JPS568391A - Cephalosporin compound for oral use - Google Patents
Cephalosporin compound for oral useInfo
- Publication number
- JPS568391A JPS568391A JP8421979A JP8421979A JPS568391A JP S568391 A JPS568391 A JP S568391A JP 8421979 A JP8421979 A JP 8421979A JP 8421979 A JP8421979 A JP 8421979A JP S568391 A JPS568391 A JP S568391A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- gram
- protected
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
NEW MATERIAL:7-[ 2-(2-Aminothiazol-4-yl)-2-hydroxyiminoacetamido ]-3-methyl-3-cephem-4-carboxylic acid pivaloyloxymethyl ester (syn-isomer) of formula I, and its salt.
USE: An antimicrobial, well absorbable by the digestive tract, administrable, orally, and rapidly decomposable in vivo to give a compound of formula II effective against a wide range of Gram-positive and Gram-negative bacteria at a high blood level.
PROCESS: A compound of formula III or its acid addition salt is reacted with a carboxylic acid of formula IV (R is NH2 or protected NH2; R' is OH or protected OH) or its reactive derivative in the presence of a solvent, e.g. acetone, at room temperature or under cooling, and if necessary subjected to deprotection, to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8421979A JPS568391A (en) | 1979-07-03 | 1979-07-03 | Cephalosporin compound for oral use |
IT8067851A IT8067851A0 (en) | 1979-06-01 | 1980-05-30 | CEPHALOSPORIN DERIVATIVES ORAL STRABLE ADMINISTRATION AND PROCEDURE FOR THEIR PREPARATION |
GB8017766A GB2051066A (en) | 1979-06-01 | 1980-05-30 | Cephalosporin derivatives suitable for oral administration |
DE19803020625 DE3020625A1 (en) | 1979-06-01 | 1980-05-30 | CEPHALOSPORINE DERIVATIVES SUITABLE FOR ORAL ADMINISTRATION |
NL8003186A NL8003186A (en) | 1979-06-01 | 1980-05-30 | CEPHALOSPORIN COMPOUNDS SUITABLE FOR ORAL ADMINISTRATION. |
ES492045A ES8105326A1 (en) | 1979-06-01 | 1980-05-30 | Cephalosporin derivatives suitable for oral administration |
FR8012193A FR2457870A1 (en) | 1979-06-01 | 1980-06-02 | ORAL ADMINISTRATIVE CEPHALOSPORIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATION |
ES499081A ES499081A0 (en) | 1979-06-01 | 1981-02-03 | A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF CEFALOSPORANIC ACI-DO |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8421979A JPS568391A (en) | 1979-07-03 | 1979-07-03 | Cephalosporin compound for oral use |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS568391A true JPS568391A (en) | 1981-01-28 |
Family
ID=13824362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8421979A Pending JPS568391A (en) | 1979-06-01 | 1979-07-03 | Cephalosporin compound for oral use |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS568391A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0273090A (en) * | 1988-08-23 | 1990-03-13 | Bristol Myers Co | Novel production of cephem prodrug ester |
-
1979
- 1979-07-03 JP JP8421979A patent/JPS568391A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0273090A (en) * | 1988-08-23 | 1990-03-13 | Bristol Myers Co | Novel production of cephem prodrug ester |
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