988A - Esterification of epipenicilin oxide - Google Patents

Esterification of epipenicilin oxide

Info

Publication number
JPS5711988A
JPS5711988A JP8578880A JP8578880A JPS5711988A JP S5711988 A JPS5711988 A JP S5711988A JP 8578880 A JP8578880 A JP 8578880A JP 8578880 A JP8578880 A JP 8578880A JP S5711988 A JPS5711988 A JP S5711988A
Authority
JP
Japan
Prior art keywords
oxide
epipenicillin
epipenicilin
esterification
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8578880A
Other languages
Japanese (ja)
Inventor
Yoshitsuru Yoshioka
Wataru Nagata
Yoshinori Hamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP8578880A priority Critical patent/JPS5711988A/en
Publication of JPS5711988A publication Critical patent/JPS5711988A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain 6-epipenicillin ester-1-oxide useful as an intermediate for synthesizing a β-lactam antibiotic, by reacting 6-epipenicillin-1-oxide with an esterifying agent.
CONSTITUTION: 6-Epipenicillin-1-oxide, a penicillanic acid wherein it has acylamino at 6α position and S at 1 position is linked with O to form a sulfoxide is esterified to give 6-epipenicillin ester-1-oxide. For example, an alcohol to be introduced, its active derivative, etc, may be cited as the esterifying agent. The reaction is carried out in the presence of a condensation agent in an inert solvent at -50 to 60°C.
COPYRIGHT: (C)1982,JPO&Japio
JP8578880A 1980-06-23 1980-06-23 Esterification of epipenicilin oxide Pending JPS5711988A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8578880A JPS5711988A (en) 1980-06-23 1980-06-23 Esterification of epipenicilin oxide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8578880A JPS5711988A (en) 1980-06-23 1980-06-23 Esterification of epipenicilin oxide

Publications (1)

Publication Number Publication Date
JPS5711988A true JPS5711988A (en) 1982-01-21

Family

ID=13868619

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8578880A Pending JPS5711988A (en) 1980-06-23 1980-06-23 Esterification of epipenicilin oxide

Country Status (1)

Country Link
JP (1) JPS5711988A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60203773A (en) * 1984-03-27 1985-10-15 鈴鹿塗料株式会社 Reinforcement treatment of surface of inorganic substrate
JPS61117366A (en) * 1984-11-10 1986-06-04 日建株式会社 Repairing of surface of concrete
JPS62117957A (en) * 1985-11-14 1987-05-29 日東化学工業株式会社 Reparing of cementitious structure

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60203773A (en) * 1984-03-27 1985-10-15 鈴鹿塗料株式会社 Reinforcement treatment of surface of inorganic substrate
JPS61117366A (en) * 1984-11-10 1986-06-04 日建株式会社 Repairing of surface of concrete
JPS62117957A (en) * 1985-11-14 1987-05-29 日東化学工業株式会社 Reparing of cementitious structure
JPH0552394B2 (en) * 1985-11-14 1993-08-05 Nitto Chemical Industry Co Ltd

Similar Documents

Publication Publication Date Title
JPS543087A (en) Preparation of cephalosporin compound
JPS54119494A (en) Preparation of cephalosporin compound
JPS5711988A (en) Esterification of epipenicilin oxide
JPS5746988A (en) Novel penicillin derivative and its preparation
JPS55105658A (en) Manufacture of methyleneebiss*44phenylcarbamic ester*
GB1542709A (en) Process for the manufacture of polycarboxylic acid polyglycidyl esters
ES8101608A1 (en) Process for preparing 3-exomethylenecepham sulfoxides.
JPS55147284A (en) Novel beta-lactam derivative and its preparation
JPS5732290A (en) Novel penicillin derivative and its preparation
SU910599A1 (en) Process for producing diesters of glycols and trifluoroacetic acid
SE7908597L (en) SET TO MAKE KETOIC ACIDS AND ESTERS
IE44886L (en) Quinoline carboxylic acid esters
ES457577A1 (en) Esters of 7-sulfenyliminocephem-4-carboxylic acids
JPS53135996A (en) Preparation of cephalosporin compounds
JPS5610193A (en) Preparation of rifamycin derivative
JPS56135488A (en) Novel preparative method of cephalosporanic acid derivative
JPS53112868A (en) Production of thienylacetic acid derivative
JPS5461128A (en) Peptide derivative
JPS5515427A (en) Preparation of olefin oxide
JPS5398987A (en) Novel process for preparation of 7-amino-3-substitued thiomethylcephemcarboxylic acids
JPS53135998A (en) Preparation of 6 alpha-acylaminopenicillanic acid 1-oxide
JPS51115489A (en) Method for preparing antibiotics
JPS57109794A (en) Preparation of cephalosporin analog
JPS5572192A (en) 1-carba-2-penem-3-carboxylic acid derivative and its preparation
JPS5562091A (en) Preparation of penicillin derivative