JPS57109774A - 2-substituted benzfuran derivative, manufacture and medicinal composition containing same - Google Patents

2-substituted benzfuran derivative, manufacture and medicinal composition containing same

Info

Publication number
JPS57109774A
JPS57109774A JP56180430A JP18043081A JPS57109774A JP S57109774 A JPS57109774 A JP S57109774A JP 56180430 A JP56180430 A JP 56180430A JP 18043081 A JP18043081 A JP 18043081A JP S57109774 A JPS57109774 A JP S57109774A
Authority
JP
Japan
Prior art keywords
benzfuran
derivative
substituted
manufacture
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56180430A
Other languages
English (en)
Other versions
JPH0245629B2 (ja
Inventor
Pesuterini Bitsutorio
Chierarudoni Mario
Aruberutoo Magii Karuroo
Ronkutsuchi Kaburioo
Meri Aruberutoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EI MENARINII ESU AARU ESU
Original Assignee
EI MENARINII ESU AARU ESU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI MENARINII ESU AARU ESU filed Critical EI MENARINII ESU AARU ESU
Publication of JPS57109774A publication Critical patent/JPS57109774A/ja
Publication of JPH0245629B2 publication Critical patent/JPH0245629B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP56180430A 1980-11-12 1981-11-12 2-substituted benzfuran derivative, manufacture and medicinal composition containing same Granted JPS57109774A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT09583/80A IT1154888B (it) 1980-11-12 1980-11-12 Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione

Publications (2)

Publication Number Publication Date
JPS57109774A true JPS57109774A (en) 1982-07-08
JPH0245629B2 JPH0245629B2 (ja) 1990-10-11

Family

ID=11132470

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56180430A Granted JPS57109774A (en) 1980-11-12 1981-11-12 2-substituted benzfuran derivative, manufacture and medicinal composition containing same

Country Status (14)

Country Link
US (2) US4485112A (ja)
JP (1) JPS57109774A (ja)
BE (1) BE891092A (ja)
CA (1) CA1182454A (ja)
CH (1) CH653679A5 (ja)
DE (1) DE3145004A1 (ja)
DK (1) DK153788C (ja)
ES (1) ES507072A0 (ja)
FR (1) FR2493845B1 (ja)
GB (1) GB2091719B (ja)
GR (1) GR76933B (ja)
IT (1) IT1154888B (ja)
NL (1) NL8105121A (ja)
SE (1) SE451328B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001180A1 (en) * 1991-07-09 1993-01-21 Nippon Shinyaku Co., Ltd. Benzofuran derivative and pharmaceutical composition
JP2013537898A (ja) * 2010-09-27 2013-10-07 ビオポロジェ ヒスタミンｈ４受容体リガンドとしてのベンザゾール誘導体

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550091B1 (fr) * 1983-08-02 1986-05-23 Sanofi Sa Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne
CA1281325C (en) * 1984-06-20 1991-03-12 Patrice C. Belanger Benzofuran derivatives
US5087638A (en) * 1984-06-20 1992-02-11 Merck Frosst Canada, Inc. Benzofuran derivatives
IT1216256B (it) * 1986-08-13 1990-02-22 Menarini Sas (benzofuran-2-il) imidazoli, con attivita' farmacologica,loro sali e procedimenti di fabbricazione relativi.
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
US4806663A (en) * 1987-04-06 1989-02-21 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4831156A (en) * 1987-09-30 1989-05-16 The University Of Tennessee Research Corp. 3-substituted 2-alkyl indole derivatives
WO1989002893A1 (en) * 1987-09-30 1989-04-06 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzothiophene derivatives
US4975458A (en) * 1989-03-13 1990-12-04 Taro Pharmaceuticals Industries, Ltd. 2-alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
FR2708609B1 (fr) * 1993-07-29 1995-10-20 Sanofi Elf Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant.
US6653328B1 (en) * 1995-03-10 2003-11-25 Eli Lilly And Company 3-benzyl-benzothiophenes
US6417199B1 (en) * 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
WO2004026253A2 (en) * 2002-09-17 2004-04-01 Arqule, Inc. Novel lapacho compounds and methods of use thereof
US20210130312A1 (en) * 2018-04-03 2021-05-06 Children's Hospital Medical Center Inhibitors of eya3-protein tyrosine phosphatase in dna damage repair signaling of pulmonary arterial hypertension

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1160925A (en) * 1967-02-08 1969-08-06 Menarini Sas 2-Substituted Benzofuran Derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3156688A (en) * 1962-11-05 1964-11-10 Abbott Lab Nu-alkyl and nu-aralkyl benzoxacycloalkanemethylamines
DE1492403A1 (de) * 1965-03-30 1969-12-04 Merck Ag E UV-Lichtschutzmittel fuer kosmetische Zwecke
US3880891A (en) * 1973-09-21 1975-04-29 Smithkline Corp Substituted benzofurans
US4024273A (en) * 1974-06-20 1977-05-17 Smithkline Corporation Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
US3983245A (en) * 1975-02-06 1976-09-28 Smithkline Corporation Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1160925A (en) * 1967-02-08 1969-08-06 Menarini Sas 2-Substituted Benzofuran Derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001180A1 (en) * 1991-07-09 1993-01-21 Nippon Shinyaku Co., Ltd. Benzofuran derivative and pharmaceutical composition
JP2013537898A (ja) * 2010-09-27 2013-10-07 ビオポロジェ ヒスタミンｈ４受容体リガンドとしてのベンザゾール誘導体

Also Published As

Publication number Publication date
CA1182454A (en) 1985-02-12
IT1154888B (it) 1987-01-21
SE451328B (sv) 1987-09-28
ES8307781A1 (es) 1983-08-16
IT8009583A0 (it) 1980-11-12
JPH0245629B2 (ja) 1990-10-11
GB2091719B (en) 1985-06-05
ES507072A0 (es) 1983-08-16
DK153788B (da) 1988-09-05
CH653679A5 (it) 1986-01-15
DE3145004A1 (de) 1982-06-16
SE8106733L (sv) 1982-05-13
GB2091719A (en) 1982-08-04
BE891092A (fr) 1982-03-01
GR76933B (ja) 1984-09-04
NL8105121A (nl) 1982-06-01
FR2493845A1 (fr) 1982-05-14
DK153788C (da) 1989-01-23
DK501181A (da) 1982-05-13
US4604392A (en) 1986-08-05
FR2493845B1 (fr) 1985-07-05
US4485112A (en) 1984-11-27

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