JPS5711988A - Esterification of epipenicilin oxide - Google Patents
Esterification of epipenicilin oxideInfo
- Publication number
- JPS5711988A JPS5711988A JP8578880A JP8578880A JPS5711988A JP S5711988 A JPS5711988 A JP S5711988A JP 8578880 A JP8578880 A JP 8578880A JP 8578880 A JP8578880 A JP 8578880A JP S5711988 A JPS5711988 A JP S5711988A
- Authority
- JP
- Japan
- Prior art keywords
- oxide
- epipenicillin
- epipenicilin
- esterification
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain 6-epipenicillin ester-1-oxide useful as an intermediate for synthesizing a β-lactam antibiotic, by reacting 6-epipenicillin-1-oxide with an esterifying agent.
CONSTITUTION: 6-Epipenicillin-1-oxide, a penicillanic acid wherein it has acylamino at 6α position and S at 1 position is linked with O to form a sulfoxide is esterified to give 6-epipenicillin ester-1-oxide. For example, an alcohol to be introduced, its active derivative, etc, may be cited as the esterifying agent. The reaction is carried out in the presence of a condensation agent in an inert solvent at -50 to 60°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8578880A JPS5711988A (en) | 1980-06-23 | 1980-06-23 | Esterification of epipenicilin oxide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8578880A JPS5711988A (en) | 1980-06-23 | 1980-06-23 | Esterification of epipenicilin oxide |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5711988A true JPS5711988A (en) | 1982-01-21 |
Family
ID=13868619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8578880A Pending JPS5711988A (en) | 1980-06-23 | 1980-06-23 | Esterification of epipenicilin oxide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5711988A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60203773A (en) * | 1984-03-27 | 1985-10-15 | 鈴鹿塗料株式会社 | Reinforcement treatment of surface of inorganic substrate |
JPS61117366A (en) * | 1984-11-10 | 1986-06-04 | 日建株式会社 | Repairing of surface of concrete |
JPS62117957A (en) * | 1985-11-14 | 1987-05-29 | 日東化学工業株式会社 | Reparing of cementitious structure |
-
1980
- 1980-06-23 JP JP8578880A patent/JPS5711988A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60203773A (en) * | 1984-03-27 | 1985-10-15 | 鈴鹿塗料株式会社 | Reinforcement treatment of surface of inorganic substrate |
JPS61117366A (en) * | 1984-11-10 | 1986-06-04 | 日建株式会社 | Repairing of surface of concrete |
JPS62117957A (en) * | 1985-11-14 | 1987-05-29 | 日東化学工業株式会社 | Reparing of cementitious structure |
JPH0552394B2 (en) * | 1985-11-14 | 1993-08-05 | Nitto Chemical Industry Co Ltd |
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