JPS5692271A - Isoindoline derivative and its preparation - Google Patents
Isoindoline derivative and its preparationInfo
- Publication number
- JPS5692271A JPS5692271A JP16827379A JP16827379A JPS5692271A JP S5692271 A JPS5692271 A JP S5692271A JP 16827379 A JP16827379 A JP 16827379A JP 16827379 A JP16827379 A JP 16827379A JP S5692271 A JPS5692271 A JP S5692271A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- agent
- reducing
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:An isoindoline derivative expressed by formula I (R1 is H or halogen; R2 and R3 are lower alkyl or together with N form pyrrolidine, piperidine or morpholine ring).
EXAMPLE: 2-[4-(β-pyrrolidinoethoxy)phenyl]isoindolin-1-one.
USE: An analgesic agent, an anti-inflammatory agent and an antipyretic agent having improved pharmacological action.
PROCESS: A compound of formula II is refluxed with a compound of formula III in a solvent, e.g. water or ethanol, preferably in the presence of a base, e.g. sodium hydroxide, under heating to prepare the compound of formula I. For example, the raw material compound of formula II is obtained by reducing an N-substituted phenylphthalimide derivative of formula IV prepared by reacting phthalic anhydride with an aniline with a reducing agent, e.g. zinc- acetic acid.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16827379A JPS5692271A (en) | 1979-12-26 | 1979-12-26 | Isoindoline derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16827379A JPS5692271A (en) | 1979-12-26 | 1979-12-26 | Isoindoline derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5692271A true JPS5692271A (en) | 1981-07-25 |
Family
ID=15864954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16827379A Pending JPS5692271A (en) | 1979-12-26 | 1979-12-26 | Isoindoline derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5692271A (en) |
-
1979
- 1979-12-26 JP JP16827379A patent/JPS5692271A/en active Pending
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