IL84539A - 7-(2-(2-aminothiazol-4-yl)-2- (alkoxyimino) acetamido)-3- ((disubstituted benzoyl) oxymethyl)-3-cephem- 4-carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

7-(2-(2-aminothiazol-4-yl)-2- (alkoxyimino) acetamido)-3- ((disubstituted benzoyl) oxymethyl)-3-cephem- 4-carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL84539A
IL84539A IL84539A IL8453987A IL84539A IL 84539 A IL84539 A IL 84539A IL 84539 A IL84539 A IL 84539A IL 8453987 A IL8453987 A IL 8453987A IL 84539 A IL84539 A IL 84539A
Authority
IL
Israel
Prior art keywords
aminothiazol
alkoxyimino
cephem
oxymethyl
acetamido
Prior art date
Application number
IL84539A
Other versions
IL84539A0 (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL84539A0 publication Critical patent/IL84539A0/en
Publication of IL84539A publication Critical patent/IL84539A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Derivatives corresponding to the general formula: <IMAGE> in which: - R1, R2 and R3 denote H, or R1 and R2 denote H or CH3 and R3 = COOH or else <IMAGE> form a cyclobutyl group and R3 = COOH; - A and B are different and occupy the meta and para positions of the benzene nucleus; one denotes a hydroxyl group and the other is chosen from the groups <IMAGE> and the pharmaceutically acceptable salts and esters of the said derivatives. Use in therapeutics.
IL84539A 1986-11-20 1987-11-19 7-(2-(2-aminothiazol-4-yl)-2- (alkoxyimino) acetamido)-3- ((disubstituted benzoyl) oxymethyl)-3-cephem- 4-carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them IL84539A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8616175A FR2607135B1 (en) 1986-11-20 1986-11-20 NOVEL CEPHALOSPORINS DERIVATIVES WITH IMPROVED PHARMACOKINETICS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
IL84539A0 IL84539A0 (en) 1988-04-29
IL84539A true IL84539A (en) 1992-12-01

Family

ID=9341024

Family Applications (1)

Application Number Title Priority Date Filing Date
IL84539A IL84539A (en) 1986-11-20 1987-11-19 7-(2-(2-aminothiazol-4-yl)-2- (alkoxyimino) acetamido)-3- ((disubstituted benzoyl) oxymethyl)-3-cephem- 4-carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them

Country Status (13)

Country Link
EP (1) EP0269512B1 (en)
JP (1) JPS63141985A (en)
KR (1) KR880006251A (en)
AT (1) ATE67208T1 (en)
DE (1) DE3772936D1 (en)
DK (1) DK611987A (en)
ES (1) ES2038997T3 (en)
FR (1) FR2607135B1 (en)
GR (1) GR3002769T3 (en)
IL (1) IL84539A (en)
NZ (1) NZ222593A (en)
PT (1) PT86164B (en)
ZA (1) ZA878710B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2621589B1 (en) * 1987-10-08 1990-03-02 Sanofi Sa CEPHALOSPORIN DERIVATIVES WITH IMPROVED PHARMACOKINETICS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5189157A (en) * 1987-06-16 1993-02-23 Hoffmann La Roche Inc. Antibacterial cephalosporin compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2546520B1 (en) * 1983-05-27 1985-08-30 Sanofi Sa NOVEL ANTIBIOTIC COMPOUNDS DERIVED FROM CEPHALOSPORINS
FR2570702B1 (en) * 1984-09-27 1987-01-09 Sanofi Sa CEPHALOSPORIN DERIVATIVES, PROCESSES FOR OBTAINING THEM AND THEIR APPLICATION AS ANTIBIOTICS

Also Published As

Publication number Publication date
AU597748B2 (en) 1990-06-07
NZ222593A (en) 1989-04-26
EP0269512B1 (en) 1991-09-11
DK611987D0 (en) 1987-11-20
DE3772936D1 (en) 1991-10-17
ZA878710B (en) 1988-05-20
KR880006251A (en) 1988-07-22
AU8134887A (en) 1988-05-26
FR2607135A1 (en) 1988-05-27
PT86164A (en) 1987-12-01
DK611987A (en) 1988-05-21
ATE67208T1 (en) 1991-09-15
ES2038997T3 (en) 1993-08-16
EP0269512A1 (en) 1988-06-01
GR3002769T3 (en) 1993-01-25
PT86164B (en) 1990-11-20
FR2607135B1 (en) 1989-04-28
IL84539A0 (en) 1988-04-29
JPS63141985A (en) 1988-06-14

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