JPS55139370A - Preparation of 1,4-di-substituted piperazine - Google Patents
Preparation of 1,4-di-substituted piperazineInfo
- Publication number
- JPS55139370A JPS55139370A JP4427879A JP4427879A JPS55139370A JP S55139370 A JPS55139370 A JP S55139370A JP 4427879 A JP4427879 A JP 4427879A JP 4427879 A JP4427879 A JP 4427879A JP S55139370 A JPS55139370 A JP S55139370A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- halogen
- catalyst
- reacting
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound useful as an antitussive, etc., in high yield, with a simple and economical process, by reacting 1-(2-phenyl-2-alkoxyethyl)-4- (halomethyl)-piperazine, etc. with a propiophenone derivative.
CONSTITUTION: The compound III is prepared by reacting a compound I (R is H, or alkyl; X ia halogen or OH) with a compound II (R1 is H, halogen, alkyl or alkoxy), pref. in the presence of an organic solvent (e.g. alcohol, ether, aromatic hydrocarbon, etc.). The use of a reaction catalyst improves the yield of the compound III. The catalyst is either a basic catalyst (e.g. triethylamine) or a dehydration catalyst (e.g. dicyclohexylcarbodimide) depending upon whether the X of formula I is halogen or OH. The compound I is a novel compound, and can be prepared by reducing the reaction product of a compound IV and a halogenocarbonic acid alkyl ester.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4427879A JPS55139370A (en) | 1979-04-13 | 1979-04-13 | Preparation of 1,4-di-substituted piperazine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4427879A JPS55139370A (en) | 1979-04-13 | 1979-04-13 | Preparation of 1,4-di-substituted piperazine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55139370A true JPS55139370A (en) | 1980-10-31 |
Family
ID=12687033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4427879A Pending JPS55139370A (en) | 1979-04-13 | 1979-04-13 | Preparation of 1,4-di-substituted piperazine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55139370A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03227575A (en) * | 1990-09-14 | 1991-10-08 | Semiconductor Energy Lab Co Ltd | Photoelectric conversion device |
JPH05234473A (en) * | 1991-03-01 | 1993-09-10 | Toenec Corp | Switch with voltage detecting and phase detection lock function |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5188976A (en) * | 1975-02-04 | 1976-08-04 | ||
JPS5422379A (en) * | 1977-07-21 | 1979-02-20 | Asahi Chem Ind Co Ltd | Preparation of piperazine derivative |
-
1979
- 1979-04-13 JP JP4427879A patent/JPS55139370A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5188976A (en) * | 1975-02-04 | 1976-08-04 | ||
JPS5422379A (en) * | 1977-07-21 | 1979-02-20 | Asahi Chem Ind Co Ltd | Preparation of piperazine derivative |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03227575A (en) * | 1990-09-14 | 1991-10-08 | Semiconductor Energy Lab Co Ltd | Photoelectric conversion device |
JPH0558271B2 (en) * | 1990-09-14 | 1993-08-26 | Handotai Energy Kenkyusho | |
JPH05234473A (en) * | 1991-03-01 | 1993-09-10 | Toenec Corp | Switch with voltage detecting and phase detection lock function |
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