JPS568391A - Cephalosporin compound for oral use - Google Patents

Cephalosporin compound for oral use

Info

Publication number
JPS568391A
JPS568391A JP8421979A JP8421979A JPS568391A JP S568391 A JPS568391 A JP S568391A JP 8421979 A JP8421979 A JP 8421979A JP 8421979 A JP8421979 A JP 8421979A JP S568391 A JPS568391 A JP S568391A
Authority
JP
Japan
Prior art keywords
formula
compound
gram
protected
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8421979A
Other languages
Japanese (ja)
Inventor
Hideo Nakao
Shinichi Sugawara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP8421979A priority Critical patent/JPS568391A/en
Priority to IT8067851A priority patent/IT8067851A0/en
Priority to GB8017766A priority patent/GB2051066A/en
Priority to DE19803020625 priority patent/DE3020625A1/en
Priority to NL8003186A priority patent/NL8003186A/en
Priority to ES492045A priority patent/ES8105326A1/en
Priority to FR8012193A priority patent/FR2457870A1/en
Publication of JPS568391A publication Critical patent/JPS568391A/en
Priority to ES499081A priority patent/ES499081A0/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

NEW MATERIAL:7-[ 2-(2-Aminothiazol-4-yl)-2-hydroxyiminoacetamido ]-3-methyl-3-cephem-4-carboxylic acid pivaloyloxymethyl ester (syn-isomer) of formula I, and its salt.
USE: An antimicrobial, well absorbable by the digestive tract, administrable, orally, and rapidly decomposable in vivo to give a compound of formula II effective against a wide range of Gram-positive and Gram-negative bacteria at a high blood level.
PROCESS: A compound of formula III or its acid addition salt is reacted with a carboxylic acid of formula IV (R is NH2 or protected NH2; R' is OH or protected OH) or its reactive derivative in the presence of a solvent, e.g. acetone, at room temperature or under cooling, and if necessary subjected to deprotection, to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP8421979A 1979-06-01 1979-07-03 Cephalosporin compound for oral use Pending JPS568391A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP8421979A JPS568391A (en) 1979-07-03 1979-07-03 Cephalosporin compound for oral use
IT8067851A IT8067851A0 (en) 1979-06-01 1980-05-30 CEPHALOSPORIN DERIVATIVES ORAL STRABLE ADMINISTRATION AND PROCEDURE FOR THEIR PREPARATION
GB8017766A GB2051066A (en) 1979-06-01 1980-05-30 Cephalosporin derivatives suitable for oral administration
DE19803020625 DE3020625A1 (en) 1979-06-01 1980-05-30 CEPHALOSPORINE DERIVATIVES SUITABLE FOR ORAL ADMINISTRATION
NL8003186A NL8003186A (en) 1979-06-01 1980-05-30 CEPHALOSPORIN COMPOUNDS SUITABLE FOR ORAL ADMINISTRATION.
ES492045A ES8105326A1 (en) 1979-06-01 1980-05-30 Cephalosporin derivatives suitable for oral administration
FR8012193A FR2457870A1 (en) 1979-06-01 1980-06-02 ORAL ADMINISTRATIVE CEPHALOSPORIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
ES499081A ES499081A0 (en) 1979-06-01 1981-02-03 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF CEFALOSPORANIC ACI-DO

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8421979A JPS568391A (en) 1979-07-03 1979-07-03 Cephalosporin compound for oral use

Publications (1)

Publication Number Publication Date
JPS568391A true JPS568391A (en) 1981-01-28

Family

ID=13824362

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8421979A Pending JPS568391A (en) 1979-06-01 1979-07-03 Cephalosporin compound for oral use

Country Status (1)

Country Link
JP (1) JPS568391A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0273090A (en) * 1988-08-23 1990-03-13 Bristol Myers Co Novel production of cephem prodrug ester

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0273090A (en) * 1988-08-23 1990-03-13 Bristol Myers Co Novel production of cephem prodrug ester

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