ES8105326A1 - Cephalosporin derivatives suitable for oral administration - Google Patents

Cephalosporin derivatives suitable for oral administration

Info

Publication number
ES8105326A1
ES8105326A1 ES492045A ES492045A ES8105326A1 ES 8105326 A1 ES8105326 A1 ES 8105326A1 ES 492045 A ES492045 A ES 492045A ES 492045 A ES492045 A ES 492045A ES 8105326 A1 ES8105326 A1 ES 8105326A1
Authority
ES
Spain
Prior art keywords
oral administration
derivatives suitable
cephalosporin derivatives
aminothiazol
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492045A
Other languages
Spanish (es)
Other versions
ES492045A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6829179A external-priority patent/JPS55160782A/en
Priority claimed from JP8421979A external-priority patent/JPS568391A/en
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8105326A1 publication Critical patent/ES8105326A1/en
Publication of ES492045A0 publication Critical patent/ES492045A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

C2-8alkanoyloxymethyl 7-[2-(2- aminothiazol-4-yl)-2-(hydroxy or methoxy)iminoacetamido]-3-methyl- 3-cephem-4-carboxylates (syn isomers) are readily absorbed through the digestive tract and converted in vivo to the corresponding carboxylic acids, which have outstanding antibiotic properties. These esters may be prepared by acylation of the corresponding acyloxymethyl 7- aminodesacetoxycephalosporanate, by esterification of the corresponding acid or by conversion of an undesired acyl group at the 7-position of a cephalosporin compound to the desired 7-[2-(2-aminothiazol-4-yl)-2- (hydroxy or methoxy)iminoacetyl] group.
ES492045A 1979-06-01 1980-05-30 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF CEFALOSPORANIC ACI-DO Granted ES492045A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6829179A JPS55160782A (en) 1979-06-01 1979-06-01 Cephalosporin compound for oral administration
JP8421979A JPS568391A (en) 1979-07-03 1979-07-03 Cephalosporin compound for oral use

Publications (2)

Publication Number Publication Date
ES8105326A1 true ES8105326A1 (en) 1981-05-16
ES492045A0 ES492045A0 (en) 1981-05-16

Family

ID=26409507

Family Applications (2)

Application Number Title Priority Date Filing Date
ES492045A Granted ES492045A0 (en) 1979-06-01 1980-05-30 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF CEFALOSPORANIC ACI-DO
ES499081A Expired ES8202559A1 (en) 1979-06-01 1981-02-03 Cephalosporin derivatives suitable for oral administration

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES499081A Expired ES8202559A1 (en) 1979-06-01 1981-02-03 Cephalosporin derivatives suitable for oral administration

Country Status (6)

Country Link
DE (1) DE3020625A1 (en)
ES (2) ES492045A0 (en)
FR (1) FR2457870A1 (en)
GB (1) GB2051066A (en)
IT (1) IT8067851A0 (en)
NL (1) NL8003186A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK379681A (en) * 1981-07-17 1983-01-18 Hoffmann La Roche METHOD OF PREPARING CEPHALOSPORIDE DERIVATIVES
EP0148007A3 (en) * 1983-12-26 1986-04-02 Yamanouchi Pharmaceutical Co. Ltd. Cephalosporin compounds and medicaments and their production
US4914091A (en) * 1984-04-02 1990-04-03 American Cyanamid Company Esters of cephalosporin derivitives
US4935508A (en) * 1988-08-23 1990-06-19 Bristol-Myers Company Process for cephem prodrug esters

Also Published As

Publication number Publication date
GB2051066A (en) 1981-01-14
NL8003186A (en) 1980-12-03
FR2457870A1 (en) 1980-12-26
DE3020625A1 (en) 1980-12-04
ES492045A0 (en) 1981-05-16
ES499081A0 (en) 1982-02-01
ES8202559A1 (en) 1982-02-01
IT8067851A0 (en) 1980-05-30

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