JPS5692271A - Isoindoline derivative and its preparation - Google Patents

Isoindoline derivative and its preparation

Info

Publication number
JPS5692271A
JPS5692271A JP16827379A JP16827379A JPS5692271A JP S5692271 A JPS5692271 A JP S5692271A JP 16827379 A JP16827379 A JP 16827379A JP 16827379 A JP16827379 A JP 16827379A JP S5692271 A JPS5692271 A JP S5692271A
Authority
JP
Japan
Prior art keywords
formula
compound
agent
reducing
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16827379A
Other languages
Japanese (ja)
Inventor
Tsutomu Kameyama
Noboru Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP16827379A priority Critical patent/JPS5692271A/en
Publication of JPS5692271A publication Critical patent/JPS5692271A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:An isoindoline derivative expressed by formula I (R1 is H or halogen; R2 and R3 are lower alkyl or together with N form pyrrolidine, piperidine or morpholine ring).
EXAMPLE: 2-[4-(β-pyrrolidinoethoxy)phenyl]isoindolin-1-one.
USE: An analgesic agent, an anti-inflammatory agent and an antipyretic agent having improved pharmacological action.
PROCESS: A compound of formula II is refluxed with a compound of formula III in a solvent, e.g. water or ethanol, preferably in the presence of a base, e.g. sodium hydroxide, under heating to prepare the compound of formula I. For example, the raw material compound of formula II is obtained by reducing an N-substituted phenylphthalimide derivative of formula IV prepared by reacting phthalic anhydride with an aniline with a reducing agent, e.g. zinc- acetic acid.
COPYRIGHT: (C)1981,JPO&Japio
JP16827379A 1979-12-26 1979-12-26 Isoindoline derivative and its preparation Pending JPS5692271A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16827379A JPS5692271A (en) 1979-12-26 1979-12-26 Isoindoline derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16827379A JPS5692271A (en) 1979-12-26 1979-12-26 Isoindoline derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5692271A true JPS5692271A (en) 1981-07-25

Family

ID=15864954

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16827379A Pending JPS5692271A (en) 1979-12-26 1979-12-26 Isoindoline derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5692271A (en)

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