ES8202559A1 - Cephalosporin derivatives suitable for oral administration - Google Patents

Cephalosporin derivatives suitable for oral administration

Info

Publication number
ES8202559A1
ES8202559A1 ES499081A ES499081A ES8202559A1 ES 8202559 A1 ES8202559 A1 ES 8202559A1 ES 499081 A ES499081 A ES 499081A ES 499081 A ES499081 A ES 499081A ES 8202559 A1 ES8202559 A1 ES 8202559A1
Authority
ES
Spain
Prior art keywords
oral administration
derivatives suitable
cephalosporin derivatives
aminothiazol
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499081A
Other languages
Spanish (es)
Other versions
ES499081A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6829179A external-priority patent/JPS55160782A/en
Priority claimed from JP8421979A external-priority patent/JPS568391A/en
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES499081A0 publication Critical patent/ES499081A0/en
Publication of ES8202559A1 publication Critical patent/ES8202559A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

C2-8alkanoyloxymethyl 7-[2-(2- aminothiazol-4-yl)-2-(hydroxy or methoxy)iminoacetamido]-3-methyl- 3-cephem-4-carboxylates (syn isomers) are readily absorbed through the digestive tract and converted in vivo to the corresponding carboxylic acids, which have outstanding antibiotic properties. These esters may be prepared by acylation of the corresponding acyloxymethyl 7- aminodesacetoxycephalosporanate, by esterification of the corresponding acid or by conversion of an undesired acyl group at the 7-position of a cephalosporin compound to the desired 7-[2-(2-aminothiazol-4-yl)-2- (hydroxy or methoxy)iminoacetyl] group.
ES499081A 1979-06-01 1981-02-03 Cephalosporin derivatives suitable for oral administration Expired ES8202559A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6829179A JPS55160782A (en) 1979-06-01 1979-06-01 Cephalosporin compound for oral administration
JP8421979A JPS568391A (en) 1979-07-03 1979-07-03 Cephalosporin compound for oral use

Publications (2)

Publication Number Publication Date
ES499081A0 ES499081A0 (en) 1982-02-01
ES8202559A1 true ES8202559A1 (en) 1982-02-01

Family

ID=26409507

Family Applications (2)

Application Number Title Priority Date Filing Date
ES492045A Granted ES492045A0 (en) 1979-06-01 1980-05-30 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF CEFALOSPORANIC ACI-DO
ES499081A Expired ES8202559A1 (en) 1979-06-01 1981-02-03 Cephalosporin derivatives suitable for oral administration

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES492045A Granted ES492045A0 (en) 1979-06-01 1980-05-30 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF CEFALOSPORANIC ACI-DO

Country Status (6)

Country Link
DE (1) DE3020625A1 (en)
ES (2) ES492045A0 (en)
FR (1) FR2457870A1 (en)
GB (1) GB2051066A (en)
IT (1) IT8067851A0 (en)
NL (1) NL8003186A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK379681A (en) * 1981-07-17 1983-01-18 Hoffmann La Roche METHOD OF PREPARING CEPHALOSPORIDE DERIVATIVES
EP0148007A3 (en) * 1983-12-26 1986-04-02 Yamanouchi Pharmaceutical Co. Ltd. Cephalosporin compounds and medicaments and their production
US4914091A (en) * 1984-04-02 1990-04-03 American Cyanamid Company Esters of cephalosporin derivitives
US4935508A (en) * 1988-08-23 1990-06-19 Bristol-Myers Company Process for cephem prodrug esters

Also Published As

Publication number Publication date
GB2051066A (en) 1981-01-14
ES8105326A1 (en) 1981-05-16
NL8003186A (en) 1980-12-03
FR2457870A1 (en) 1980-12-26
DE3020625A1 (en) 1980-12-04
ES492045A0 (en) 1981-05-16
ES499081A0 (en) 1982-02-01
IT8067851A0 (en) 1980-05-30

Similar Documents

Publication Publication Date Title
AU1741783A (en) 1-acetoxyethyl ester of (6r, 7r)-3-carbamoyloxy-methyl-7- ((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em- carboxylic acid
IE780642L (en) CEPHALOSPORIN DERIVATIVES AND RELATED ß-LACTAMS.
NO173547C (en) Analogous Procedures for the Preparation of Therapeutically Active Quinolone Carboxylic Acid Derivatives
NZ241250A (en) 7-((2-aminothiazol-4-yl)oximinoacetylamino-1-carba-1-(1-dethia)-3-cephem-4-carboxylic acid derivatives substituted in the 3-position by thiazolothio or pyridothiazolothio groups; intermediates; pharmaceutical compositions
FI923966A0 (en) 3-KEFEM-4-CARBONSYRA-1- (ISOPROPOXICARBONYLOXY) -ETHYL ESTERS DIASTEREOMERERS AND FOERFARANDE FOR DERASE FRAMSTAELLNING.
ES468895A1 (en) Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
ES8202559A1 (en) Cephalosporin derivatives suitable for oral administration
AU3929789A (en) New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as medicinal agents, pharmaceutical products and intermediates
IE41657L (en) Cephalosporin esters
EP0157000A3 (en) Ester of cephalosporin derivatives
SE432255B (en) PROCEDURE FOR PREPARING ESTER DERIVATIVES OF (6R, 7R) -3-CARBAMOYLOXIMETHYL-7 - ((Z) -2- (FUR-2-YL) -2METOXIIMINOACETAMIDO) -CEF-3-EM-4-CARBONIC ACID
EP0122584A3 (en) Crystalline form of ceftazidim
JPS54126735A (en) Bactericidal composition for medical use
NZ223334A (en) Imidazo and triazolo-thiadiazine derivatives and pharmaceutical compositions
JPS5278891A (en) Synthesis of cephalosporin antibiotics
IE790841L (en) Omega - (1,3-dithiolan-2-imino) substituted acetic acids
AU560185B2 (en) Penicillin derivatives
IL84539A (en) 7-(2-(2-aminothiazol-4-yl)-2- (alkoxyimino) acetamido)-3- ((disubstituted benzoyl) oxymethyl)-3-cephem- 4-carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
JPS568391A (en) Cephalosporin compound for oral use
IT1141286B (en) ESTERS OF DESACETOXY Cephalosporins THEIR SALTS AND PROCEDURES FOR THEIR OBTAINING
RU93058370A (en) NEW CEPHALOSPORINS WITH CONDENSED Pyridinium Methyl in the 3rd Position
SE8406171D0 (en) CHLOROCEFADROXIL MONOHYDRATE
IT8419270A0 (en) (6R,7R)-3CARBAMOYLOXYMETHYL-7-[2-(2-FURYL)2-(METHOXYIMINIO)ACETAMYDO]-CEF-3EM-4-CARBOXYLIC ACID ESTERS, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
CA968793A (en) Acyloxyalkyl ester derivatives of cephalosporin
NO167574C (en) PROCEDURE FOR THE PREPARATION OF 3-SUBSTITUTED 7- (2- (2-AMINOTIAZOL-4-YL) -2- (SYN) -ALCOXYIMINOACETAMIDO-DELTA3-CEFEM CARBOXYLIC ACID DERIVATIVES.